Institution
University of Bordeaux
Education•Bordeaux, France•
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.
Topics: Population, Laser, Raman spectroscopy, Polymerization, Crystal structure
Papers published on a yearly basis
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TL;DR: Using sequencing and gene expression analyses, a subgroup of HCA is identified by fusion of the INHBE and GLI1 genes and activation of sonic hedgehog pathway associated with malignant transformation and bleeding, respectively.
272 citations
TL;DR: It is shown that the sexually dimorphic neurotensin neurons in the preoptic area possess oestrogen receptors and that female rats have larger number of neurons co-localizing neurotens in and oestrogens receptors.
272 citations
272 citations
TL;DR: Questions about myostatin-mediated regulation of the anabolic and catabolic signaling pathways in skeletal muscle are highlighted to highlight outstanding questions about the underlying mechanisms only partially understood.
Abstract: Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative regulator of skeletal muscle growth and is conserved in many species, from rodents to humans. Myostatin inactivation can induce skeletal muscle hypertrophy, while its overexpression or systemic administration causes muscle atrophy. As it represents a potential target for stimulating muscle growth and/or preventing muscle wasting, myostatin regulation and functions in the control of muscle mass have been extensively studied. A wealth of data strongly suggests that alterations in skeletal muscle mass are associated with dysregulation in myostatin expression. Moreover, myostatin plays a central role in integrating/mediating anabolic and catabolic responses. Myostatin negatively regulates the activity of the Akt pathway, which promotes protein synthesis, and increases the activity of the ubiquitin-proteasome system to induce atrophy. Several new studies have brought new information on how myostatin may affect both ribosomal biogenesis and translation efficiency of specific mRNA subclasses. In addition, although myostatin has been identified as a modulator of the major catabolic pathways, including the ubiquitin-proteasome and the autophagy-lysosome systems, the underlying mechanisms are only partially understood. The goal of this review is to highlight outstanding questions about myostatin-mediated regulation of the anabolic and catabolic signaling pathways in skeletal muscle. Particular emphasis has been placed on (1) the cross-regulation between myostatin, the growth-promoting pathways and the proteolytic systems; (2) how myostatin inhibition leads to muscle hypertrophy; and (3) the regulation of translation by myostatin.
272 citations
TL;DR: The LiNiO2LiCoO2 system exhibits a complete solid solution as discussed by the authors and the highest specific energy (close to 500 W h/kg) is obtained in the LixNi0.7Co0.3O 2 system.
272 citations
Authors
Showing all 28995 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Nicholas G. Martin | 192 | 1770 | 161952 |
| George F. Koob | 171 | 935 | 112521 |
| Daniel J. Jacob | 162 | 656 | 76530 |
| Arthur W. Toga | 159 | 1184 | 109343 |
| James M. Tour | 143 | 859 | 91364 |
| Floyd E. Bloom | 139 | 616 | 72641 |
| Herbert Y. Meltzer | 137 | 1148 | 81371 |
| Jean-Marie Tarascon | 136 | 853 | 137673 |
| Stanley Nattel | 132 | 778 | 65700 |
| Michel Haïssaguerre | 117 | 757 | 62284 |
| Liquan Chen | 111 | 689 | 44229 |
| Marion Leboyer | 110 | 773 | 50767 |
| Jean-François Dartigues | 106 | 631 | 46682 |
| Alexa S. Beiser | 106 | 366 | 47457 |
| Robert Dantzer | 105 | 497 | 46554 |