Institution
University of Bordeaux
Education•Bordeaux, France•
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.
Topics: Population, Laser, Raman spectroscopy, Polymerization, Crystal structure
Papers published on a yearly basis
Papers
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TL;DR: This work investigated a staged anatomical approach using radiofrequency catheter ablation lines to prevent paroxysmal AF, the most common arrhythmia in women.
Abstract: Ablation of Paroxysmal Atrial Fibrillation. Introduction: (AF), trial fibrillation (AF), the most common arrhythmia, is due to multiple simultaneous wavelets of reentry in the atria. The only available curative treatment is surreal, using atriotomies to compartmentalize the atria. Therefore, we investigated a staged anatomical approach using radiofrequency catheter ablation lines to prevent paroxysmal AF.
Methods and Results: Forty-live patients with frequent symptomatic drug-refractory episodes of paroxysmal AF were studied. Progressively complex linear lesions were created by sequential applications of radiofrequency current in the right atrium and then in the left atrium if required. The outcome of the procedure was considered a success when the episodes of AF were either eliminated or recurred at a rate of no more than one episode (lasting < 6 hours) in 3 months. Patients who had no more than one episode per month were considered “improved.” Right atrial ablation organized local electrical activity and led to stable sinus rhythm during the procedure in 18 (40%) of the 45 patients. However, sustained AF remained inducible in 40 of 45 patients, and the lesions failed to produce evidence of a significant linear conduction block/delay in all but four patients. There were no significant complications except for two transient sinus node dysfunctions. The procedure duration and fluoroscopic time were 248 ± 79 and 53 ± 11 min, respectively. Additional sessions were required in 19 patients to treat sustained right atrial flutter or arrhythmias linked to ectopic right or left atrial foci. During a mean follow-up of 11 ± 4 months, right atrial ablation was successful in 15 (33%) patients, ft without medication and 9 with a previously ineffective drug. Nine (20%) additional patients were improved. Ten patients with an unsuccessful outcome then underwent linear ablation in the left atrium. The procedure duration and fluoroscopy time were 292 ± 94 and 66 ± 24 min. A hemopericardium occurred in one patient. Two patients required reablation to treat ectopic atrial foci. Left atrial ablation terminated AF during the procedure in 8 patients, and sustained AF could not he induced in 5. Subsequent success was achieved in A (60%) patients, including 4 without medication, and 1 additional patient was improved.
Conclusions: Successful radiofrequency catheter ablation of drug-refractory daily paroxysmal AF is feasible using linear atrial lesions complemented by focal ablation targeted at arrhythmogenic foci. Ablation only in the right atrium is a safe technique providing limited success, whereas linear lesions in the left atrium significantly increase the incidence of stable restoration of sinus rhythm, the inability to induce sustained AF, and the final success rate. The described technique is promising hut must he considered preliminary because significant Improvements are required to optimize lesion characteristics and shorten total procedure duration.
653 citations
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Utrecht University1, Yale University2, Rice University3, Purdue University4, Alfred Wegener Institute for Polar and Marine Research5, Stockholm University6, University of Rhode Island7, Brown University8, United States Geological Survey9, University of Bordeaux10, Aix-Marseille University11, Centre national de la recherche scientifique12, Yamagata University13, University College London14, Norwegian Polar Institute15, Boston University16, British Geological Survey17, University of Michigan18, Kyushu University19, University of Southampton20, University of Aberdeen21, University of Padua22, Japan Agency for Marine-Earth Science and Technology23, James Madison University24, University of Tsukuba25, Tohoku University26, National Institute of Advanced Industrial Science and Technology27, Hokkaido University28
TL;DR: It is shown that sea surface temperatures near the North Pole increased from ∼18 °C to over 23°C during this event, which suggests that higher-than-modern greenhouse gas concentrations must have operated in conjunction with other feedback mechanisms—perhaps polar stratospheric clouds or hurricane-induced ocean mixing—to amplify early Palaeogene polar temperatures.
Abstract: The Palaeocene/Eocene thermal maximum, ~55 million years ago, was a brief period of widespread, extreme climatic warming1, 2, 3, that was associated with massive atmospheric greenhouse gas input4. Although aspects of the resulting environmental changes are well documented at low latitudes, no data were available to quantify simultaneous changes in the Arctic region. Here we identify the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence obtained during the Arctic Coring Expedition5. We show that sea surface temperatures near the North Pole increased from ~18 °C to over 23 °C during this event. Such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming. At the same time, sea level rose while anoxic and euxinic conditions developed in the ocean's bottom waters and photic zone, respectively. Increasing temperature and sea level match expectations based on palaeoclimate model simulations6, but the absolute polar temperatures that we derive before, during and after the event are more than 10 °C warmer than those model-predicted. This suggests that higher-than-modern greenhouse gas concentrations must have operated in conjunction with other feedback mechanisms—perhaps polar stratospheric clouds7 or hurricane-induced ocean mixing8—to amplify early Palaeogene polar temperatures.
652 citations
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TL;DR: The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy, with the largest apparent energy release yet measured.
Abstract: Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gamma-ray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. The known distance of the burst enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.
651 citations
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University of Amsterdam1, University of Bordeaux2, Semmelweis University3, French Institute of Health and Medical Research4, University of Oxford5, Karolinska Institutet6, Imperial College London7, University of Bristol8, Medical University of Warsaw9, Ghent University10, La Trobe University11, University of North Carolina at Chapel Hill12, University of Tartu13, Icahn School of Medicine at Mount Sinai14, University of Helsinki15
TL;DR: This review provides an expert-based update of recent advances in the methods to study EVs and summarizes currently accepted considerations and recommendations from sample collection to isolation, detection, and characterization of EVs.
Abstract: Owing to the relationship between extracellular vesicles (EVs) and physiological and pathological conditions, the interest in EVs is exponentially growing. EVs hold high hopes for novel diagnostic and translational discoveries. This review provides an expert-based update of recent advances in the methods to study EVs and summarizes currently accepted considerations and recommendations from sample collection to isolation, detection, and characterization of EVs. Common misconceptions and methodological pitfalls are highlighted. Although EVs are found in all body fluids, in this review, we will focus on EVs from human blood, not only our most complex but also the most interesting body fluid for cardiovascular research.
651 citations
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TL;DR: The Fermi Large Area Telescope measured separate cosmic-ray electron and positron spectra to distinguish the two species by exploiting Earth's shadow, and it is confirmed that the fraction rises with energy in the 20-100 GeV range.
Abstract: We measured separate cosmic-ray electron and positron spectra with the Fermi Large Area Telescope. Because the instrument does not have an onboard magnet, we distinguish the two species by exploiting the Earth's shadow, which is offset in opposite directions for opposite charges due to the Earth's magnetic field. We estimate and subtract the cosmic-ray proton background using two different methods that produce consistent results. We report the electron-only spectrum, the positron-only spectrum, and the positron fraction between 20 GeV and 200 GeV. We confirm that the fraction rises with energy in the 20--100 GeV range and determine for the first time that it continues to rise between 100 and 200 GeV.
651 citations
Authors
Showing all 28995 results
Name | H-index | Papers | Citations |
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Nicholas G. Martin | 192 | 1770 | 161952 |
George F. Koob | 171 | 935 | 112521 |
Daniel J. Jacob | 162 | 656 | 76530 |
Arthur W. Toga | 159 | 1184 | 109343 |
James M. Tour | 143 | 859 | 91364 |
Floyd E. Bloom | 139 | 616 | 72641 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
Stanley Nattel | 132 | 778 | 65700 |
Michel Haïssaguerre | 117 | 757 | 62284 |
Liquan Chen | 111 | 689 | 44229 |
Marion Leboyer | 110 | 773 | 50767 |
Jean-François Dartigues | 106 | 631 | 46682 |
Alexa S. Beiser | 106 | 366 | 47457 |
Robert Dantzer | 105 | 497 | 46554 |