University of Bordeaux

About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.

Sums involving the values at negative integers of L-functions of quadratic characters

Abstract: For each integer r > 1 we will define an arithmetic function H(r, N) which for r = 1 is the class number of (not necessarily primitive) quadratic forms of discriminant N and for r > 1 is essentially the value of ~K(r) where K = ~ ( ] / ~ ) . For r > 2 the function ~N>_0 H(r, N)e 2~i~ is a modular form of weight r + 1/2 on Fo(4 ). This implies numerous identities involving H(r, N). The analogous formulas for r = 1 (which do not follow from the methods of this paper) are classical "class number relations" of Kronecker, Hurwitz and others, as well as certain generalizations coming from the Selberg-Eichler trace formula and from recent work of Hirzebruch-Zagier. One of the tools used is of independent interest: given two modular f o r m s f a n d 9, there are certain bilinear expressions in the derivatives o f f and 9 which are again modular forms.

The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome

Abstract: Purpose This study was designed to identify factors associated with death by 6 months post-intensive care unit (ICU) discharge and to develop a practical mortality risk score for extracorporeal membrane oxygenation (ECMO)-treated acute respiratory distress syndrome (ARDS) patients. We also assessed long-term survivors’ health-related quality of life (HRQL), respiratory symptoms, and anxiety, depression and post-traumatic stress disorder (PTSD) frequencies.

Synchroneity between marine and terrestrial responses to millennial scale climatic variability during the last glacial period in the Mediterranean region

Abstract: Land–sea climatic proxies have been obtained from the Last Glacial section of IMAGES core MD95-2043 (western Mediterranean Sea). Vegetation and alkenone derived SST curves indicate rapid (∼150 years) and synchronous terrestrial and marine climatic changes, paralleling the Dansgaard–Oeschger (D–O) climatic variability over Greenland. This frequency of climate change can be related to shifts between the two modes of operation of the North Atlantic Oscillation (NAO). Transfer functions applied to the pollen data indicate that there was an amplification of the climatic signal during Heinrich events (HEs) in comparison with other D–O stadials. The development and persistence of both Scandinavian and Atlantic Mobile Polar Highs over southwestern Europe may explain the extreme cooling (∼10 °C) and dryness (400 mm) during Heinrich events 5 and 4 in the Mediterranean region. Comparison of the results of core MD95-2043 with similar climatic data from IMAGES core MD95-2042, located off Portugal, indicates that thermal and precipitation gradients occurred between the Mediterranean and the Atlantic sides of Iberia within HEs. HEs 4 and 5 are associated with more humid conditions in the Atlantic (by 200 mm) than in the Mediterranean site, as is the case at the present time. This comparison also illustrates the different behaviour of these areas during the D–O stadials. In contrast with the Mediterranean site, the Atlantic site shows similar precipitation and temperature drops for all the D–O stadials, including those related to the HEs. Here we propose the operation of different Mobile Polar Highs (MPH) as the driving mechanism for this difference in behaviour between the Atlantic and Mediterranean sides of Iberia. HEs are related to a stronger influence of the Scandinavian MPH, forcing a severe aridification and cooling of the full Iberian Peninsula. The Atlantic MPH may have been dominant during the other stadials, which would preferentially affect Southwestern Iberia.

Multicenter Double-Blind, Randomized, Placebo-Controlled Trial of Levetiracetam as Add-On Therapy in Patients with Refractory Partial Seizures

Abstract: Summary: Purpose: To evaluate the efficacy and tolerability of levetiracetam (LEV, Keppra) as add-on therapy in patients with refractory partial seizures. Methods: In this European multicenter, double-blind, randomized, placebo-controlled trial, LEV (500 or 1,000 mg twice daily) was compared with placebo as add-on therapy in 324 patients with uncontrolled simple or complex partial seizures, or both, with or without secondary generalization. After enrollment, three parallel groups were assessed during a baseline period of 8 or 12 weeks, followed by a 4-week titration interval and a 12-week evaluation period. Results: LEV significantly decreased partial seizure frequency compared with placebo. A reduction in seizure frequency of 50% occurred in 22.8% of patients in the 1,000-mg group and 31.6% of patients in the 2,000-mg group, compared with 10.4% of patients in the placebo group. Administration of LEV did not affect plasma concentrations of concomitant an-tiepileptic drugs or alter vital signs or laboratory parameters. No significant difference in the incidence of adverse events was observed between treatment groups (70.8% for the 1,000-mg group and 75.5% for the 2,000-mg group), or between the LEV and placebo groups (73.2% for placebo group). The most commonly reported adverse effects in the LEV group were asthenia, headache, and somnolence. Conclusions: The antiepileptic efficacy and tolerability of LEV (1,000 mg/d and 2,000 mg/d, administered in two divided doses) as add-on therapy was established in patients with refractory partial seizures in this clinical study.