Institution
University of Bordeaux
Education•Bordeaux, France•
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.
Topics: Population, Laser, Context (language use), Raman spectroscopy, Medicine
Papers published on a yearly basis
Papers
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TL;DR: Insect and fungus feeding behaviour, affected tree part, and water stress severity are proposed as three important predictors of forest damage in drought conditions.
Abstract: In the context of climate change, the effects of prolonged or more severe droughts on pest and pathogen damage are a major concern for forest ecosystems. To date, there is great uncertainty about the direction, magnitude and sources of variation in responses to drought by insects and fungi. We report the outcomes of a meta-analysis of 100 pairwise comparisons of insect pest or pathogen damage to water-stressed and control trees from 40 publications. The type of feeding substrate for insects and fungi and the water stress severity emerged as the main factors influencing the level of damage in water-stressed trees. Overall, primary damaging agents living in wood caused significantly lower damage to the water-stressed trees compared with the control, whereas primary pests and pathogens living on foliage caused more damage to water-stressed trees, in all cases irrespective of stress severity. In contrast, damage by secondary agents increased with stress severity, which was best estimated by the ratio between the predawn leaf water potential in stressed trees and the xylem pressure inducing 50% loss in hydraulic conductance due to cavitation, a species-specific index of drought tolerance. Insect and fungus feeding behaviour, affected tree part, and water stress severity are therefore proposed as three important predictors of forest damage in drought conditions.
384 citations
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University of Milan1, University of Bordeaux2, French Institute of Health and Medical Research3, University of Utah4, University of Rome Tor Vergata5, University of Catania6, Charité7, University of Naples Federico II8, University of Zaragoza9, McGill University10, Obafemi Awolowo University11, Catholic University of Korea12
TL;DR: In this study, CML-related deaths were uncommon in CML patients who were in CCyR 2 years after starting imatinib, and survival was not statistically significantly different from that of the general population.
Abstract: BACKGROUND Imatinib slows development of chronic myeloid leukemia (CML). However, available information on morbidity and mortality is largely based on sponsored trials, whereas independent long-term field studies are lacking. PATIENTS AND METHODS Consecutive CML patients who started imatinib treatment before 2005 and who were in complete cytogenetic remission (CCyR) after 2 years (± 3 months) were eligible for enrollment in the independent multicenter Imatinib Long-Term (Side) Effects (ILTE) study. Incidence of the first serious and nonserious adverse events and loss of CCyR were estimated according to the Kaplan-Meier method and compared with the standard log-rank test. Attainment of negative Philadelphia chromosome hematopoiesis was assessed with cytogenetics and quantitative polymerase chain reaction. Cumulative incidence of death related or unrelated to CML progression was estimated, accounting for competing risks, according to the Kalbleisch-Prentice method. Standardized incidence ratios were calculated based on population rates specific for sex and age classes. Confidence intervals were calculated by the exact method based on the χ(2) distribution. All statistical tests were two-sided. RESULTS A total of 832 patients who were treated for a median of 5.8 years were enrolled. There were 139 recorded serious adverse events, of which 19.4% were imatinib-related. A total of 830 nonserious adverse events were observed in 53% of patients; 560 (68%) were imatinib-related. The most frequent were muscle cramps, asthenia, edema, skin fragility, diarrhea, tendon, or ligament lesions. Nineteen patients (2.3%) discontinued imatinib because of drug-related toxic effects. Forty-five patients lost CCyR, at a rate of 1.4 per 100 person-years. Durable (>1 year) negative Philadelphia chromosome hematopoiesis was attained by 179 patients. Twenty deaths were observed, with a 4.8% mortality incidence rate (standardized incidence ratio = 0.7; 95% confidence interval = 0.40 to 1.10, P = .08), with only six (30%) associated with CML progression. CONCLUSIONS In this study, CML-related deaths were uncommon in CML patients who were in CCyR 2 years after starting imatinib, and survival was not statistically significantly different from that of the general population.
384 citations
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University of Rouen1, University of Paris2, University of Toulouse3, Aix-Marseille University4, Sorbonne5, university of lille6, University of Nantes7, University of Rennes8, University of Angers9, University of Clermont-Ferrand10, University of Limoges11, Claude Bernard University Lyon 112, François Rabelais University13, University of Bordeaux14, University of Montpellier15
TL;DR: Data from this trial suggest that first-line use of rituximab plus short-termprednisone for patients with pemphigus is more effective than using prednisone alone, with fewer adverse events.
384 citations
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TL;DR: It is observed that composite nanotube fibers that exhibit this particular feature can generate a stress upon shape recovery up to two orders of magnitude greater than that generated by conventional polymers.
Abstract: Shape-memory polymers can revert to their original shape when they are reheated. The stress generated by shape recovery is a growing function of the energy absorbed during deformation at a high temperature; thus, high energy to failure is a necessary condition for strong shape-memory materials. We report on the properties of composite nanotube fibers that exhibit this particular feature. We observed that these composites can generate a stress upon shape recovery up to two orders of magnitude greater than that generated by conventional polymers. In addition, the nanoparticles induce a broadening of the glass transition and a temperature memory with a peak of recovery stress at the temperature of their initial deformation.
382 citations
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TL;DR: It is demonstrated that CMV envelope glycoprotein B is a viral ligand for DC-SIGN and DC- SIGNR and this results provide new insights into the molecular interactions contributing to cell infection by CMV and extendDC-SIGN implication in virus propagation.
381 citations
Authors
Showing all 28995 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas G. Martin | 192 | 1770 | 161952 |
George F. Koob | 171 | 935 | 112521 |
Daniel J. Jacob | 162 | 656 | 76530 |
Arthur W. Toga | 159 | 1184 | 109343 |
James M. Tour | 143 | 859 | 91364 |
Floyd E. Bloom | 139 | 616 | 72641 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
Stanley Nattel | 132 | 778 | 65700 |
Michel Haïssaguerre | 117 | 757 | 62284 |
Liquan Chen | 111 | 689 | 44229 |
Marion Leboyer | 110 | 773 | 50767 |
Jean-François Dartigues | 106 | 631 | 46682 |
Alexa S. Beiser | 106 | 366 | 47457 |
Robert Dantzer | 105 | 497 | 46554 |