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Institution

University of Bremen

EducationBremen, Germany
About: University of Bremen is a education organization based out in Bremen, Germany. It is known for research contribution in the topics: Population & Glacial period. The organization has 14563 authors who have published 37279 publications receiving 970381 citations. The organization is also known as: Universität Bremen.


Papers
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Journal ArticleDOI
01 May 2009-Allergy
TL;DR: This first article in a three‐part series describes the GRADE framework in relation to grading the quality of evidence about interventions based on examples from the field of allergy and asthma.
Abstract: The GRADE (Grades of Recommendation, Assessment, Development, and Evaluation) approach provides guidance to grading the quality of underlying evidence and the strength of recommendations in health care. The GRADE system's conceptual underpinnings allow for a detailed stepwise process that defines what role the quality of the available evidence plays in the development of health care recommendations. The merit of GRADE is not that it eliminates judgments or disagreements about evidence and recommendations, but rather that it makes them transparent. This first article in a three-part series describes the GRADE framework in relation to grading the quality of evidence about interventions based on examples from the field of allergy and asthma. In the GRADE system, the quality of evidence reflects the extent to which a guideline panel's confidence in an estimate of the effect is adequate to support a particular recommendation. The system classifies quality of evidence as high, moderate, low, or very low according to factors that include the study methodology, consistency and precision of the results, and directness of the evidence.

610 citations

Journal ArticleDOI
TL;DR: It is demonstrated that the changes in f1 and f2 occur simultaneously to those in the extracellular and intracellular space fractions during: (i) cell swelling after total circulatory arrest, and (ii) the recovery from N‐methyl‐D‐aspartate induced excitotoxic brain edema evoked by MK‐801, as measured by changes in the electrical impedance.
Abstract: Diffusion-weighted single voxel experiments conducted at b-values up to 1 x 10(4) smm-2 yielded biexponential signal attenuation curves for both normal and ischemic brain. The relative fractions of the rapidly and slowly decaying components (f1, f2) are f1 = 0.80 +/- 0.02, f2 = 0.17 +/- 0.02 in healthy adult rat brain and f1 = 0.90 +/- 0.02, f2 = 0.11 +/- 0.01 in normal neonatal rat brain, whereas the corresponding values for the postmortem situation are f1 = 0.69 +/- 0.02, f2 = 0.33 +/- 0.02. It is demonstrated that the changes in f1 and f2 occur simultaneously to those in the extracellular and intracellular space fractions (fex, f(in)) during: (i) cell swelling after total circulatory arrest, and (ii) the recovery from N-methyl-D-aspartate induced excitotoxic brain edema evoked by MK-801, as measured by changes in the electrical impedance. Possible reasons for the discrepancy between the estimated magnitude components and the physiological values are presented and evaluated. Implications of the biexponential signal attenuation curves for diffusion-weighted imaging experiments are discussed.

605 citations

Journal ArticleDOI
TL;DR: In this article, weathering records from the South China Sea, Bay of Bengal and Arabian Sea were used to reconstruct the earliest Neogene climate of the Himalayan orogen and showed a correlation between the rate of Himalayan exhumation and monsoon intensity.
Abstract: Although most data suggest that the India–Eurasia continental collision began ∼45–55 Myr ago, the architecture of the Himalayan–Tibetan orogen is dominated by deformational structures developed in the Neogene period (<23 Myr ago). The stratigraphic record and thermochronometric data indicate that erosion of the Himalaya intensified as this constructional phase began and reached a peak around 15 Myr ago. It remained high until ∼10.5 Myr ago and subsequently slowed gradually to ∼3.5 Myr ago, but then began to increase once again in the Late Pliocene and Pleistocene epochs. Here we present weathering records from the South China Sea, Bay of Bengal and Arabian Sea that permit Asian monsoon climate to be reconstructed back to the earliest Neogene. These indicate a correlation between the rate of Himalayan exhumation—as inferred from published thermochronometric data—and monsoon intensity over the past 23 Myr. We interpret this correlation as indicating dynamic coupling between Neogene climate and both erosion and deformation in the Himalaya. Although the India–Eurasia collision initiated ∼50 Myr ago, major deformation and exhumation of the Himalaya did not begin until the early Neogene (∼23 Myr ago). This coincides with the increased intensity of the Asian monsoons, as indicated by weathering records from the South China Sea, Bay of Bengal and Arabian Sea, and hints at a dynamic coupling between climate and both erosion and deformation in the Himalaya.

603 citations

Journal ArticleDOI
TL;DR: The Constrained Application Protocol (CoAP) is a transfer protocol for constrained nodes and networks, such as those that will form the Internet of Things, which uses the REST architectural style.
Abstract: The Constrained Application Protocol (CoAP) is a transfer protocol for constrained nodes and networks, such as those that will form the Internet of Things. Much like its older and heavier cousin HTTP, CoAP uses the REST architectural style. Based on UDP and unencumbered by historical baggage, however, CoAP aims to achieve its modest goals with considerably less complexity.

603 citations

Journal ArticleDOI
TL;DR: It is found that macaques do have discrete face-selective patches, similar in relative size and number to face patches in humans, and these results suggest that humans and macaques share a similar brain architecture for visual object processing.
Abstract: How are different object categories organized by the visual system? Current evidence indicates that monkeys and humans process object categories in fundamentally different ways. Functional magnetic resonance imaging (fMRI) studies suggest that humans have a ventral temporal face area, but such evidence is lacking in macaques. Instead, face-responsive neurons in macaques seem to be scattered throughout temporal cortex, with some relative concentration in the superior temporal sulcus (STS). Here, using fMRI in alert fixating macaque monkeys and humans, we found that macaques do have discrete face-selective patches, similar in relative size and number to face patches in humans. The face patches were embedded within a large swath of object-selective cortex extending from V4 to rostral TE. This large region responded better to pictures of intact objects compared to scrambled objects, with different object categories eliciting different patterns of activity, as in the human. Overall, our results suggest that humans and macaques share a similar brain architecture for visual object processing.

601 citations


Authors

Showing all 14961 results

NameH-indexPapersCitations
Roger Y. Tsien163441138267
Klaus-Robert Müller12976479391
Ron Kikinis12668463398
Ulrich S. Schubert122222985604
Andreas Richter11076948262
Michael Böhm10875566103
Juan Bisquert10745046267
John P. Sumpter10126646184
Jos Lelieveld10057037657
Michael Schulz10075950719
Peter Singer9470237128
Charles R. Tyler9232531724
John P. Burrows9081536169
Hans-Peter Kriegel8944473932
Harald Haas8575034927
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023343
2022709
20212,106
20202,309
20192,191
20181,965