Institution
University of Bremen
Education•Bremen, Germany•
About: University of Bremen is a education organization based out in Bremen, Germany. It is known for research contribution in the topics: Population & Glacial period. The organization has 14563 authors who have published 37279 publications receiving 970381 citations. The organization is also known as: Universität Bremen.
Topics: Population, Glacial period, SCIAMACHY, Sea ice, Holocene
Papers published on a yearly basis
Papers
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TL;DR: MST1 is identified as a proapoptotic kinase and key mediator of apoptotic signaling and beta cell dysfunction and suggested that it may serve as target for the development of new therapies for diabetes.
Abstract: Apoptotic cell death is a hallmark of the loss of insulin-producing beta cells in all forms of diabetes mellitus. Current treatments fail to halt the decline in functional beta cell mass, and strategies to prevent beta cell apoptosis and dysfunction are urgently needed. Here, we identified mammalian sterile 20–like kinase-1 (MST1) as a critical regulator of apoptotic beta cell death and function. Under diabetogenic conditions, MST1 was strongly activated in beta cells in human and mouse islets and specifically induced the mitochondrial-dependent pathway of apoptosis through upregulation of the BCL-2 homology-3 (BH3)-only protein BIM. MST1 directly phosphorylated the beta cell transcription factor PDX1 at T11, resulting in the latter’s ubiquitination and degradation and thus in impaired insulin secretion. MST1 deficiency completely restored normoglycemia, beta cell function and survival in vitro and in vivo. We show MST1 as a proapoptotic kinase and key mediator of apoptotic signaling and beta cell dysfunction and suggest that it may serve as target for the development of new therapies for diabetes.
180 citations
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TL;DR: The history of the Late Weichselian northwestern Barents Shelf, including western Svalbard, has been investigated by provenance/sedimentologist studies of five cores.
180 citations
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TL;DR: In this paper, a rotating disk technique was used to investigate the effect of the DBL on the dissolution rates of CaCO 3, which allowed an exact adjustment of the thickness of the diffusion boundary layer by controlling the rotation speed of a circular sample of Ca CO 3.
180 citations
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TL;DR: Palaeoclimatic evidence of monsoon rainfall dynamics across different regions and timescales could help to understand and predict the sensitivity and response of monsoons to various forcing mechanisms.
Abstract: Monsoons are the dominant seasonal mode of climate variability in the tropics and are critically important conveyors of atmospheric moisture and energy at a global scale. Predicting monsoons, which have profound impacts on regions that are collectively home to more than 70 per cent of Earth's population, is a challenge that is difficult to overcome by relying on instrumental data from only the past few decades. Palaeoclimatic evidence of monsoon rainfall dynamics across different regions and timescales could help us to understand and predict the sensitivity and response of monsoons to various forcing mechanisms. This evidence suggests that monsoon systems exhibit substantial regional character.
180 citations
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California Institute of Technology1, Goddard Space Flight Center2, University of Bristol3, Utrecht University4, Université libre de Bruxelles5, National Center for Atmospheric Research6, University of Tokyo7, Université Paris-Saclay8, Potsdam Institute for Climate Impact Research9, Los Alamos National Laboratory10, Australian Antarctic Division11, University of Lapland12, Victoria University of Wellington13, University of Reading14, Met Office15, Hokkaido University16, University of Tromsø17, Norwegian Polar Institute18, University of Bremen19, Alfred Wegener Institute for Polar and Marine Research20, Vrije Universiteit Brussel21, University of Grenoble22, GNS Science23, University of California, Irvine24, University of Leeds25, University of California, San Diego26, Pennsylvania State University27, University of Potsdam28, University of Tasmania29, CSC – IT Center for Science30
TL;DR: In this paper, the authors present results from ice flow model simulations from 13 international groups focusing on the evolution of the Antarctic ice sheet during the period 2015-2100 as part of the Ice Sheet Model Comparison for CMIP6 (ISMIP6).
Abstract: . Ice flow models of the Antarctic ice sheet are commonly used to simulate its future evolution in
response to different climate scenarios and assess the mass loss that would contribute to
future sea level rise. However, there is currently no consensus on estimates of the future mass
balance of the ice sheet, primarily because of differences in the representation of physical
processes, forcings employed and initial states of ice sheet models. This study presents
results from ice flow model simulations from 13 international groups focusing on the evolution
of the Antarctic ice sheet during the period 2015–2100 as part of the Ice Sheet Model
Intercomparison for CMIP6 (ISMIP6). They are forced with outputs from a subset of models from the
Coupled Model Intercomparison Project Phase 5 (CMIP5), representative of the spread in climate
model results. Simulations of the Antarctic ice sheet contribution to sea level rise in response
to increased warming during this period varies between −7.8 and 30.0 cm of sea level equivalent
(SLE) under Representative Concentration
Pathway (RCP) 8.5 scenario forcing. These numbers are relative to a control experiment with
constant climate conditions and should therefore be added to the mass loss contribution under
climate conditions similar to present-day conditions over the same period. The simulated evolution of the
West Antarctic ice sheet varies widely among models, with an overall mass loss, up to 18.0 cm SLE, in response to changes in oceanic conditions. East Antarctica mass change varies between −6.1 and
8.3 cm SLE in the simulations, with a significant increase in surface mass balance outweighing
the increased ice discharge under most RCP 8.5 scenario forcings. The inclusion of ice shelf
collapse, here assumed to be caused by large amounts of liquid water ponding at the surface of
ice shelves, yields an additional simulated mass loss of 28 mm compared to simulations without ice
shelf collapse. The largest sources of uncertainty come from the climate forcing, the ocean-induced melt rates, the
calibration of these melt rates based on oceanic conditions taken outside of ice shelf cavities
and the ice sheet dynamic response to these oceanic changes. Results under RCP 2.6 scenario based
on two CMIP5 climate models show an additional mass loss of 0 and 3 cm of SLE on average compared to
simulations done under present-day conditions for the two CMIP5 forcings used and display
limited mass gain in East Antarctica.
180 citations
Authors
Showing all 14961 results
Name | H-index | Papers | Citations |
---|---|---|---|
Roger Y. Tsien | 163 | 441 | 138267 |
Klaus-Robert Müller | 129 | 764 | 79391 |
Ron Kikinis | 126 | 684 | 63398 |
Ulrich S. Schubert | 122 | 2229 | 85604 |
Andreas Richter | 110 | 769 | 48262 |
Michael Böhm | 108 | 755 | 66103 |
Juan Bisquert | 107 | 450 | 46267 |
John P. Sumpter | 101 | 266 | 46184 |
Jos Lelieveld | 100 | 570 | 37657 |
Michael Schulz | 100 | 759 | 50719 |
Peter Singer | 94 | 702 | 37128 |
Charles R. Tyler | 92 | 325 | 31724 |
John P. Burrows | 90 | 815 | 36169 |
Hans-Peter Kriegel | 89 | 444 | 73932 |
Harald Haas | 85 | 750 | 34927 |