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Institution

University of Bremen

EducationBremen, Germany
About: University of Bremen is a education organization based out in Bremen, Germany. It is known for research contribution in the topics: Population & Glacial period. The organization has 14563 authors who have published 37279 publications receiving 970381 citations. The organization is also known as: Universität Bremen.


Papers
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Proceedings ArticleDOI
23 Oct 2006
TL;DR: This paper describes how to make use of suffix trees to find clones in abstract syntax trees and empirically compares the new technique to other techniques using the Bellon benchmark for clone detectors.
Abstract: Reusing software through copying and pasting is a continuous plague in software development despite the fact that it creates serious maintenance problems. Various techniques have been proposed to find duplicated redundant code (also known as software clones). A recent study has compared these techniques and shown that token-based clone detection based on suffix trees is extremely fast but yields clone candidates that are often no syntactic units. Current techniques based on abstract syntax trees--on the other hand--find syntactic clones but are considerably less efficient. This paper describes how we can make use of suffix trees to find clones in abstract syntax trees. This new approach is able to find syntactic clones in linear time and space. The paper reports the results of several large case studies in which we empirically compare the new technique to other techniques using the Bellon benchmark for clone detectors.

346 citations

Journal ArticleDOI
TL;DR: The stable isotope composition of planktonic foraminifera correlates with evidence for pulses of terrigenous sediment in a sediment core from the upper continental slope off northeastern Brazil as discussed by the authors.

345 citations

Journal ArticleDOI
TL;DR: The results of this survey suggest that the impacts of nitrogen deposition can be observed over a large geographical range, suggesting that to protect the most sensitive grasslands resources should be focussed where deposition is currently low.

344 citations

Journal ArticleDOI
TL;DR: In this article, the authors determined concentrations and isotopic compositions of inorganic nitrogen (IN), organic nitrogen (ON), total nitrogen (TN), and total organic carbon (TOC) on one short core recovered from sediments of the eastern subtropical Atlantic, between the Canary Islands and the Moroccan coast.

342 citations

Journal ArticleDOI
TL;DR: Fumarates suppress Th1 responses by blocking IL-12 and IL-23 production by dendritic cells via distinct pathways through distinct pathways.
Abstract: Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th) cell differentiation. However, both diseases show opposing responses to most established therapies. First, we show in humans that fumarate treatment induces IL-4–producing Th2 cells in vivo and generates type II dendritic cells (DCs) that produce IL-10 instead of IL-12 and IL-23. In mice, fumarates also generate type II DCs that induce IL-4–producing Th2 cells in vitro and in vivo and protect mice from experimental autoimmune encephalomyelitis. Type II DCs result from fumarate-induced glutathione (GSH) depletion, followed by increased hemoxygenase-1 (HO-1) expression and impaired STAT1 phosphorylation. Induced HO-1 is cleaved, whereupon the N-terminal fragment of HO-1 translocates into the nucleus and interacts with AP-1 and NF-κB sites of the IL-23p19 promoter. This interaction prevents IL-23p19 transcription without affecting IL-12p35, whereas STAT1 inactivation prevents IL-12p35 transcription without affecting IL-23p19. As a consequence, GSH depletion by small molecules such as fumarates induces type II DCs in mice and in humans that ameliorate inflammatory autoimmune diseases. This therapeutic approach improves Th1- and Th17-mediated autoimmune diseases such as psoriasis and MS by interfering with IL-12 and IL-23 production.

342 citations


Authors

Showing all 14961 results

NameH-indexPapersCitations
Roger Y. Tsien163441138267
Klaus-Robert Müller12976479391
Ron Kikinis12668463398
Ulrich S. Schubert122222985604
Andreas Richter11076948262
Michael Böhm10875566103
Juan Bisquert10745046267
John P. Sumpter10126646184
Jos Lelieveld10057037657
Michael Schulz10075950719
Peter Singer9470237128
Charles R. Tyler9232531724
John P. Burrows9081536169
Hans-Peter Kriegel8944473932
Harald Haas8575034927
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023343
2022709
20212,106
20202,309
20192,191
20181,965