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Institution

University of Bremen

EducationBremen, Germany
About: University of Bremen is a education organization based out in Bremen, Germany. It is known for research contribution in the topics: Population & Glacial period. The organization has 14563 authors who have published 37279 publications receiving 970381 citations. The organization is also known as: Universität Bremen.


Papers
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Journal ArticleDOI
TL;DR: It is concluded, that concentration addition can be useful for hazard assessment procedures of mixtures of similarly acting compounds, and that even mixture components that are present only at their individual no observed effect concentrations (NOECs) contribute to the overall toxicity of the mixture.

282 citations

Journal ArticleDOI
TL;DR: In this paper, the nitrogen isotopic composition of the Southern Ocean was analyzed and it was shown that the isotopic invariance of deep ocean nitrate stems fundamentally from the completeness of nitrate utilization in most of the global surface ocean, the Southern ocean surface being an important exception.
Abstract: We report analyses of the nitrogen isotopic composition of nitrate in the eastern Indian and Pacific sectors of the Southern Ocean. In this paper, we focus on the subsurface data as well as data from the deep waters of other ocean basins. Nitrate δ15N is relatively invariant in much of the abyssal ocean (i.e., below 2.5 km), with a value of 4.8±0.2‰ observed in Lower Circumpolar Deep Water, North Atlantic Deep Water, and central Pacific deep water. The isotopic invariance of deep ocean nitrate stems fundamentally from the completeness of nitrate utilization in most of the global surface ocean, the Southern Ocean surface being an important exception. In the Subantarctic Zone (north of the Polar Frontal Zone) the nitrate δ15N of Upper Circumpolar Deep Water is ∼0.7‰ greater than that of Lower Circumpolar Deep Water. This isotopic enrichment appears to result from denitrification in the low-latitude water masses with which Upper Circumpolar Deep Water communicates. The isotopic enrichment of Upper Circumpolar Deep Water is diminished in the Antarctic, probably because of the remineralization of sinking organic N, which has a low δ15N in the Antarctic. Relative to the other water masses of the Southern Ocean, the Subantarctic thermocline has a very low nitrate δ15N for its nitrate concentration because of exchange with the low-latitude thermocline, where this isotopic signature appears to originate. This signature of the low-latitude thermocline has two probable causes: (1) mixing with low-nitrate surface water and (2) the oxidation of newly fixed N.

282 citations

Journal ArticleDOI
13 May 2004-Nature
TL;DR: From coral records and simulations with a coupled atmosphere–ocean circulation model, it is concluded that a tendency towards the high-index state of the North Atlantic Oscillation during the last interglacial period contributed to the larger amplitude of the seasonal cycle in the Middle East.
Abstract: The last interglacial period (about 125,000 years ago) is thought to have been at least as warm as the present climate. Owing to changes in the Earth's orbit around the Sun, it is thought that insolation in the Northern Hemisphere varied more strongly than today on seasonal timescales, which would have led to corresponding changes in the seasonal temperature cycle. Here we present seasonally resolved proxy records using corals from the northernmost Red Sea, which record climate during the last interglacial period, the late Holocene epoch and the present. We find an increased seasonality in the temperature recorded in the last interglacial coral. Today, climate in the northern Red Sea is sensitive to the North Atlantic Oscillation, a climate oscillation that strongly influences winter temperatures and precipitation in the North Atlantic region. From our coral records and simulations with a coupled atmosphere-ocean circulation model, we conclude that a tendency towards the high-index state of the North Atlantic Oscillation during the last interglacial period, which is consistent with European proxy records, contributed to the larger amplitude of the seasonal cycle in the Middle East.

282 citations

Journal ArticleDOI
TL;DR: Results demonstrate that processing of musical syntax interacts with the processing of linguistic syntax, and that this interaction is not due to a general effect of deviance-related negativities that precede an LAN.
Abstract: The present study investigated simultaneous processing of language and music using visually presented sentences and auditorily presented chord sequences. Music-syntactically regular and irregular chord functions were presented synchronously with syntactically correct or incorrect words, or with words that had either a high or a low semantic cloze probability. Music-syntactically irregular chords elicited an early right anterior negativity (ERAN). Syntactically incorrect words elicited a left anterior negativity (LAN). The LAN was clearly reduced when words were presented simultaneously with music-syntactically irregular chord functions. Processing of high and low cloze-probability words as indexed by the N400 was not affected by the presentation of irregular chord functions. In a control experiment, the LAN was not affected by physically deviant tones that elicited a mismatch negativity (MMN). Results demonstrate that processing of musical syntax (as reflected in the ERAN) interacts with the processing of linguistic syntax (as reflected in the LAN), and that this interaction is not due to a general effect of deviance-related negativities that precede an LAN. Findings thus indicate a strong overlap of neural resources involved in the processing of syntax in language and music.

282 citations

Journal ArticleDOI
TL;DR: In vivo interobserver and interscan studies on low-dose data from eight clinical metastasis patients revealed that clinically significant volume change can be detected reliably and with negligible computation time by the presented methods.
Abstract: Volumetric growth assessment of pulmonary lesions is crucial to both lung cancer screening and oncological therapy monitoring. While several methods for small pulmonary nodules have previously been presented, the segmentation of larger tumors that appear frequently in oncological patients and are more likely to be complexly interconnected with lung morphology has not yet received much attention. We present a fast, automated segmentation method that is based on morphological processing and is suitable for both small and large lesions. In addition, the proposed approach addresses clinical challenges to volume assessment such as variations in imaging protocol or inspiration state by introducing a method of segmentation-based partial volume analysis (SPVA) that follows on the segmentation procedure. Accuracy and reproducibility studies were performed to evaluate the new algorithms. In vivo interobserver and interscan studies on low-dose data from eight clinical metastasis patients revealed that clinically significant volume change can be detected reliably and with negligible computation time by the presented methods. In addition, phantom studies were conducted. Based on the segmentation performed with the proposed method, the performance of the SPVA volumetry method was compared with the conventional technique on a phantom that was scanned with different dosages and reconstructed with varying parameters. Both systematic and absolute errors were shown to be reduced substantially by the SPVA method. The method was especially successful in accounting for slice thickness and reconstruction kernel variations, where the median error was more than halved in comparison to the conventional approach.

281 citations


Authors

Showing all 14961 results

NameH-indexPapersCitations
Roger Y. Tsien163441138267
Klaus-Robert Müller12976479391
Ron Kikinis12668463398
Ulrich S. Schubert122222985604
Andreas Richter11076948262
Michael Böhm10875566103
Juan Bisquert10745046267
John P. Sumpter10126646184
Jos Lelieveld10057037657
Michael Schulz10075950719
Peter Singer9470237128
Charles R. Tyler9232531724
John P. Burrows9081536169
Hans-Peter Kriegel8944473932
Harald Haas8575034927
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023343
2022709
20212,106
20202,309
20192,191
20181,965