Institution
University of British Columbia
Education•Vancouver, British Columbia, Canada•
About: University of British Columbia is a education organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 89939 authors who have published 209679 publications receiving 9226862 citations. The organization is also known as: UBC & The University of British Columbia.
Papers published on a yearly basis
Papers
More filters
TL;DR: Key hypotheses in the literature pertaining to chronic grief and resilience were tested by identifying the preloss predictors of each pattern and chronic grief was associated with preloss dependency and resilience with pre Loss acceptance of death and belief in a just world.
Abstract: The vast majority of bereavement research is conducted after a loss has occurred. Thus, knowledge of the divergent trajectories of grieving or their antecedent predictors is lacking. This study gathered prospective data on 205 individuals several years prior to the death of their spouse and at 6- and 18-months postloss. Five core bereavement patterns were identified: common grief, chronic grief, chronic depression, improvement during bereavement, and resilience. Common grief was relatively infrequent, and the resilient pattern most frequent. The authors tested key hypotheses in the literature pertaining to chronic grief and resilience by identifying the preloss predictors of each pattern. Chronic grief was associated with preloss dependency and resilience with preloss acceptance of death and belief in a just world.
878 citations
University of British Columbia1, University of Zurich2, Northwestern University3, Washington University in St. Louis4, Uppsala University5, University of Sydney6, Medical University of Vienna7, Indiana University8, University of New South Wales9, Aarhus University10, University of Sheffield11, VU University Amsterdam12, University College London13, University of Antwerp14, Walton Centre15, Mayo Clinic16, University of Pennsylvania17, University of Manchester18
TL;DR: A system of nosology was introduced that grouped the FTLD subtypes into broad categories, based on the molecular defect that is most characteristic, according to current evidence, and provided a concise and consistent terminology that has now been widely adopted in the literature.
Abstract: Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration : an update
878 citations
Washington University in St. Louis1, University of British Columbia2, Wellcome Trust3, Clemson University4, National Institutes of Health5, Yeshiva University6, Baylor College of Medicine7, University of Texas at San Antonio8, Pfizer9, Roswell Park Cancer Institute10, Children's Hospital Oakland Research Institute11, Institute for Systems Biology12, Fred Hutchinson Cancer Research Center13, University of Pennsylvania14, United States Department of Energy15, Stanford University16, University of California, Santa Cruz17, University of Kiel18, University of California, Los Angeles19, Keio University20, Max Planck Society21
TL;DR: The construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions are reported.
Abstract: The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.
876 citations
TL;DR: The addition of enfuvirtide to an optimized antiretroviral and immunologic benefit through 24 weeks in patients who had previously received multiple antireTroviral drugs and had multidrug-resistant HIV-1 infection.
Abstract: Background The T-20 vs. Optimized Regimen Only Study 1 (TORO 1) was a randomized, open-label, phase 3 study of enfuvirtide (T-20), a human immunodeficiency virus type 1 (HIV-1) fusion inhibitor. Methods Patients from 48 sites in the United States, Canada, Mexico, and Brazil with at least six months of previous treatment with agents in three classes of antiretroviral drugs, resistance to drugs in these classes, or both, and with at least 5000 copies of HIV-1 RNA per milliliter of plasma were randomly assigned in a 2:1 ratio to receive enfuvirtide plus an optimized background regimen of three to five antiretroviral drugs or such a regimen alone (control group). The primary efficacy end point was the change in the plasma HIV-1 RNA level from base line to week 24. Results A total of 501 patients underwent randomization, and 491 received at least one dose of study drug and had at least one measurement of plasma HIV-1 RNA after treatment began. The two groups were balanced in terms of the median base-line HIV-1...
876 citations
TL;DR: The methods presented in this paper are aimed to overcome numerical difficulties of closed mathematical solutions of the frequency-dependent line equations in the time domain.
Abstract: The parameters of transmission lines with ground return are highly dependent on the frequency. Accurate modelling of this frequency dependence over the entire frequency range of the signals is of essential importance for the correct simulation of electromagnetic transient conditions. Closed mathematical solutions of the frequency-dependent line equations in the time domain are very difficult. Numerical approximation techniques are thus required for practical solutions. The oscillatory nature of the problem, however, makes ordinary numerical techniques very susceptible to instability and to accuracy errors. The, methods presented in this paper are aimed to overcome these numerical difficulties.
876 citations
Authors
Showing all 90682 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gordon H. Guyatt | 231 | 1620 | 228631 |
| John C. Morris | 183 | 1441 | 168413 |
| Douglas Scott | 178 | 1111 | 185229 |
| John R. Yates | 177 | 1036 | 129029 |
| Deborah J. Cook | 173 | 907 | 148928 |
| Richard A. Gibbs | 172 | 889 | 249708 |
| Evan E. Eichler | 170 | 567 | 150409 |
| James F. Sallis | 169 | 825 | 144836 |
| Michael Snyder | 169 | 840 | 130225 |
| Jiawei Han | 168 | 1233 | 143427 |
| Michael Kramer | 167 | 1713 | 127224 |
| Bruce L. Miller | 163 | 1153 | 115975 |
| Peter A. R. Ade | 162 | 1387 | 138051 |
| Marc W. Kirschner | 162 | 457 | 102145 |
| Kaj Blennow | 160 | 1845 | 116237 |