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Institution

University of British Columbia

EducationVancouver, British Columbia, Canada
About: University of British Columbia is a education organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 89939 authors who have published 209679 publications receiving 9226862 citations. The organization is also known as: UBC & The University of British Columbia.


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Journal ArticleDOI
TL;DR: The trial did not meet the predefined criteria for noninferiority but showed similar rates of recurrent stroke with ASA-ERDP and with clopidogrel, and there is no evidence that either of the two treatments was superior to the other in the prevention of recurrent strokes.
Abstract: BACKGROUND: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel. METHODS: In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive 25 mg of aspirin plus 200 mg of extended-release dipyridamole twice daily or to receive 75 mg of clopidogrel daily. The primary outcome was first recurrence of stroke. The secondary outcome was a composite of stroke, myocardial infarction, or death from vascular causes. Sequential statistical testing of noninferiority (margin of 1.075), followed by superiority testing, was planned. RESULTS: A total of 20,332 patients were followed for a mean of 2.5 years. Recurrent stroke occurred in 916 patients (9.0%) receiving ASA-ERDP and in 898 patients (8.8%) receiving clopidogrel (hazard ratio, 1.01; 95% confidence interval [CI], 0.92 to 1.11). The secondary outcome occurred in 1333 patients (13.1%) in each group (hazard ratio for ASA-ERDP, 0.99; 95% CI, 0.92 to 1.07). There were more major hemorrhagic events among ASA-ERDP recipients (419 [4.1%]) than among clopidogrel recipients (365 [3.6%]) (hazard ratio, 1.15; 95% CI, 1.00 to 1.32), including intracranial hemorrhage (hazard ratio, 1.42; 95% CI, 1.11 to 1.83). The net risk of recurrent stroke or major hemorrhagic event was similar in the two groups (1194 ASA-ERDP recipients [11.7%], vs. 1156 clopidogrel recipients [11.4%]; hazard ratio, 1.03; 95% CI, 0.95 to 1.11). CONCLUSIONS: The trial did not meet the predefined criteria for noninferiority but showed similar rates of recurrent stroke with ASA-ERDP and with clopidogrel. There is no evidence that either of the two treatments was superior to the other in the prevention of recurrent stroke. (ClinicalTrials.gov number, NCT00153062.)

853 citations

Journal ArticleDOI
TL;DR: There is an inadequate evidence base for doing "evidence-based" KTE for health policy decision making, and either KTE must be reconceptualized, or strategies must be evaluated more rigorously to produce a richerevidence base for future activity.
Abstract: Knowledge transfer and exchange (KTE) is as an interactive process involving the interchange of knowledge between research users and researcher producers. Despite many strategies for KTE, it is not clear which ones should be used in which contexts. This article is a review and synthesis of the KTE literature on health care policy. The review examined and summarized KTE's current evidence base for KTE. It found that about 20 percent of the studies reported on a real-world application of a KTE strategy, and fewer had been formally evaluated. At this time there is an inadequate evidence base for doing “evidence-based” KTE for health policy decision making. Either KTE must be reconceptualized, or strategies must be evaluated more rigorously to produce a richer evidence base for future activity.

853 citations

Journal ArticleDOI
Seb Oliver1, James J. Bock2, James J. Bock3, Bruno Altieri4, Alexandre Amblard5, V. Arumugam6, Herve Aussel7, Tom Babbedge8, Alexandre Beelen9, Matthieu Béthermin9, Matthieu Béthermin7, Andrew Blain3, Alessandro Boselli10, C. Bridge3, Drew Brisbin11, V. Buat10, Denis Burgarella10, N. Castro-Rodríguez12, N. Castro-Rodríguez13, Antonio Cava14, P. Chanial7, Michele Cirasuolo15, David L. Clements8, A. Conley16, L. Conversi4, Asantha Cooray17, Asantha Cooray3, C. D. Dowell2, C. D. Dowell3, Elizabeth Dubois1, Eli Dwek18, Simon Dye19, Stephen Anthony Eales20, David Elbaz7, Duncan Farrah1, A. Feltre21, P. Ferrero13, P. Ferrero12, N. Fiolet9, N. Fiolet22, M. Fox8, Alberto Franceschini21, Walter Kieran Gear20, E. Giovannoli10, Jason Glenn16, Yan Gong17, E. A. González Solares23, Matthew Joseph Griffin20, Mark Halpern24, Martin Harwit, Evanthia Hatziminaoglou, Sebastien Heinis10, Peter Hurley1, Ho Seong Hwang7, A. Hyde8, Edo Ibar15, O. Ilbert10, K. G. Isaak25, Rob Ivison6, Rob Ivison15, Guilaine Lagache9, E. Le Floc'h7, L. R. Levenson3, L. R. Levenson2, B. Lo Faro21, Nanyao Y. Lu3, S. C. Madden7, Bruno Maffei26, Georgios E. Magdis7, G. Mainetti21, Lucia Marchetti21, G. Marsden24, J. Marshall3, J. Marshall2, A. M. J. Mortier8, Hien Nguyen2, Hien Nguyen3, B. O'Halloran8, Alain Omont22, Mat Page27, P. Panuzzo7, Andreas Papageorgiou20, H. Patel8, Chris Pearson28, Chris Pearson29, Ismael Perez-Fournon12, Ismael Perez-Fournon13, Michael Pohlen20, Jonathan Rawlings27, Gwenifer Raymond20, Dimitra Rigopoulou28, Dimitra Rigopoulou30, L. Riguccini7, D. Rizzo8, Giulia Rodighiero21, Isaac Roseboom1, Isaac Roseboom6, Michael Rowan-Robinson8, M. Sanchez Portal4, Benjamin L. Schulz3, Douglas Scott24, Nick Seymour27, Nick Seymour31, D. L. Shupe3, A. J. Smith1, Jamie Stevens32, M. Symeonidis27, Markos Trichas33, K. E. Tugwell27, Mattia Vaccari21, Ivan Valtchanov4, Joaquin Vieira3, Marco P. Viero3, L. Vigroux22, Lifan Wang1, Robyn L. Ward1, Julie Wardlow17, G. Wright15, C. K. Xu3, Michael Zemcov2, Michael Zemcov3 
TL;DR: The Herschel Multi-tiered Extragalactic Survey (HerMES) is a legacy program designed to map a set of nested fields totalling ∼380deg^2 as mentioned in this paper.
Abstract: The Herschel Multi-tiered Extragalactic Survey (HerMES) is a legacy programme designed to map a set of nested fields totalling ∼380 deg^2. Fields range in size from 0.01 to ∼20 deg^2, using the Herschel-Spectral and Photometric Imaging Receiver (SPIRE) (at 250, 350 and 500 μm) and the Herschel-Photodetector Array Camera and Spectrometer (PACS) (at 100 and 160 μm), with an additional wider component of 270 deg^2 with SPIRE alone. These bands cover the peak of the redshifted thermal spectral energy distribution from interstellar dust and thus capture the reprocessed optical and ultraviolet radiation from star formation that has been absorbed by dust, and are critical for forming a complete multiwavelength understanding of galaxy formation and evolution. The survey will detect of the order of 100 000 galaxies at 5σ in some of the best-studied fields in the sky. Additionally, HerMES is closely coordinated with the PACS Evolutionary Probe survey. Making maximum use of the full spectrum of ancillary data, from radio to X-ray wavelengths, it is designed to facilitate redshift determination, rapidly identify unusual objects and understand the relationships between thermal emission from dust and other processes. Scientific questions HerMES will be used to answer include the total infrared emission of galaxies, the evolution of the luminosity function, the clustering properties of dusty galaxies and the properties of populations of galaxies which lie below the confusion limit through lensing and statistical techniques. This paper defines the survey observations and data products, outlines the primary scientific goals of the HerMES team, and reviews some of the early results.

852 citations

Journal ArticleDOI
TL;DR: In this article, the authors examined the pricing behavior of securities of firms which repurchase their own shares and found that repurchases via tender offer are followed by abnormal increases in earnings per share and that mainly small firms engage in repurchase tender offers.

852 citations

Journal ArticleDOI
Patrick J. Keeling1, Patrick J. Keeling2, Fabien Burki2, Heather M. Wilcox3, Bassem Allam4, Eric E. Allen5, Linda A. Amaral-Zettler6, Linda A. Amaral-Zettler7, E. Virginia Armbrust8, John M. Archibald9, John M. Archibald1, Arvind K. Bharti10, Callum J. Bell10, Bank Beszteri11, Kay D. Bidle12, Connor Cameron10, Lisa Campbell13, David A. Caron14, Rose Ann Cattolico8, Jackie L. Collier4, Kathryn J. Coyne15, Simon K. Davy16, Phillipe Deschamps17, Sonya T. Dyhrman18, Bente Edvardsen19, Ruth D. Gates20, Christopher J. Gobler4, Spencer J. Greenwood21, Stephanie Guida10, Jennifer L. Jacobi10, Kjetill S. Jakobsen19, Erick R. James2, Bethany D. Jenkins22, Uwe John11, Matthew D. Johnson23, Andrew R. Juhl18, Anja Kamp24, Anja Kamp25, Laura A. Katz26, Ronald P. Kiene27, Alexander Kudryavtsev28, Alexander Kudryavtsev29, Brian S. Leander2, Senjie Lin30, Connie Lovejoy31, Denis H. Lynn2, Denis H. Lynn32, Adrian Marchetti33, George B. McManus30, Aurora M. Nedelcu34, Susanne Menden-Deuer22, Cristina Miceli35, Thomas Mock36, Marina Montresor37, Mary Ann Moran38, Shauna A. Murray39, Govind Nadathur40, Satoshi Nagai, Peter B. Ngam10, Brian Palenik5, Jan Pawlowski28, Giulio Petroni41, Gwenael Piganeau42, Matthew C. Posewitz43, Karin Rengefors44, Giovanna Romano37, Mary E. Rumpho30, Tatiana A. Rynearson22, Kelly B. Schilling10, Declan C. Schroeder, Alastair G. B. Simpson9, Alastair G. B. Simpson1, Claudio H. Slamovits1, Claudio H. Slamovits9, David Roy Smith45, G. Jason Smith46, Sarah R. Smith5, Heidi M. Sosik23, Peter Stief25, Edward C. Theriot47, Scott N. Twary48, Pooja E. Umale10, Daniel Vaulot49, Boris Wawrik50, Glen L. Wheeler51, William H. Wilson52, Yan Xu53, Adriana Zingone37, Alexandra Z. Worden3, Alexandra Z. Worden1 
Canadian Institute for Advanced Research1, University of British Columbia2, Monterey Bay Aquarium Research Institute3, Stony Brook University4, University of California, San Diego5, Brown University6, Marine Biological Laboratory7, University of Washington8, Dalhousie University9, National Center for Genome Resources10, Alfred Wegener Institute for Polar and Marine Research11, Rutgers University12, Texas A&M University13, University of Southern California14, University of Delaware15, Victoria University of Wellington16, University of Paris-Sud17, Columbia University18, University of Oslo19, University of Hawaii at Manoa20, University of Prince Edward Island21, University of Rhode Island22, Woods Hole Oceanographic Institution23, Jacobs University Bremen24, Max Planck Society25, Smith College26, University of South Alabama27, University of Geneva28, Saint Petersburg State University29, University of Connecticut30, Laval University31, University of Guelph32, University of North Carolina at Chapel Hill33, University of New Brunswick34, University of Camerino35, University of East Anglia36, Stazione Zoologica Anton Dohrn37, University of Georgia38, University of Technology, Sydney39, University of Puerto Rico40, University of Pisa41, Centre national de la recherche scientifique42, Colorado School of Mines43, Lund University44, University of Western Ontario45, California State University46, University of Texas at Austin47, Los Alamos National Laboratory48, Pierre-and-Marie-Curie University49, University of Oklahoma50, Plymouth Marine Laboratory51, Bigelow Laboratory For Ocean Sciences52, Princeton University53
TL;DR: In this paper, the authors describe a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans and their biology, evolution, and ecology.
Abstract: Current sampling of genomic sequence data from eukaryotes is relatively poor, biased, and inadequate to address important questions about their biology, evolution, and ecology; this Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans.

852 citations


Authors

Showing all 90682 results

NameH-indexPapersCitations
Gordon H. Guyatt2311620228631
John C. Morris1831441168413
Douglas Scott1781111185229
John R. Yates1771036129029
Deborah J. Cook173907148928
Richard A. Gibbs172889249708
Evan E. Eichler170567150409
James F. Sallis169825144836
Michael Snyder169840130225
Jiawei Han1681233143427
Michael Kramer1671713127224
Bruce L. Miller1631153115975
Peter A. R. Ade1621387138051
Marc W. Kirschner162457102145
Kaj Blennow1601845116237
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023307
20221,209
202113,228
202012,052
201910,934