University of British Columbia

About: University of British Columbia is a education organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 89939 authors who have published 209679 publications receiving 9226862 citations. The organization is also known as: UBC & The University of British Columbia.

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Abstract: The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.

Convex Analysis and Monotone Operator Theory in Hilbert Spaces

Abstract: This book provides a largely self-contained account of the main results of convex analysis and optimization in Hilbert space. A concise exposition of related constructive fixed point theory is presented, that allows for a wide range of algorithms to construct solutions to problems in optimization, equilibrium theory, monotone inclusions, variational inequalities, best approximation theory, and convex feasibility. The book is accessible to a broad audience, and reaches out in particular to applied scientists and engineers, to whom these tools have become indispensable.

Abiraterone and Increased Survival in Metastatic Prostate Cancer

Abstract: BACKGROUND Biosynthesis of extragonadal androgen may contribute to the progression of castration-resistant prostate cancer. We evaluated whether abiraterone acetate, an inhibitor of androgen biosynthesis, prolongs overall survival among patients with metastatic castration-resistant prostate cancer who have received chemotherapy. METHODS We randomly assigned, in a 2:1 ratio, 1195 patients who had previously received docetaxel to receive 5 mg of prednisone twice daily with either 1000 mg of abiraterone acetate (797 patients) or placebo (398 patients). The primary end point was overall survival. The secondary end points included time to prostate-specific antigen (PSA) progression (elevation in the PSA level according to prespecified criteria), progression-free survival according to radiologic findings based on prespecified criteria, and the PSA response rate. RESULTS After a median follow-up of 12.8 months, overall survival was longer in the abiraterone acetate–prednisone group than in the placebo–prednisone group (14.8 months vs. 10.9 months; hazard ratio, 0.65; 95% confidence interval, 0.54 to 0.77; P<0.001). Data were unblinded at the interim analysis, since these results exceeded the preplanned criteria for study termination. All secondary end points, including time to PSA progression (10.2 vs. 6.6 months; P<0.001), progression-free survival (5.6 months vs. 3.6 months; P<0.001), and PSA response rate (29% vs. 6%, P<0.001), favored the treatment group. Mineralocorticoid-related adverse events, including fluid retention, hypertension, and hypokalemia, were more frequently reported in the abiraterone acetate–prednisone group than in the placebo–prednisone group. CONCLUSIONS The inhibition of androgen biosynthesis by abiraterone acetate prolonged overall survival among patients with metastatic castration-resistant prostate cancer who previously received chemotherapy. (Funded by Cougar Biotechnology; COU-AA-301 ClinicalTrials.gov number, NCT00638690.)

First Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Preliminary Maps and Basic Results

Abstract: We present full sky microwave maps in five bands (23 to 94 GHz) from the WMAP first year sky survey. Calibration errors are 1 per mode to l=658. The temperature-polarization cross-power spectrum reveals both acoustic features and a large angle correlation from reionization. The optical depth of reionization is 0.17 +/- 0.04, which implies a reionization epoch of 180+220-80 Myr (95% CL) after the Big Bang at a redshift of 20+10-9 (95% CL) for a range of ionization scenarios. This early reionization is incompatible with the presence of a significant warm dark matter density. The age of the best-fit universe is 13.7 +/- 0.2 Gyr old. Decoupling was 379+8-7 kyr after the Big Bang at a redshift of 1089 +/- 1. The thickness of the decoupling surface was dz=195 +/- 2. The matter density is Omega_m h^2 = 0.135 +0.008 -0.009, the baryon density is Omega_b h^2 = 0.0224 +/- 0.0009, and the total mass-energy of the universe is Omega_tot = 1.02 +/- 0.02. The spectral index of scalar fluctuations is fit as n_s = 0.93 +/- 0.03 at wavenumber k_0 = 0.05 Mpc^-1, with a running index slope of dn_s/d ln k = -0.031 +0.016 -0.018 in the best-fit model. This flat universe model is composed of 4.4% baryons, 22% dark matter and 73% dark energy. The dark energy equation of state is limited to w<-0.78 (95% CL). Inflation theory is supported with n_s~1, Omega_tot~1, Gaussian random phases of the CMB anisotropy, and superhorizon fluctuations. An admixture of isocurvature modes does not improve the fit. The tensor-to-scalar ratio is r(k_0=0.002 Mpc^-1)<0.90 (95% CL).