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Institution

University of British Columbia

EducationVancouver, British Columbia, Canada
About: University of British Columbia is a education organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 89939 authors who have published 209679 publications receiving 9226862 citations. The organization is also known as: UBC & The University of British Columbia.


Papers
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Journal ArticleDOI
10 Oct 2013-Cell
TL;DR: Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM.

3,593 citations

Journal ArticleDOI
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
Abstract: Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are present in virtually every life form, as an important component of (innate) immune defenses. These host-defense peptides provide a template for two separate classes of antimicrobial drugs. Direct-acting antimicrobial host-defense peptides can be rapid-acting and potent, and possess an unusually broad spectrum of activity; consequently, they have prospects as new antibiotics, although clinical trials to date have shown efficacy only as topical agents. But for these compounds to fulfill their therapeutic promise and overcome clinical setbacks, further work is needed to understand their mechanisms of action and reduce the potential for unwanted toxicity, to make them more resistant to protease degradation and improve serum half-life, as well as to devise means of manufacturing them on a large scale in a consistent and cost-effective manner. In contrast, the role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.

3,556 citations

Journal ArticleDOI
TL;DR: A large-scale meta-analysis of experimental enrichments shows that P limitation is equally strong across these major habitats and that N and P limitation are equivalent within both terrestrial and freshwater systems.
Abstract: The cycles of the key nutrient elements nitrogen (N) and phosphorus (P) have been massively altered by anthropogenic activities. Thus, it is essential to understand how photosynthetic production across diverse ecosystems is, or is not, limited by N and P. Via a large-scale meta-analysis of experimental enrichments, we show that P limitation is equally strong across these major habitats and that N and P limitation are equivalent within both terrestrial and freshwater systems. Furthermore, simultaneous N and P enrichment produces strongly positive synergistic responses in all three environments. Thus, contrary to some prevailing paradigms, freshwater, marine and terrestrial ecosystems are surprisingly similar in terms of N and P limitation.

3,543 citations

Journal ArticleDOI
TL;DR: DNA microarrays can be used to formulate a molecular predictor of survival after chemotherapy for diffuse large-B-cell lymphoma and this gene-based predictor and the international prognostic index were independent prognostic indicators.
Abstract: Background The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to develop a molecular predictor of survival. Methods Biopsy samples of diffuse large-B-cell lymphoma from 240 patients were examined for gene expression with the use of DNA microarrays and analyzed for genomic abnormalities. Subgroups with distinctive gene-expression profiles were defined on the basis of hierarchical clustering. A molecular predictor of risk was constructed with the use of genes with expression patterns that were associated with survival in a preliminary group of 160 patients and was then tested in a validation group of 80 patients. The accuracy of this predictor was compared with that of the international prognostic index. Results Three gene-expression subgroups — germinal-center B-cell–like, activated B-cell–like, and type 3 diffuse large-B-cell lymphoma — were identified. Two common oncogeni...

3,510 citations

Journal ArticleDOI
TL;DR: In this article, a large collection of images with ground truth labels is built to be used for object detection and recognition research, such data is useful for supervised learning and quantitative evaluation.
Abstract: We seek to build a large collection of images with ground truth labels to be used for object detection and recognition research. Such data is useful for supervised learning and quantitative evaluation. To achieve this, we developed a web-based tool that allows easy image annotation and instant sharing of such annotations. Using this annotation tool, we have collected a large dataset that spans many object categories, often containing multiple instances over a wide variety of images. We quantify the contents of the dataset and compare against existing state of the art datasets used for object recognition and detection. Also, we show how to extend the dataset to automatically enhance object labels with WordNet, discover object parts, recover a depth ordering of objects in a scene, and increase the number of labels using minimal user supervision and images from the web.

3,501 citations


Authors

Showing all 90682 results

NameH-indexPapersCitations
Gordon H. Guyatt2311620228631
John C. Morris1831441168413
Douglas Scott1781111185229
John R. Yates1771036129029
Deborah J. Cook173907148928
Richard A. Gibbs172889249708
Evan E. Eichler170567150409
James F. Sallis169825144836
Michael Snyder169840130225
Jiawei Han1681233143427
Michael Kramer1671713127224
Bruce L. Miller1631153115975
Peter A. R. Ade1621387138051
Marc W. Kirschner162457102145
Kaj Blennow1601845116237
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023307
20221,209
202113,228
202012,052
201910,934