University of British Columbia

About: University of British Columbia is a education organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 89939 authors who have published 209679 publications receiving 9226862 citations. The organization is also known as: UBC & The University of British Columbia.

The Varnes classification of landslide types, an update

Abstract: The goal of this article is to revise several aspects of the well-known classification of landslides, developed by Varnes (1978). The primary recommendation is to modify the definition of landslide-forming materials, to provide compatibility with accepted geotechnical and geological terminology of rocks and soils. Other, less important modifications of the classification system are suggested, resulting from recent developments of the landslide science. The modified Varnes classification of landslides has 32 landslide types, each of which is backed by a formal definition. The definitions should facilitate backward compatibility of the system as well as possible translation to other languages. Complex landslides are not included as a separate category type, but composite types can be constructed by the user of the classification by combining two or more type names, if advantageous.

Three Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Polarization Analysis

Abstract: The Wilkinson Microwave Anisotropy Probe (WMAP) has mapped the entire sky in five frequency bands between 23 and 94 GHz with polarization-sensitive radiometers. We present 3 year full-sky maps of the polarization and analyze them for foreground emission and cosmological implications. These observations open up a new window for understanding how the universe began and help set a foundation for future observations. WMAP observes significant levels of polarized foreground emission due to both Galactic synchrotron radiation and thermal dust emission. Synchrotron radiation is the dominant signal at l < 50 and ν 40 GHz, while thermal dust emission is evident at 94 GHz. The least contaminated channel is at 61 GHz. We present a model of polarized foreground emission that captures the large angular scale characteristics of the microwave sky. After applying a Galactic mask that cuts 25.7% of the sky, we show that the high Galactic latitude rms polarized foreground emission, averaged over l = 4-6, ranges from ≈5 μK at 22 GHz to 0.6 μK at 61 GHz. By comparison, the levels of intrinsic CMB polarization for a ΛCDM model with an optical depth of τ = 0.09 and assumed tensor-to-scalar ratio r = 0.3 are ≈0.3 μK for E-mode polarization and ≈0.1 μK for B-mode polarization. To analyze the maps for CMB polarization at l < 16, we subtract a model of the foreground emission that is based primarily on a scaling WMAP's 23 GHz map. In the foreground-corrected maps, we detect l(l + 1)C/2π = 0.086 ± 0.029 (μK)2. This is interpreted as the result of rescattering of the CMB by free electrons released during reionization at zr = 10.9 for a model with instantaneous reionization. By computing the likelihood of just the EE data as a function of τ we find τ = 0.10 ± 0.03. When the same EE data are used in the full six-parameter fit to all WMAP data (TT, TE, EE), we find τ = 0.09 ± 0.03. Marginalization over the foreground subtraction affects this value by δτ < 0.01. We see no evidence for B modes, limiting them to l(l + 1)C/2π = -0.04 ± 0.03 (μK)2. We perform a template fit to the E-mode and B-mode data with an approximate model for the tensor scalar ratio. We find that the limit from the polarization signals alone is r < 2.2 (95% CL), where r is evaluated at k = 0.002 Mpc-1. This corresponds to a limit on the cosmic density of gravitational waves of ΩGWh2 < 5 × 10-12. From the full WMAP analysis, we find r < 0.55 (95% CL) corresponding to a limit of ΩGWh2 < 1 × 10-12 (95% CL). The limit on r is approaching the upper bound of predictions for some of the simplest models of inflation, r ~ 0.3.

Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer

Abstract: Background Gene expression profiling of breast cancer has identified two biologically distinct estrogen receptor (ER)positive subtypes of breast cancer: luminal A and luminal B. Luminal B tumors have higher proliferation and poorer prognosis than luminal A tumors. In this study, we developed a clinically practical immunohistochemistry assay to distinguish luminal B from luminal A tumors and investigated its ability to separate tumors according to breast cancer recurrence-free and disease-specific survival. Methods Tumors from a cohort of 357 patients with invasive breast carcinomas were subtyped by gene expression profile. Hormone receptor status, HER2 status, and the Ki67 index (percentage of Ki67-positive cancer nuclei) were determined immunohistochemically. Receiver operating characteristic curves were used to determine the Ki67 cut point to distinguish luminal B from luminal A tumors. The prognostic value of the immunohistochemical assignment for breast cancer recurrence-free and disease-specific survival was investigated with an independent tissue microarray series of 4046 breast cancers by use of Kaplan – Meier curves and multivariable Cox regression. Results Gene expression profiling classified 101 (28%) of the 357 tumors as luminal A and 69 (19%) as luminal B. The best Ki67 index cut point to distinguish luminal B from luminal A tumors was 13.25%. In an independent cohort of 4046 patients with breast cancer, 2847 had hormone receptor – positive tumors. When HER2 immunohistochemistry and the Ki67 index were used to subtype these 2847 tumors, we classified 1530 (59%, 95% confidence interval [CI] = 57% to 61%) as luminal A, 846 (33%, 95% CI = 31% to 34%) as luminal B, and 222 (9%, 95% CI = 7% to 10%) as luminal – HER2 positive. Luminal B and luminal – HER2-positive breast cancers were statistically significantly associated with poor breast cancer recurrence-free and disease-specific survival in all adjuvant systemic treatment categories. Of particular relevance are women who received tamoxifen as their sole adjuvant systemic therapy, among whom the 10-year breast cancer – specific survival was 79% (95% CI = 76% to 83%) for luminal A, 64% (95% CI = 59% to 70%) for luminal B, and 57% (95% CI = 47% to 69%) for luminal – HER2 subtypes. Conclusion Expression of ER, progesterone receptor, and HER2 proteins and the Ki67 index appear to distinguish

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Abstract: The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.