University of British Columbia

About: University of British Columbia is a education organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 89939 authors who have published 209679 publications receiving 9226862 citations. The organization is also known as: UBC & The University of British Columbia.

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

Abstract: Background In a single-group, phase 1b trial, avelumab plus axitinib resulted in objective responses in patients with advanced renal-cell carcinoma. This phase 3 trial involving previously...

Information security policy compliance: an empirical study of rationality-based beliefs and information security awareness

Abstract: Many organizations recognize that their employees, who are often considered the weakest link in information security, can also be great assets in the effort to reduce risk related to information security. Since employees who comply with the information security rules and regulations of the organization are the key to strengthening information security, understanding compliance behavior is crucial for organizations that want to leverage their human capital. This research identifies the antecedents of employee compliance with the information security policy (ISP) of an organization. Specifically, we investigate the rationality-based factors that drive an employee to comply with requirements of the ISP with regard to protecting the organization's information and technology resources. Drawing on the theory of planned behavior, we posit that, along with normative belief and self-efficacy, an employee's attitude toward compliance determines intention to comply with the ISP. As a key contribution, we posit that an employee's attitude is influenced by benefit of compliance, cost of compliance, and cost of noncompliance, which are beliefs about the overall assessment of consequences of compliance or noncompliance. We then postulate that these beliefs are shaped by the employee's outcome beliefs concerning the events that follow compliance or noncompliance: benefit of compliance is shaped by intrinsic benefit, safety of resources, and rewards, while cost of compliance is shaped by work impediment; and cost of noncompliance is shaped by intrinsic cost, vulnerability of resources, and sanctions. We also investigate the impact of information security awareness (ISA) on outcome beliefs and an employee's attitude toward compliance with the ISP. Our results show that an employee's intention to comply with the ISP is significantly influenced by attitude, normative beliefs, and self-efficacy to comply. Outcome beliefs significantly affect beliefs about overall assessment of consequences, and they, in turn, significantly affect an employee's attitude. Furthermore, ISA positively affects both attitude and outcome beliefs. As the importance of employees' following their organizations' information security rules and regulations increases, our study sheds light on the role of ISA and compliance-related beliefs in an organization's efforts to encourage compliance.

Strategies for Multivessel Revascularization in Patients with Diabetes

Abstract: Background In some randomized trials comparing revascularization strategies for patients with diabetes, coronary-artery bypass grafting (CABG) has had a better outcome than percutaneous coronary intervention (PCI). We sought to discover whether aggressive medical therapy and the use of drug-eluting stents could alter the revascularization approach for patients with diabetes and multivessel coronary artery disease. Methods In this randomized trial, we assigned patients with diabetes and multivessel coronary artery disease to undergo either PCI with drug-eluting stents or CABG. The patients were followed for a minimum of 2 years (median among survivors, 3.8 years). All patients were prescribed currently recommended medical therapies for the control of low-density lipoprotein cholesterol, systolic blood pressure, and glycated hemoglobin. The primary outcome measure was a composite of death from any cause, nonfatal myocardial infarction, or nonfatal stroke. Results From 2005 through 2010, we enrolled 1900 patients at 140 international centers. The patients’ mean age was 63.1±9.1 years, 29% were women, and 83% had threevessel disease. The primary outcome occurred more frequently in the PCI group (P = 0.005), with 5-year rates of 26.6% in the PCI group and 18.7% in the CABG group. The benefit of CABG was driven by differences in rates of both myocardial infarction (P<0.001) and death from any cause (P = 0.049). Stroke was more frequent in the CABG group, with 5-year rates of 2.4% in the PCI group and 5.2% in the CABG group (P = 0.03). Conclusions For patients with diabetes and advanced coronary artery disease, CABG was superior to PCI in that it significantly reduced rates of death and myocardial infarction, with a higher rate of stroke. (Funded by the National Heart, Lung, and Blood Institute and others; FREEDOM ClinicalTrials.gov number, NCT00086450.)

Primary production required to sustain global fisheries

Abstract: THE mean of reported annual world fisheries catches for 1988-1991 (94.3 million t) was split into 39 species groups, to which fractional trophic levels, ranging from 1.0 (edible algae) to 4.2 (tunas), were assigned, based on 48 published trophic models, providing a global coverage of six major aquatic ecosystem types. The primary production required to sustain each group of species was then computed based on a mean energy transfer efficiency between trophic levels of 10%, a value that was reestimated rather than assumed. The primary production required to sustain the reported catches, plus 27 million t of discarded bycatch, amounted to 8.0% of global aquatic primary production, nearly four times the previous estimate. By ecosystem type, the requirements were only 2% for open ocean systems, but ranged from 24 to 35% in fresh water, upwelling and shelf systems, justifying current concerns for sustainability and biodiversity.

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Abstract: Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different ways. We review the literature focusing on the correlation of AD neuropathologic changes (i.e. β-amyloid plaques and neurofibrillary tangles) with cognitive impairment. We discuss the various patterns of brain changes that have been observed in elderly individuals to provide a perspective for understanding AD clinicopathologic correlation and conclude that evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of Aβ plaques and neurofibrillary tangles. Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles.