University of Cagliari

About: University of Cagliari is a education organization based out in Cagliari, Italy. It is known for research contribution in the topics: Population & Dopamine. The organization has 11029 authors who have published 29046 publications receiving 771023 citations. The organization is also known as: Università degli Studi di Cagliari & Universita degli Studi di Cagliari.

Multiparticle azimuthal correlations in p -Pb and Pb-Pb collisions at the CERN Large Hadron Collider

Abstract: Measurements of multiparticle azimuthal correlations (cumulants) for charged particles in p-Pb at √sNN√=5.02 TeV and Pb-Pb at √sNN=2.76 TeV collisions are presented. They help address the question of whether there is evidence for global, flowlike, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a |Δη| gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high multiplicity, indicating the presence of global azimuthal correlations. The Pb-Pb values are higher than the p-Pb values at similar multiplicities. In both systems, the second harmonic four-particle cumulants exhibit a transition from positive to negative values when the multiplicity increases. The negative values allow for a measurement of v2{4} to be made, which is found to be higher in Pb-Pb collisions at similar multiplicities. The second harmonic six-particle cumulants are also found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find v2{4}≃v2{6}≠0 which is indicative of a Bessel-Gaussian function for the v2 distribution. For very high-multiplicity Pb-Pb collisions, we observe that the four- and six-particle cumulants become consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and Pb-Pb are measured. These are found to be similar for overlapping multiplicities, when a |Δη|>1.4 gap is placed.

/spl times/pipes Lite: a synthesis oriented design library for networks on chips

Abstract: The limited scalability of current bus topologies for systems on chips (SoCs) dictates the adoption of networks on chips (NoCs) as a scalable interconnection scheme. Current SoCs are highly heterogeneous in nature, denoting homogeneous, preconfigured NoCs as inefficient drop-in alternatives. While highly parametric, fully synthesizeable (soft) NoC building blocks appear as a good match for heterogeneous MPSoC architectures, the impact of instantiation-time flexibility on performance, power and silicon cost has not yet been quantified. The paper details /spl times/pipes Lite, a design flow for automatic generation of heterogeneous NoCs. /spl times/pipes Lite is based on highly customizable, high frequency and low latency NoC modules, that are fully synthesizeable. Synthesis results provide modules that are directly comparable, if not better, than the current published state-of-the-art NoCs in terms of area, power latency and target operating frequency measurements.

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

Abstract: Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the add ...

Structure-function relationships of temporins, small antimicrobial peptides from amphibian skin

Abstract: Temporins, antimicrobial peptides of 10-13 residues, were isolated from secretions of Rana temporaria [Simmaco, M., Mignogna, G., Canofeni, S., Miele, R., Mangoni, M.L. & Barra, D. (1996) Eur. J. Biochem. 242, 788-792]. These molecules are specific to this amphibian species, which is also able to secrete on its skin other antimicrobial peptides similar to those found in different Rana species. The effect of temporins A, B and D (13 residues, net charge +2), and H (10 residues, net charge +1 and +2, respectively) against both artificial membranes of differing lipid composition and bacteria has been investigated in order to gain insight into their mechanisms of action. The results indicate that: the lytic activity of temporins is not greatly affected by the membrane composition; temporins A and B allow the leakage of large-size molecules from the bacterial cells; temporin H renders both the outer and inner membrane of bacteria permeable to hydrophobic substances of low molecular mass; and temporin D, although devoid of antibacterial activity, has a cytotoxic effect on erythrocytes. The results allow important conclusions to be drawn about the minimal structural requirements for lytic efficiency and specificity of temporins.

Modeling and Supervisory Control of Railway Networks Using Petri Nets

Abstract: In this paper, we deal with the problem of modeling railway networks with Petri nets so as to apply the theory of supervisory control for discrete event systems to automatically design the system controller. We provide a modular representation of railway networks in terms of stations and tracks including sensors and semaphores. We first ensure safeness and local liveness imposing both generalized mutual exclusion constraints and constraints also involving the firing vector. The detailed model used in this first step can be abstracted, considering a higher level description of a railway network that belongs to the class of ES PR (extended simple sequential process with resources) nets and show that global liveness may be enforced by adding appropriate monitor places designed using siphon analysis. In our approach, this can be done without an exhaustive computation of all siphons and we can characterize the cases in which the procedure can be recursively applied, giving a simple test for closed-loop net to remain an ES PR net.