University of Cagliari

About: University of Cagliari is a education organization based out in Cagliari, Italy. It is known for research contribution in the topics: Population & Dopamine. The organization has 11029 authors who have published 29046 publications receiving 771023 citations. The organization is also known as: Università degli Studi di Cagliari & Universita degli Studi di Cagliari.

Pantographic metamaterials: an example of mathematically driven design and of its technological challenges

Abstract: In this paper, we account for the research efforts that have been started, for some among us, already since 2003, and aimed to the design of a class of exotic architectured, optimized (meta) materials. At the first stage of these efforts, as it often happens, the research was based on the results of mathematical investigations. The problem to be solved was stated as follows: determine the material (micro)structure governed by those equations that specify a desired behavior. Addressing this problem has led to the synthesis of second gradient materials. In the second stage, it has been necessary to develop numerical integration schemes and the corresponding codes for solving, in physically relevant cases, the chosen equations. Finally, it has been necessary to physically construct the theoretically synthesized microstructures. This has been possible by means of the recent developments in rapid prototyping technologies, which allow for the fabrication of some complex (micro)structures considered, up to now, to be simply some mathematical dreams. We show here a panorama of the results of our efforts (1) in designing pantographic metamaterials, (2) in exploiting the modern technology of rapid prototyping, and (3) in the mechanical testing of many real prototypes. Among the key findings that have been obtained, there are the following ones: pantographic metamaterials (1) undergo very large deformations while remaining in the elastic regime, (2) are very tough in resisting to damage phenomena, (3) exhibit robust macroscopic mechanical behavior with respect to minor changes in their microstructure and micromechanical properties, (4) have superior strength to weight ratio, (5) have predictable damage behavior, and (6) possess physical properties that are critically dictated by their geometry at the microlevel.

Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state.

Abstract: We have previously shown in non-deprived rats that feeding of an unfamiliar palatable food (Fonzies(R)) phasically stimulates in vivo dopamine (DA) transmission in the medial nucleus accumbens (NAc) and this effect undergoes habituation after a previous (24 h) Fonzies meal (Bassareo & Di Chiara 1997, J Neurosci, 17, 851-861) The present study shows that an unfamiliar food (Kinder(R)) with a taste and composition (milk chocolate) different from that of Fonzies, also induces a release of DA in the NAc subjected to one-trial habituation Habituation was taste specific as no cross-habituation was observed between Fonzies and Kinder In undeprived rats, a 40-min exposure to an intrinsic appetitive stimulus (food smell arising from a Fonzies-filled plastic box) also prevented the increase in dialysate DA associated with Fonzies feeding, and this effect was partially reversed by food deprivation Food deprivation also prevented habituation of Fonzies-induced increase of dialysate DA in the NAc Predictive association of an empty plastic box to Fonzies feeding resulted in the acquisition of appetitive properties by the box and in facilitation (rather than inhibition) of the phasic responsiveness of DA transmission to Fonzies feeding A 10-min pre-exposure to appetitive olfactory stimuli intrinsic to Fonzies still prevented, like a 40-min pre-exposure, the NAc DA response to Fonzies feeding; however, a 5-min pre-exposure to these appetitive stimuli did not prevent the DA response in the NAc These results show that the phasic responsiveness of NAc DA transmission to an unfamiliar palatable food is under strong modulatory control by primary (consummatory) and secondary (appetitive) stimuli, and that the sign and extent of this control depends on the nature of the appetitive stimulus, delay of reward and motivational state (deprivation)