Showing papers by "University of California published in 2005"

Water sanitation and hygiene interventions to reduce diarrhoea in less developed countries: a systematic review and meta-analysis.

Abstract: Many studies have reported the results of interventions to reduce illness through improvements in drinking water, sanitation facilities, and hygiene practices in less developed countries. There has, however, been no formal systematic review and meta-analysis comparing the evidence of the relative effectiveness of these interventions. We developed a comprehensive search strategy designed to identify all peer-reviewed articles, in any language, that presented water, sanitation, or hygiene interventions. We examined only those articles with specific measurement of diarrhoea morbidity as a health outcome in non-outbreak conditions. We screened the titles and, where necessary, the abstracts of 2120 publications. 46 studies were judged to contain relevant evidence and were reviewed in detail. Data were extracted from these studies and pooled by meta-analysis to provide summary estimates of the effectiveness of each type of intervention. All of the interventions studied were found to reduce significantly the risks of diarrhoeal illness. Most of the interventions had a similar degree of impact on diarrhoeal illness, with the relative risk estimates from the overall meta-analyses ranging between 0·63 and 0·75. The results generally agree with those from previous reviews, but water quality interventions (point-of-use water treatment) were found to be more effective than previously thought, and multiple interventions (consisting of combined water, sanitation, and hygiene measures) were not more effective than interventions with a single focus. There is some evidence of publication bias in the findings from the hygiene and water treatment interventions.

Standards for ecologically successful river restoration

Abstract: Summary 1. Increasingly, river managers are turning from hard engineering solutions to ecologically based restoration activities in order to improve degraded waterways. River restoration projects aim to maintain or increase ecosystem goods and services while protecting downstream and coastal ecosystems. There is growing interest in applying river restoration techniques to solve environmental problems, yet little agreement exists on what constitutes a successful river restoration effort. 2. We propose five criteria for measuring success, with emphasis on an ecological perspective. First, the design of an ecological river restoration project should be based on a specified guiding image of a more dynamic, healthy river that could exist at the site. Secondly, the river’s ecological condition must be measurably improved. Thirdly, the river system must be more self-sustaining and resilient to external perturbations so that only minimal follow-up maintenance is needed. Fourthly, during the construction phase, no lasting harm should be inflicted on the ecosystem. Fifthly, both pre- and postassessment must be completed and data made publicly available. 3. Determining if these five criteria have been met for a particular project requires development of an assessment protocol. We suggest standards of evaluation for each of the five criteria and provide examples of suitable indicators. 4. Synthesis and applications . Billions of dollars are currently spent restoring streams and rivers, yet to date there are no agreed upon standards for what constitutes ecologically beneficial stream and river restoration. We propose five criteria that must be met for a river restoration project to be considered ecologically successful. It is critical that the broad restoration community, including funding agencies, practitioners and citizen restoration groups, adopt criteria for defining and assessing ecological success in restoration. Standards are needed because progress in the science and practice of river restoration has been hampered by the lack of agreed upon criteria for judging ecological success. Without well-accepted criteria that are ultimately supported by funding and implementing agencies, there is little incentive for practitioners to assess and report restoration outcomes. Improving methods and weighing the ecological benefits of various restoration approaches require organized national-level reporting systems.

Influence of high latitude ice cover on the marine Intertropical Convergence Zone

Abstract: We investigate the causes for a strong high latitude imposed ice (land or sea) influence on the marine Intertropical Convergence Zone (ITCZ) in the Community Climate Model version 3 coupled to a 50-m slab ocean. The marine ITCZ in all the ocean basins shift meridionally away from the hemisphere with an imposed added ice cover, altering the global Hadley circulation with an increased tropical subsidence in the hemisphere with imposed ice and uplift in the other. The effect appears to be independent of the longitudinal position of imposed ice. The anomalous ice induces a rapid cooling and drying of the air and surface over the entire high- and midlatitudes; subsequent progression of cold anomalies occurs in the Pacific and Atlantic northeasterly trade regions, where a wind-evaporation-sea surface temperature (SST) feedback initiates progression of a cold SST ‘front’ towards the ITCZ latitudes. Once the cooler SST reaches the ITCZ latitude, the ITCZ shifts southwards, aided by positive feedbacks associated with the displacement. The ITCZ displacement transports moisture away from the colder and drier hemisphere into the other hemisphere, resulting in a pronounced hemispheric asymmetric response in anomalous specific humidity; we speculate that the atmospheric humidity plays a central role in the hemispheric asymmetric nature of the climate response to high latitude ice cover anomalies. From an energy balance viewpoint, the increased outgoing radiative flux at the latitudes of the imposed ice is compensated by an increased radiative energy flux at the tropical latitudes occupied by the displaced ITCZ, and subsequently transported by the altered Hadley and eddy circulations to the imposed ice latitudes. The situation investigated here may be applicable to past climates like the Last Glacial Maximum where hemispheric asymmetric changes to ice cover occurred. Major caveats to the conclusions drawn include omission of interactive sea ice physics and ocean dynamical feedback and sensitivity to atmospheric physics parameterizations across different models.

Discrete Choice Models in Preference Space and Willingness-to Pay Space

Abstract: In models with unobserved taste heterogeneity, distributional assumptions can be placed in two ways: (1) by specifying the distribution of coefficients in the utility function and deriving the distribution of willingness to pay (WTP), or (2) by specifying the distribution of WTP and deriving the distribution of coefficients. In general the two approaches are equivalent, in that any mutually compatible distributions for coefficients and WTP can be represented in either way. However, in practice, convenient distributions, such as normal or log-normal, are usually specified, and these convenient distributions have different implications when placed on WTP’s than on coefficients. We compare models that use normal and log-normal distributions for coefficients (called models in preference space) with models using these distributions for WTP (called models in WTP space). We find that the models in preference space fit the data better but provide less reasonable distributions of WTP than the models in WTP space. Our findings suggests that further work is needed to identify distributions that either fit better when applied in WTP space or imply more reasonable distributions of WTP when applied in preference space.

DAMPED LYα SYSTEMS

Abstract: ▪ Abstract Observations of damped Lyα systems offer a unique window on the neutral-gas reservoirs that gave rise to galaxies at high redshifts. This review focuses on critical properties such as the H I and metal content of the gas and on independent evidence for star formation. Together, these provide an emerging picture of gravitationally bound objects in which accretion of gas from the IGM replenishes gas consumed by star formation. Other properties such as dust content, molecular content, ionized-gas content, gas kinematics, and galaxy identifications are also reviewed. These properties point to a multiphase ISM in which radiative and hydrodynamic feedback processes are present. Numerical simulations and other types of models used to describe damped Lyα systems within the context of galaxy formation are also discussed.

Wavelength-division-multiplexed passive optical network (WDM-PON) technologies for broadband access: a review (Invited)

Abstract: Feature Issue on Optical Access Networks (OAN) The passive optical network (PON) is an optical fiber based network architecture, which can provide much higher bandwidth in the access network compared to traditional copper-based networks. Incorporating wavelength-division multiplexing (WDM) in a PON allows one to support much higher bandwidth compared to the standard PON, which operates in the "single-wavelength mode" where one wavelength is used for upstream transmission and a separate one is used for downstream transmission. We present a comprehensive review of various aspects of WDM-PONs proposed in the literature. This includes enabling device technologies for WDM-PONs and network architectures, as well as the corresponding protocols and services that may be deployed on a WDM-PON. The WDM-PON will become a revolutionary and scalable broadband access technology that will provide high bandwidth to end users.

Looking for Locals: Voter Information Demands and Personal Vote‐Earning Attributes of Legislators under Proportional Representation

Abstract: Proportional representation systems affect the extent to which elected legislators exhibit various attributes that allow them to earn a personal vote. The sources of variation in personal vote-earning attributes (PVEA) lie in informational shortcuts voters use under different electoral rules. List type (closed or open) and district magnitude (the number of legislators elected from a district) affect the types of shortcuts voters employ. When lists are closed, legislators' PVEA are of decreasing usefulness to voters as magnitude (and hence the number of candidates on a list) increases. When lists are open, legislators' PVEA are increasingly useful to voters as magnitude increases, because the number of candidates from which voters must choose whom to give a preference vote increases. As predicted by the theory, the probability that a legislator will exhibit PVEA—operationalized as local birthplace or lower-level electoral experience—declines with magnitude when lists are closed, but rises with magnitude when lists are open.

Incentives to learn

Abstract: This brief summarizes the results of a gender impact evaluation study, entitled Incentives to learn, conducted between March 2001 and March 2002 school year in Kenya. The study observed the impact of merit scholarship program on adolescent girls in Kenya on the student level. Girls who were eligible for the scholarships had significantly higher test scores than comparison schoolgirls. The effect size was about 0.2 to 0.3 standard deviations. Teacher attendance also improved significantly in program schools. There were positive externalities on girls who started off with low baseline scores who had little chance of receiving the scholarship. There is evidence that the scholarship program did not reduce intrinsic motivation. Funding for the study derived from the World Bank and the MacArthur Foundation.

Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study

Abstract: We investigated whether low subcutaneous thigh fat is an independent risk factor for unfavourable glucose and lipid levels, and whether these associations differ between sexes, and between white and black adults. Our secondary aim was to investigate which body composition characteristics (lean tissue, fat tissue) are reflected by anthropometric measures (waist and thigh circumference). Anthropometric measurements and computed tomography of the abdomen and of the thigh were performed for all participants of the Health, Aging and Body Composition Study, who were aged 70–79 years. Fasting glucose, triglycerides and HDL-cholesterol, and 2-h postload glucose were determined. After excluding those already diagnosed with diabetes or dyslipidaemia, we analysed data from 2,106 participants. After adjustment for abdominal subcutaneous and visceral fat, and intermuscular thigh fat, larger thigh subcutaneous fat area was statistically significantly associated with lower ln-transformed triglycerides [standardised beta (95% CI) −0.12 (−0.20 to −0.04) in men and −0.13 (−0.21 to −0.05) in women] and higher ln-HDL-cholesterol [0.10 (0.02 to 0.19) and 0.09 (0.01 to 0.18), respectively]. The associations with lower glucose levels were strong in men [−0.11 (−0.20 to −0.02) for fasting and −0.14 (−0.23 to −0.05) for postload glucose], but not statistically significant in women [−0.02 (−0.10 to 0.07) and −0.04 (−0.13 to 0.05), respectively]. There were no differences in the associations between white and black persons. Waist circumference was more strongly associated with abdominal subcutaneous fat, and this association became stronger with increasing BMI, whereas the association with visceral fat became weaker. Thigh circumference was equally dependent on thigh fat and thigh muscle in men, whereas in women the fat component was the main contributor. Larger subcutaneous thigh fat is independently associated with more favourable glucose (in men) and lipid levels (in both sexes) after accounting for abdominal fat depots, which are associated with unfavourable glucose and lipid levels. Anthropometric measures reflect different fat depots at different levels of BMI at the abdomen, and reflect both fat and lean tissue at the thigh. These results emphasise the importance of accurate measures of regional body composition when investigating potential health risks.

Wetting morphologies at microstructured surfaces

Abstract: The wetting of microstructured surfaces is studied both experimentally and theoretically. Even relatively simple surface topographies such as grooves with rectangular cross section exhibit a large variety of different wetting morphologies as observed by atomic force microscopy. This polymorphism arises from liquid wedge formation along the groove corners and from contact line pinning along the groove edges. A global morphology diagram is derived that depends only on two system parameters: (i) the aspect ratio of the groove geometry and (ii) The contact angle of the underlying substrate material. For microfluidics, the most interesting shape regimes involve extended liquid filaments, which can grow and shrink in length while their cross section stays essentially constant. Thus, any method by which one can vary the contact angle can be used to switch the length of the filament, as is demonstrated in the context of electrowetting.

Hydraulic redistribution in three Amazonian trees

Abstract: About half of the Amazon rainforest is subject to seasonal droughts of 3 months or more. Despite this drought, several studies have shown that these forests, under a strongly seasonal climate, do not exhibit significant water stress during the dry season. In addition to deep soil water uptake, another contributing explanation for the absence of plant water stress during drought is the process of hydraulic redistribution; the nocturnal transfer of water by roots from moist to dry regions of the soil profile. Here, we present data on patterns of soil moisture and sap flow in roots of three dimorphic-rooted species in the Tapajos Forest, Amazonia, which demonstrate both upward (hydraulic lift) and downward hydraulic redistribution. We measured sap flow in lateral and tap roots of our three study species over a 2-year period using the heat ratio method, a sap-flow technique that allows bi-directional measurement of water flow. On certain nights during the dry season, reverse or acropetal flow (i.e.,in the direction of the soil) in the lateral roots and positive or basipetal sap flow (toward the plant) in the tap roots of Coussarea racemosa (caferana), Manilkara huberi (macaranduba) and Protium robustum (breu) were observed, a pattern consistent with upward hydraulic redistribution (hydraulic lift). With the onset of heavy rains, this pattern reversed, with continuous night-time acropetal sap flow in the tap root and basipetal sap flow in lateral roots, indicating water movement from wet top soil to dry deeper soils (downward hydraulic redistribution). Both patterns were present in trees within a rainfall exclusion plot (Seca Floresta) and to a more limited extent in the control plot. Although hydraulic redistribution has traditionally been associated with arid or strongly seasonal environments, our findings now suggest that it is important in ameliorating water stress and improving rain infiltration in Amazonian rainforests. This has broad implications for understanding and modeling ecosystem process and forest function in this important biome.

Biological sensitivity to context: II. Empirical explorations of an evolutionary–developmental theory

Abstract: In two studies comprising 249 children and their families, the authors utilized secondary, exploratory data analyses to examine Boyce and Ellis’ ~this issue! evolutionary‐developmental theory of biological sensitivity to context. The theory proposes that individual differences in stress reactivity constitute variation in susceptibility to environmental influence, both positive and negative, and that early childhood exposures to either highly protective or acutely stressful environments result in heightened reactivity. In Study 1, 127 3- to 5-year old children were concurrently assessed on levels of support0adversity in home and preschool environments and on cardiovascular reactivity to laboratory challenges. In Study 2, 122 children were prospectively assessed on familial stress in both infancy and preschool and on autonomic and adrenocortical reactivity to laboratory challenges at age 7. In both studies, a disproportionate number of children in supportive, low stress environments displayed high autonomic reactivity. Conversely, in Study 2, a relatively high proportion of children in very stressful environments showed evidence of heightened sympathetic and adrenocortical reactivity. Consistent with the evolutionary‐developmental theory, the exploratory analyses also generated the testable hypothesis that relations between levels of childhood support0adversity and the magnitude of stress reactivity are curvilinear, with children from moderately stressful environments displaying the lowest reactivity levels in both studies.

Grammatical Gender and Number Agreement in Spanish: An ERP Comparison

Abstract: The role of grammatical gender and number representations in syntactic processes during reading in Spanish was studied using the event-related potentials (ERPs) technique. The electroencephalogram was recorded with a dense array of 128 electrodes while Spanish speakers read word pairs (Experiment 1) or sentences (Experiment 2) in which gender or number agreement relationships were manipulated. Disagreement in word pairs formed by a noun and an adjective (e.g., faro–alto [lighthouse–high]) produced an N400-type effect, while word pairs formed by an article and a noun (e.g., el–piano [ the-piano]) showed an additional left anterior negativity effect (LAN). Agreement violations with the same words inserted in sentences (e.g., El piano estaba viejo y desafinado [them-spiano m-swas old m-sand off-key]) resulted in a pattern of LAN–P600. This effect was found both when the violation occurred in the middle of the sentence (at the adjective), as well as when this happened at the beginning of the sentence (at the noun), but the last segment of the P600 effect was greater for the middle sentence position, which could indicate differences in the complexity of reanalysis processes. Differences between grammatical gender and number disagreement were found in late measures. In the word pairs experiment, P3 peak latency varied across conditions, being later for gender than for number disagreement. Similarly, in the sentence experiment, the last segment of the P600 effect was greater for gender than for number violations. These event-related potentials (ERPs) effects lend support to the idea that reanalysis or repair processes after grammatical disagreement detection could involve more steps in the case of gender disagreement, as grammatical gender is a feature of the lexical representation in contrast to number, which is considered a morphological feature that combines with the stem of the word.

Explaining Corporate Environmental Performance: How Does Regulation Matter?

Abstract: Explaining Corporate Environmental Performance: How Does Regulation Matter? Robert A. Kagan Dorothy Thornton Neil Gunningham How and to what extent does regulation matter in shaping corporate behavior? How important is it compared to other incentives and mechanisms of social control, and how does it interact with those mechanisms? How might we explain variation in corporate responses to law and other external pressures? This article addresses these questions through an study of environmental performance in 14 pulp and paper manufacturing mills in Australia, New Zealand, British Columbia, and the states of Washington and Georgia in the United States. Over the last three decades, we find tightening regulatory requirements and intensifying political pressures have brought about large improvements and considerable convergence in environmental performance by pulp manufacturers, most of which have gone ‘‘beyond compliance’’ in several ways. But regulation does not account for remaining differences in environmental performance across facilities. Rather, ‘‘social license’’ pressures (particularly from local communities and environmental activists) and corporate environmental management style prod some firms toward better performance compliance than others. At the same time, economic pressures impose limits on ‘‘beyond performance’’ investments. In producing large gains in environmental performance, however, regulation still matters greatly, but less as a system of hierarchically imposed, uniformly enforced rules than as a coordinative mechanism, routinely interacting with market pressures, local and national environmental activists, and the culture of corporate management in generating environmental improvement while narrowing the spread between corporate leaders and laggards. I. Introduction I n what ways and to what extent does regulation matter in shaping corporate behavior? How important is it compared to The authors are grateful to scores of pulp mill managers, regulatory officials, industry consultants, and environmental activistsFall of whom must remain anonymousFfor their cooperation and insight. David Sonnenfeld, Kathryn Harrison, Peter May, and anonymous reviewers all gave us valuable advice on earlier drafts. Biyi Abesina provided valuable research assistance. The Center for the Study of Law and Society, University of California, Berkeley, provided space, administrative assistance, and social support for the research project that led to this article, and the Smith Richardson Foundation funded our research. Please direct correspondence to Robert A. Kagan, Center for the Study of Law & Society, University of California, 2240 Piedmont Ave., Berkeley, CA 94720; tel: (510) 642-4038; email: rak@uclink4.berkeley.edu. Law & Society Review, Volume 37, Number 1 (2003) r 2003 by The Law and Society Association. All rights reserved.

A Meta‐Analysis of the Effect of Common Currencies on International Trade*

Abstract: . Thirty-four recent studies have investigated the effect of currency union on trade, resulting in 754 point estimates of this effect. This paper uses meta-analysis to combine, explain, and to summarize these disparate estimates of common currency trade effects. The hypothesis that there is no effect of currency union on trade is easily and robustly rejected at standard significance levels. Combining these estimates implies that a currency union increases bilateral trade by between 30 and 90%. Although there is evidence of publication selection, there is also evidence of a genuine positive trade effect beyond publication bias.

Mixed Logit with Bounded Distributions of Correlated Partworths

Abstract: The use of a joint normal distribution for partworths is computationally attractive, particularly with Bayesian MCMC procedures, and yet is unrealistic for any attribute whose partworth is logically bounded (e.g., is necessarily positive or cannot be unboundedly large). A mixed logit is specified with partworths that are transformations of normally distributed terms, where the transformation induces bounds; examples include censored normals, log-normals, and S B distributions which are bounded on both sides. The model retains the computational advantages of joint normals while providing greater flexibility for the distributions of correlated partworths. The method is applied to data on customers’ choice among vehicles in stated choice experiments. The flexibility that the transformations allow is found to greatly improve the model, both in terms of fit and plausibility, without appreciably increasing the computational burden.

Khovanov-Rozansky homology and topological strings

Abstract: We conjecture a relation between the sl(N) knot homology, recently introduced by Khovanov and Rozansky, and the spectrum of BPS states captured by open topological strings. This conjecture leads to new regularities among the sl(N) knot homology groups and suggests that they can be interpreted directly in topological string theory. We use this approach in various examples to predict the sl(N) knot homology groups for all values of N. We verify that our predictions pass some non-trivial checks.

The role of predation in the decline and extirpation of woodland caribou

Abstract: To select appropriate recovery strategies for endangered populations, we must understand the dynamics of small populations and distinguish between the possible causes that drive such populations to low numbers. It has been suggested that the pattern of population decline may be inversely density-dependent with population growth rates decreasing as populations become very small; however, empirical evidence of such accelerated declines at low densities is rare. Here we analyzed the pattern of decline of a threatened population of woodland caribou (Rangifer tarandus caribou) in British Columbia, Canada. Using information on the instantaneous rate of increase relative to caribou density in suitable winter foraging habitat, as well as on pregnancy rates and on causes and temporal distribution of mortalities from a sample of 349 radiocollared animals from 15 subpopulations, we tested 3 hypothesized causes of decline: (a) food regulation caused by loss of suitable winter foraging habitat, (b) predation-sensitive foraging caused by loss of suitable winter foraging habitat and (c) predation with caribou being secondary prey. Population sizes of caribou subpopulations ranged from 500 individuals. Our results showed that the rates of increase of these subpopulations varied from −0.1871 to 0.0496 with smaller subpopulations declining faster than larger subpopulations. Rates of increase were positively related to the density of caribou in suitable winter foraging habitat. Pregnancy rates averaged 92.4% ±2.24 and did not differ among subpopulations. In addition, we found predation to be the primary cause of mortality in 11 of 13 subpopulations with known causes of mortality and predation predominantly occurred during summer. These results are consistent with predictions that caribou subpopulations are declining as a consequence of increased predation. Recovery of these woodland caribou will thus require a multispecies perspective and an appreciation for the influence of inverse density dependence on population trajectories.

Precopulatory sexual cannibalism in fishing spiders (Dolomedes triton): a role for behavioral syndromes

Abstract: Precopulatory sexual cannibalism (predation of a potential mate prior to copulation) offers an extreme example of intersexual conflict, a current focus in behavioral ecology. The ‘aggressive-spillover’ hypothesis, posits that precopulatory sexual cannibalism may be a nonadaptive by-product of a general syndrome of voracity (aggression towards prey) that is expressed in multiple behavioral contexts. In this view, selection favoring high levels of voracity throughout ontogeny spills over to cause sexual cannibalism in adult females even when it is not necessarily beneficial. Using the North American fishing spider, Dolomedes triton, we present the first in depth test of this hypothesis. We found support for three aspects of the spillover hypothesis. First, voracity towards hetero-specific prey results in high feeding rates, large adult size, and increased fecundity. Second, juvenile and adult voracity are positively correlated (i.e., voracity is a consistent trait over ontogeny). Third, voracity towards hetero-specific prey is indeed positively correlated with precopulatory sexual cannibalism. Assays of antipredator behavior further revealed positive correlations between boldness towards predators, voracity and precopulatory sexual cannibalism. Overall, our results support the notion that precopulatory sexual cannibalism in D. triton is part of a behavioral syndrome spanning at least three major contexts: foraging, predator avoidance, and mating.

Combustion theory and modeling

Abstract: In honor of the fiftieth anniversary of the Combustion Institute, we are asked to assess accomplishments of theory in combustion over the past fifty years and prospects for the future. The title of our article is chosen to emphasize that development of theory necessarily goes hand-in-hand with specification of a model. Good conceptual models underlie successful mathematical theories. Models and theories are discussed here for deflagrations, detonations, diffusion flames, ignition, propellant combustion, and turbulent combustion. In many of these areas, the genesis of mathematical theories occurred during the past fifty years, and in all of them significant advances are anticipated in the future. Increasing interaction between theory and computation will aid this progress. We hope that, although certainly not complete in topical coverage or reference citation, the presentation may suggest useful directions for future research in combustion theory.

Factors associated with the lumbar spine and proximal femur bone mineral density in older men

Abstract: Bone mass is a major determinant of fracture, but there have been few comprehensive studies of the correlates of bone mineral density (BMD) in older men. The objective of the current cross-sectional analysis was to determine the factors associated with BMD of the lumbar spine and proximal femur in a large population-based sample of older men enrolled in The Osteoporotic Fractures in Men Study, "Mr.OS." We enrolled 5,995 men 65 years of age or older, 89% Caucasian, in Mr.OS at six US clinical centers. Demographic, medical and family history and lifestyle information was obtained by interview and physical function and anthropometric data by examination. Spine and hip BMD was measured using dual-energy X-ray absorptimetry. The multivariable linear regression models predicted 19 and 10% of the overall variance in BMD of the femoral neck and spine, respectively. African-American men had 6 to 11% higher BMD than Caucasian men independent of multiple factors. Hip BMD declined with advancing age, while spine BMD increased. Body weight (per 10 kg) and self report of diabetes were each associated with 2 to 4% higher BMD, while history of a non-trauma fracture and current use of selective serotonin reuptake inhibitors, but not other antidepressants, were associated with at least 4% lower BMD. Both maternal and paternal histories of fracture were associated with 1.4-1.7% lower BMD. Osteoarthritis, physical activity, grip strength, alcohol intake, and dietary calcium were positively related to BMD, while a history of chronic lung disease, prostate cancer, and kidney stones was associated with lower BMD. Smoking, caffeine intake, and thiazide diuretics were not related to BMD in older men. A number of lifestyle and behavioral characteristics and medical conditions were associated with BMD in older men. Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology.

Leafy cotyledon genes are essential for induction of somatic embryogenesis of Arabidopsis

Abstract: The capacity for somatic embryogenesis was studied in lec1, lec2 and fus3 mutants of Arabidopsis thaliana (L.) Heynh. It was found that contrary to the response of wild-type cultures, which produced somatic embryos via an efficient, direct process (65-94% of responding explants), lec mutants were strongly impaired in their embryogenic response. Cultures of the mutants formed somatic embryos at a low frequency, ranging from 0.0 to 3.9%. Moreover, somatic embryos were formed from callus tissue through an indirect route in the lec mutants. Total repression of embryogenic potential was observed in double (lec1 lec2, lec1 fus3, lec2 fus3) and triple (fus3 lec1 lec2) mutants. Additionally, mutants were found to exhibit efficient shoot regenerability via organogenesis from root explants. These results provide evidence that, besides their key role in controlling many different aspects of Arabidopsis zygotic embryogenesis, LEC/FUS genes are also essential for in vitro somatic embryogenesis induction. Furthermore, temporal and spatial patterns of auxin distribution during somatic embryogenesis induction were analyzed using transgenic Arabidopsis plants expressing GUS driven by the DR5 promoter. Analysis of data indicated auxin accumulation was rapid in all tissues of the explants of both wild type and the lec2-1 mutant, cultured on somatic embryogenesis induction medium containing 2,4-D. This observation suggests that loss of embryogenic potential in the lec2 mutant in vitro is not related to the distribution of exogenously applied auxin and LEC genes likely function downstream in auxin-induced somatic embryogenesis.

Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria

Abstract: Background Riboswitches are RNA elements in the 5' untranslated leaders of bacterial mRNAs that directly sense the levels of specific metabolites with a structurally conserved aptamer domain to regulate expression of downstream genes. Riboswitches are most common in the genomes of low GC Gram-positive bacteria (for example, Bacillus subtilis contains examples of all known riboswitches), and some riboswitch classes seem to be restricted to this group.

Lectures on the Langlands program and conformal field theory

Abstract: These lecture notes give an overview of recent results in geometric Langlands correspondence which may yield applications to quantum field theory. We start with a motivated introduction to the Langlands Program, including its geometric reformulation, addressed primarily to physicists. I tried to make it as self-contained as possible, requiring very little mathematical background. Next, we describe the connections between the Langlands Program and two-dimensional conformal field theory that have been found in the last few years. These connections give us important insights into the physical implications of the Langlands duality.

Naloxone distribution and cardiopulmonary resuscitation training for injection drug users to prevent heroin overdose death: A pilot intervention study

Abstract: Fatal heroin overdose has become a leading cause of death among injection drug users (IDUs). Several recent feasibility studies have concluded that naloxone distribution programs for heroin injectors should be implemented to decrease heroin overdose deaths, but there have been no prospective trials of such programs in North America. This pilot study was undertaken to investigate the safety and feasibility of training injection drug using partners to perform cardiopulmonary resuscitation (CPR) and administer naloxone in the event of heroin overdose. During May and June 2001, 24 IDUs (12 pairs of injection partners) were recruited from street settings in San Francisco. Participants took part in 8-hour training in heroin overdose prevention, CPR, and the use of naloxone. Following the intervention, participants were prospectively followed for 6 months to determine the number and outcomes of witnessed heroin overdoses, outcomes of participant interventions, and changes in participants’ knowledge of overdose and drug use behavior. Study participants witnessed 20 heroin overdose events during 6 months follow-up. They performed CPR in 16 (80%) events, administered naloxone in 15 (75%) and did one or the other in 19 (95%). All overdose victims survived. Knowledge about heroin overdose management increased, whereas heroin use decreased. IDUs can be trained to respond to heroin overdose emergencies by performing CPR and administering naloxone. Future research is needed to evaluate the effectiveness of this peer intervention to prevent fatal heroin overdose.

Geographical gradients of marine herbivorous fishes: patterns and processes

Abstract: We present new data and the first rigorous analysis of latitudinal and thermal gradients of diversity, density and biomass of marine herbivorous fishes and review proposed explanatory mechanisms. Consistently, negative relationships between latitude, and positive relationships between sea surface temperature (SST), and relative richness and relative abundance of herbivorous fishes were found worldwide. Significant differences in the strength of gradients of richness and abundance with latitude and SST between tropical and extratropical zones were found consistently across ocean basins. Standardized sampling along the western Atlantic also showed negative relationships between latitude and total density and biomass. The trends, however, are driven by different components of the fish assemblages (i.e., scarids in the Caribbean and acanthurids in Brazil). Patterns of abundance along thermal gradients, generally associated with extensive latitudinal gradients, also were found at the local scale. Feeding rate of the ocean surgeonfish Acanthurus bahianus decreases with temperature more rapidly than the mean metabolic rate of teleost fishes. This relationship suggests a temperature-related physiological constraint. From the new standardized and comparative data presented and the review of the explanatory hypotheses, we conclude that temperature-related feeding and digestive processes are most likely involved in the distribution patterns of herbivorous fishes.

Flash welding of conducting polymer nanofibers

Abstract: The welding of certain polymeric nanofibers can be accomplished by exposure to an intense short burst of light, such as is provided by a camera flash, resulting in an instantaneous melting of the exposed fibers and a welding of the fibers where they are in contact. The preferred nanofibers are composed of conjugated, conducting polymers, and derivatives and polymer blends including such materials. Alternatively, the nanofibers can be composed of colored thermoplastic polymeric fibers or opaque polymers by proper selection of the frequency or frequency range and intensity (power) of the light source. The flash welding process can also be used to weld nanofibers which comprise a blend of polymeric materials where at least one of the materials in the blend used to form the nanofiber is a conductive, conjugated polymer or a suitable colored thermoplastic. Alternatively the material blend used to form the nanofibers may comprise a polymeric material containing a colored additive, which is not necessarily a polymer, for example carbon black, or a colored nano-particulate organic or inorganic material, dye or pigment.