University of California

About: University of California is a education organization based out in Oakland, California, United States. It is known for research contribution in the topics: Population & Layer (electronics). The organization has 55175 authors who have published 52933 publications receiving 1491169 citations. The organization is also known as: UC & University of California System.

Remarks on Some Nonparametric Estimates of a Density Function

Abstract: This note discusses some aspects of the estimation of the density function of a univariate probability distribution. All estimates of the density function satisfying relatively mild conditions are shown to be biased. The asymptotic mean square error of a particular class of estimates is evaluated.

Body concerns in and out of the bedroom: implications for sexual pleasure and problems.

Abstract: Objectification theory (Fredrickson B. L., & Roberts, T. A. (1997). Psychology of Women Quarterly, 21, 173-206) proposes that body image concerns impair sexual function and satisfaction. The present study was designed to test whether body shame was related to sexual problems and pleasure among heterosexual men and women (N = 320). Using structural equation modeling, we tested whether adult men and women's body shame was linked to greater sexual problems (lower sexual arousability and ability to reach orgasm) and less pleasure from physical intimacy. Although women were significantly more likely to report appearance concerns than men across sexual and non-sexual contexts, appearance concerns were positively related to both men and women's sexual problems. The relationship between body shame and sexual pleasure and problems was mediated by sexual self-consciousness during physical intimacy. Men and women's body shame was related to greater sexual self-consciousness, which in turn predicted lower sexual pleasure and sexual arousability. Results persisted controlling for relationship status and age. Being in a relationship was associated with less sexual self-consciousness and less orgasm difficulty for men and women. Although some paths were significantly stronger for women than for men, results largely supported the proposition that body concerns negatively affect sexual pleasure and promote sexual problems for both men and women. Findings were discussed in terms of objectification theory and the increased cultural emphasis on physical appearance.

Molecular Techniques to Assess Microbial Community Structure, Function, and Dynamics in the Environment

Abstract: Culture-based methods are important in investigating the microbial ecology of natural and anthropogenically impacted environments, but they are extremely biased in their evaluation of microbial genetic diversity by selecting a particular population of microorganisms. With recent advances in genomics and sequencing technologies, microbial community analyses using culture-independent molecular techniques have initiated a new era of microbial ecology. Molecular analyses of environmental communities have revealed that the cultivable fraction represents <1% of the total number of prokaryotic species present in any given sample. A variety of molecular methods based on direct isolation and analysis of nucleic acids, proteins, and lipids from environmental samples have been discovered and revealed structural and functional information about microbial communities. Molecular approaches such as genetic fingerprinting, metagenomics, metaproteomics, metatranscriptomics, and proteogenomics are vital for discovering and characterizing the vast microbial diversity and understanding their interactions with biotic and abiotic environmental factors. This chapter summarizes recent progress in the area of molecular microbial ecology with an emphasis on novel techniques and approaches that offer new insights into the phylogenetic and functional diversity of microbial assemblages. The advantages and pitfalls of commonly used molecular methods to investigate microbial communities are discussed. The potential applications of each molecular technique and how they can be combined for a greater comprehensive assessment of microbial diversity has been illustrated with example studies.

The Effect of Treatment on Mortality in Mild Hypertension: Results of the Hypertension Detection and Follow-up Program

Abstract: In the Hypertension Detection and Follow-up Program, 7825 (71.5 per cent) of the 10,940 participants had diastolic blood pressures averaging between 90 and 104 mm Hg on entry into the study and were designated Stratum 1. Half were referred to their usual source of care in the community (the referred-care group), and half were treated intensively in special clinics (the stepped-care group). Five-year mortality in the Stratum 1 patients given stepped care was 20.3 per cent lower than in those given referred care (P less than 0.01). Particularly noteworthy was the beneficial effect of stepped-care treatment on persons with diastolic pressures of 90 to 104 mm Hg who had no evidence of end-organ damage and were not receiving antihypertensive medication when they entered the study. This subgroup had 28.6 per cent fewer deaths at five years among those treated with stepped care than among those treated with referred care (P less than 0.01). These findings support a recommendation that in patients with mild hypertension, treatment should be considered early, before damage to end organs occurs.