University of California

About: University of California is a education organization based out in Oakland, California, United States. It is known for research contribution in the topics: Population & Layer (electronics). The organization has 55175 authors who have published 52933 publications receiving 1491169 citations. The organization is also known as: UC & University of California System.

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

Abstract: Bile acids and bile alcohols in the form of their conjugates are amphipathic end products of cholesterol metabolism with multiple physiological functions. The great variety of bile acids and bile alcohols that are present in vertebrates are tabulated. Bile salts have an enterohepatic circulation resulting from efficient vectorial transport of bile salts through the hepatocyte and the ileal enterocyte; such transport leads to the accumulation of a pool of bile salts that cycles between the liver and intestine. Bile salt anions promote lipid absorption, enhance tryptic cleavage of dietary proteins, and have antimicrobial effects. Bile salts are signaling molecules, activating nuclear receptors in the hepatocyte and ileal enterocyte, as well as an increasing number of G-protein coupled receptors. Bile acids are used therapeutically to correct deficiency states, to decrease the cholesterol saturation of bile, or to decrease the cytotoxicity of retained bile acids in cholestatic liver disease.

Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Abstract: A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.

Family-Peer Relationships: Modes of Linkage.

Abstract: This volume provides an up-to-date overview of recent research concerning the links between family and peer systems. Considerable work in the past has focused on family issues or peer relationships, but these systems have typically been considered separately. This volume bridges the gap across these two important socialization contexts and provides insights into the processes that account for the links across the systems -- the ways in which the relationships between these systems shift across development. In addition, the variations in the links between family and peers are illustrated by cross-cultural work, studies of abused children, and research on the impact of maternal depression. In short, the volume provides not only a convenient overview of recent progress but lays out an agenda for future research.

The Theory of Shells and Plates

Abstract: A plate and more generally a shell is a special three-dimensional body whose boundary surface has special features. Although we defer defining a shell-like body in precise terms until Sect. 4, for the purpose of these preliminary remarks consider a surface—called a reference surface—and imagine material filaments from above and below surrounding the surface along the normal at each point of the reference surface. Suppose further that the bounding surfaces formed by the end points of the material filaments are equidistant from the reference surface. Such a three-dimensional body is called a shell if the dimension of the body along the normals, called the thickness, is small. A shell is said to be thin if its thickness is much smaller than a certain characteristic length of the reference surface, e.g., the minimum radius of the curvature of the reference surface for initially curved shells.2

Chapter 13 Wald, likelihood ratio, and Lagrange multiplier tests in econometrics

Abstract: Publisher Summary The use of increasingly complex statistical models has led to heavy reliance on maximum likelihood methods for both estimation and testing. In such a setting, only asymptotic properties can be expected for estimators or tests. Often there are asymptotically equivalent procedures that differ substantially in computational difficulty and finite sample performance. In a maximum likelihood framework, the Wald, Likelihood Ratio, and Lagrange Multiplier (LM) tests are a natural trio. They all share the property of being asymptotically locally the most powerful invariant tests, and in fact all are asymptotically equivalent. However, in practice, there are substantial differences in the way the tests look at particular models. Frequently when one is very complex, another will be much simpler. Furthermore, this formulation guides the intuition as to what is testable and how best to formulate a model to test it. In terms of forming diagnostic tests, the LM test is frequently computationally convenient as many of the test statistics are already available from the estimation of the null. The application of these tests principles and particularly the LM principle to a wide range of econometric problems is a natural development of the field, and it is a development that is proceeding at a very rapid pace.