University of California

About: University of California is a education organization based out in Oakland, California, United States. It is known for research contribution in the topics: Population & Layer (electronics). The organization has 55175 authors who have published 52933 publications receiving 1491169 citations. The organization is also known as: UC & University of California System.

Hydrodynamic and Acoustic Field Detection

Abstract: Fishes have an impressive complement of hydrodynamic and acoustic sensors, commonly referred to as the lateral-line and inner-ear sense organs The basic receptor elements are the hair cells, which detect the minute displacements imparted to their apical ciliary bundles (Fig 41a) The directional sensitivity of the individual receptor cells is indicated by the asymmetric position of the single kinocilium relative to the several rows of stereocilia Morphologically, the hair cells of the various sensory clusters are strikingly uniform Their diversity in function is determined mainly by the peripheral structures coupling the ciliary bundles to the physical world that the animals inhabit

Bevacizumab Added to Neoadjuvant Chemotherapy for Breast Cancer

Abstract: A B S T R AC T BACKGROUND Bevacizumab and the antimetabolites capecitabine and gemcitabine have been shown to improve outcomes when added to taxanes in patients with metastatic breast cancer. The primary aims of this trial were to determine whether the addition of capecitabine or gemcitabine to neoadjuvant chemotherapy with docetaxel, followed by doxorubicin plus cyclophosphamide, would increase the rates of pathological complete response in the breast in women with operable, human epidermal growth factor receptor 2 (HER2)–negative breast cancer and whether adding bevacizumab to these chemotherapy regimens would increase the rates of pathological complete response. METHODS

Incentives to learn

Abstract: This brief summarizes the results of a gender impact evaluation study, entitled Incentives to learn, conducted between March 2001 and March 2002 school year in Kenya. The study observed the impact of merit scholarship program on adolescent girls in Kenya on the student level. Girls who were eligible for the scholarships had significantly higher test scores than comparison schoolgirls. The effect size was about 0.2 to 0.3 standard deviations. Teacher attendance also improved significantly in program schools. There were positive externalities on girls who started off with low baseline scores who had little chance of receiving the scholarship. There is evidence that the scholarship program did not reduce intrinsic motivation. Funding for the study derived from the World Bank and the MacArthur Foundation.

A conceptual model of medical student well-being: promoting resilience and preventing burnout.

Abstract: This article proposes and illustrates a conceptual model of medical student well-being. The authors reviewed the literature on medical student stress, coping, and well-beingand developed a model of medical student coping termed the “coping reservoir.” The reservoir can be replenished or drained by various aspects of medical students’ experiences. The reservoir itself has an internal structure, conceptualized as consisting of the individual’s personal traits temperament and coping style. The coping reservoir metaphor is used to highlight the dynamic nature of students’ experiences, with potential outcomes including enhanced resilience and mental health versus distress and burnout. Medical student well-being is affected by multiple stressors as well as positive aspects of medical training. Attention to individual students’ coping reservoirs can help promote well-being and minimize burnout; formal and informal offerings within medical schools can help fill the reservoir. Helping students cultivate the skills to sustain their well-being throughout their careers has important payoffs for the overall medical education enterprise, for promotion of physician resilience and personal fulfillment, and for enhancement of professionalism and patient care. This and other models of coping should be empirically validated.

Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry.

Abstract: OBJECTIVES: To determine factors associated with COVID-19-related death in people with rheumatic diseases. METHODS: Physician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as covariates in multivariable logistic regression models. Analyses were further stratified according to rheumatic disease category. RESULTS: Of 3729 patients (mean age 57 years, 68% female), 390 (10.5%) died. Independent factors associated with COVID-19-related death were age (66-75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs ≤65 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake). Moderate/high disease activity (vs remission/low disease activity) was associated with higher odds of death (1.87, 1.27 to 2.77). Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. Other synthetic/biological DMARDs were not associated with COVID-19-related death. CONCLUSION: Among people with rheumatic disease, COVID-19-related death was associated with known general factors (older age, male sex and specific comorbidities) and disease-specific factors (disease activity and specific medications). The association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Caution may be required with rituximab, sulfasalazine and some immunosuppressants.