Institution
University of California
Education•Oakland, California, United States•
About: University of California is a education organization based out in Oakland, California, United States. It is known for research contribution in the topics: Population & Layer (electronics). The organization has 55175 authors who have published 52933 publications receiving 1491169 citations. The organization is also known as: UC & University of California System.
Topics: Population, Layer (electronics), Cancer, Context (language use), Gene
Papers published on a yearly basis
Papers
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TL;DR: Water quality interventions (point-of-use water treatment) were found to be more effective than previously thought, and multiple interventions (consisting of combined water, sanitation, and hygiene measures) were not moreeffective than interventions with a single focus.
Abstract: Many studies have reported the results of interventions to reduce illness through improvements in drinking water, sanitation facilities, and hygiene practices in less developed countries. There has, however, been no formal systematic review and meta-analysis comparing the evidence of the relative effectiveness of these interventions. We developed a comprehensive search strategy designed to identify all peer-reviewed articles, in any language, that presented water, sanitation, or hygiene interventions. We examined only those articles with specific measurement of diarrhoea morbidity as a health outcome in non-outbreak conditions. We screened the titles and, where necessary, the abstracts of 2120 publications. 46 studies were judged to contain relevant evidence and were reviewed in detail. Data were extracted from these studies and pooled by meta-analysis to provide summary estimates of the effectiveness of each type of intervention. All of the interventions studied were found to reduce significantly the risks of diarrhoeal illness. Most of the interventions had a similar degree of impact on diarrhoeal illness, with the relative risk estimates from the overall meta-analyses ranging between 0·63 and 0·75. The results generally agree with those from previous reviews, but water quality interventions (point-of-use water treatment) were found to be more effective than previously thought, and multiple interventions (consisting of combined water, sanitation, and hygiene measures) were not more effective than interventions with a single focus. There is some evidence of publication bias in the findings from the hygiene and water treatment interventions.
1,638 citations
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Duke University1, University of Texas at Austin2, Heidelberg Institute for Theoretical Studies3, Xi'an Jiaotong University4, American Museum of Natural History5, Beijing Genomics Institute6, New Mexico State University7, University of Sydney8, University of California9, Uppsala University10, University of Copenhagen11, Okinawa Institute of Science and Technology12, University of Georgia13, Griffith University14, Catalan Institution for Research and Advanced Studies15, Oak Ridge National Laboratory16, Joint Institute for Nuclear Research17, Aarhus University18, Washington University in St. Louis19, University of California, Santa Cruz20, Cardiff University21, Kunming Institute of Zoology22, China Agricultural University23, Tulane University24, Louisiana State University25, Copenhagen Zoo26, Federal University of Pará27, Oregon Health & Science University28, Technical University of Denmark29, Canterbury Museum30, Curtin University31, Novosibirsk State University32, Smithsonian Institution33, National University of Singapore34, National Museum of Natural History35, Nova Southeastern University36, Occidental College37, University of Edinburgh38, Harvard University39, University of California, San Francisco40, University of Florida41, University of Illinois at Urbana–Champaign42
TL;DR: A genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves recovered a highly resolved tree that confirms previously controversial sister or close relationships and identifies the first divergence in Neoaves, two groups the authors named Passerea and Columbea.
Abstract: To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergence in Neoaves, two groups we named Passerea and Columbea, representing independent lineages of diverse and convergently evolved land and water bird species. Among Passerea, we infer the common ancestor of core landbirds to have been an apex predator and confirm independent gains of vocal learning. Among Columbea, we identify pigeons and flamingoes as belonging to sister clades. Even with whole genomes, some of the earliest branches in Neoaves proved challenging to resolve, which was best explained by massive protein-coding sequence convergence and high levels of incomplete lineage sorting that occurred during a rapid radiation after the Cretaceous-Paleogene mass extinction event about 66 million years ago.
1,624 citations
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TL;DR: This work presents a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and shows that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods.
Abstract: Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
1,620 citations
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TL;DR: In this article, a version of the neoclassical growth model is used in which the key feature of aggregate technology is capital-skill complementarity: the elasticity of substitution is higher between capital equipment and unskilled workers than between skilled workers and capital equipment.
Abstract: The notion of skilled-biased technological change is often held responsible for the recent behavior of the U.S. skill premium, or the ratio between the wages of skilled and unskilled labor. This paper develops a framework for understanding this notion in terms of observable variables and uses the framework to evaluate the fraction of the skill premium's variation that is caused by changes in observables. A version of the neoclassical growth model is used in which the key feature of aggregate technology is capital-skill complementarity: the elasticity of substitution is higher between capital equipment and unskilled labor than between capital equipment and skilled labor. With this feature, changes in observables can account for nearly all the variation in the skill premium over the last 30 years. This finding suggests that increased wage inequality results from economic growth driven by new, efficient technologies embodied in capital equipment.
1,607 citations
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TL;DR: This tutorial provides a broad look at the field of limited feedback wireless communications, and reviews work in systems using various combinations of single antenna, multiple antenna, narrowband, broadband, single-user, and multiuser technology.
Abstract: It is now well known that employing channel adaptive signaling in wireless communication systems can yield large improvements in almost any performance metric. Unfortunately, many kinds of channel adaptive techniques have been deemed impractical in the past because of the problem of obtaining channel knowledge at the transmitter. The transmitter in many systems (such as those using frequency division duplexing) can not leverage techniques such as training to obtain channel state information. Over the last few years, research has repeatedly shown that allowing the receiver to send a small number of information bits about the channel conditions to the transmitter can allow near optimal channel adaptation. These practical systems, which are commonly referred to as limited or finite-rate feedback systems, supply benefits nearly identical to unrealizable perfect transmitter channel knowledge systems when they are judiciously designed. In this tutorial, we provide a broad look at the field of limited feedback wireless communications. We review work in systems using various combinations of single antenna, multiple antenna, narrowband, broadband, single-user, and multiuser technology. We also provide a synopsis of the role of limited feedback in the standardization of next generation wireless systems.
1,605 citations
Authors
Showing all 55232 results
Name | H-index | Papers | Citations |
---|---|---|---|
Meir J. Stampfer | 277 | 1414 | 283776 |
George M. Whitesides | 240 | 1739 | 269833 |
Michael Karin | 236 | 704 | 226485 |
Fred H. Gage | 216 | 967 | 185732 |
Rob Knight | 201 | 1061 | 253207 |
Martin White | 196 | 2038 | 232387 |
Simon D. M. White | 189 | 795 | 231645 |
Scott M. Grundy | 187 | 841 | 231821 |
Peidong Yang | 183 | 562 | 144351 |
Patrick O. Brown | 183 | 755 | 200985 |
Michael G. Rosenfeld | 178 | 504 | 107707 |
George M. Church | 172 | 900 | 120514 |
David Haussler | 172 | 488 | 224960 |
Yang Yang | 171 | 2644 | 153049 |
Alan J. Heeger | 171 | 913 | 147492 |