Showing papers by "University of California, Davis published in 2022"

Introducing Translation Studies: Theories and Applications

Abstract: A visual tour of Introducing Translation Studies List of figures and tables Acknowledgements List of abbreviations Introduction Chapter 1 Main issues of translation studies Chapter 2 Translation theory before the twentieth century Chapter 3 Equivalence and equivalent effect Chapter 4 Studying translation product and process Chapter 5 Functional theories of translation Chapter 6 Discourse and Register analysis approaches Chapter 7 Systems theories Chapter 8 Cultural and ideological turns Chapter 9 The role of the translator: visibility, ethics and sociology Chapter 10 Philosophical approaches to translation Chapter 11 New directions from the new media Chapter 12 Research and commentary projects Notes Bibliography Index

Replicability, Robustness, and Reproducibility in Psychological Science

Abstract: Replication-an important, uncommon, and misunderstood practice-is gaining appreciation in psychology. Achieving replicability is important for making research progress. If findings are not replicable, then prediction and theory development are stifled. If findings are replicable, then interrogation of their meaning and validity can advance knowledge. Assessing replicability can be productive for generating and testing hypotheses by actively confronting current understandings to identify weaknesses and spur innovation. For psychology, the 2010s might be characterized as a decade of active confrontation. Systematic and multi-site replication projects assessed current understandings and observed surprising failures to replicate many published findings. Replication efforts highlighted sociocultural challenges such as disincentives to conduct replications and a tendency to frame replication as a personal attack rather than a healthy scientific practice, and they raised awareness that replication contributes to self-correction. Nevertheless, innovation in doing and understanding replication and its cousins, reproducibility and robustness, has positioned psychology to improve research practices and accelerate progress. Expected final online publication date for the Annual Review of Psychology, Volume 73 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

A complete reference genome improves analysis of human genetic variation

Abstract: Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200 million base pairs of sequence, corrects thousands of structural errors, and unlocks the most complex regions of the human genome for clinical and functional study. We show how this reference universally improves read mapping and variant calling for 3202 and 17 globally diverse samples sequenced with short and long reads, respectively. We identify hundreds of thousands of variants per sample in previously unresolved regions, showcasing the promise of the T2T-CHM13 reference for evolutionary and biomedical discovery. Simultaneously, this reference eliminates tens of thousands of spurious variants per sample, including reduction of false positives in 269 medically relevant genes by up to a factor of 12. Because of these improvements in variant discovery coupled with population and functional genomic resources, T2T-CHM13 is positioned to replace GRCh38 as the prevailing reference for human genetics.

Parental COVID-19 Vaccine Hesitancy in the United States

Abstract: Little is known about parents' willingness to vaccinate their children against COVID-19. We assessed the prevalence of vaccine hesitancy among parents with a child or adolescent aged 12-15 years, examined predictors of parents' COVID-19 vaccine hesitancy, their reasons for resisting a pediatric COVID-19 vaccine, and the correlation between parents' intentions to vaccinate their child and the acceptance of a vaccine for themselves.We conducted a national online survey of 637 parents of a child or adolescent aged 12-15 years in March 2021, before COVID-19 vaccines had been approved for this age group. We assessed univariate predictors of vaccine hesitancy, and we used logistic regression analysis to assess independent effects of variables on vaccine hesitancy.Nearly one-third (28.9%; 95% CI, 25.5%-32.5%) of respondents reported pediatric vaccine hesitancy. Vaccine-hesitant parents were less knowledgeable about vaccines, more accepting of vaccine conspiracies, and less worried about COVID-19 risks to their child's health than vaccine-accepting parents were. Vaccine hesitancy was higher among female (vs male), single (vs married/living as married), older (vs younger), low income (vs high income), non-college graduates (vs college graduates), and Republican (vs Democrat) parents. The primary concerns expressed by vaccine-hesitant parents pertained to vaccine safety rather than vaccine effectiveness. One-quarter of vaccine-hesitant parents preferred that their child obtain immunity through infection rather than vaccination. Non-vaccine-hesitant parents' reasons for vaccinating focused on protecting the health of their child and others. Childhood COVID-19 vaccine acceptance was strongly associated with parents' intentions to get the vaccine for themselves.A messaging strategy for effective public health interventions that includes educating the public about vaccination, countering misinformation about vaccine development and safety, and stressing the safety of approved COVID-19 vaccines may boost vaccine acceptance among vaccine-hesitant parents.

Sarcopenia Is an Independent Risk Factor for Proximal Junctional Disease Following Adult Spinal Deformity Surgery.

Abstract: Study Design:Retrospective cohort study.Objectives:Sarcopenia is a risk factor for medical complications following spine surgery. However, the role of sarcopenia as a risk factor for proximal junct...

Reversible writing/deleting of magnetic skyrmions through hydrogen adsorption/desorption

Abstract: Magnetic skyrmions are topologically nontrivial spin textures with envisioned applications in energy-efficient magnetic information storage. Toggling the presence of magnetic skyrmions via writing/deleting processes is essential for spintronics applications, which usually require the application of a magnetic field, a gate voltage or an electric current. Here we demonstrate the reversible field-free writing/deleting of skyrmions at room temperature, via hydrogen chemisorption/desorption on the surface of Ni and Co films. Supported by Monte-Carlo simulations, the skyrmion creation/annihilation is attributed to the hydrogen-induced magnetic anisotropy change on ferromagnetic surfaces. We also demonstrate the role of hydrogen and oxygen on magnetic anisotropy and skyrmion deletion on other magnetic surfaces. Our results open up new possibilities for designing skyrmionic and magneto-ionic devices.

Human serum triggers antibiotic tolerance in Staphylococcus aureus

Abstract: Staphylococcus aureus frequently causes infections that are challenging to treat, leading to high rates of persistent and relapsing infection. Here, to understand how the host environment influences treatment outcomes, we study the impact of human serum on staphylococcal antibiotic susceptibility. We show that serum triggers a high degree of tolerance to the lipopeptide antibiotic daptomycin and several other classes of antibiotic. Serum-induced daptomycin tolerance is due to two independent mechanisms. Firstly, the host defence peptide LL-37 induces tolerance by triggering the staphylococcal GraRS two-component system, leading to increased peptidoglycan accumulation. Secondly, GraRS-independent increases in membrane cardiolipin abundance are required for full tolerance. When both mechanisms are blocked, S. aureus incubated in serum is as susceptible to daptomycin as when grown in laboratory media. Our work demonstrates that host factors can significantly modulate antibiotic susceptibility via diverse mechanisms, and combination therapy may provide a way to mitigate this.

Stimuli‐responsive crosslinked nanomedicine for cancer treatment

Abstract: Nanomedicines are attractive paradigms to deliver drugs, contrast agents, immunomodulators, and gene editors for cancer therapy and diagnosis. However, the currently developed nanomedicine suffers from poor serum stability, premature drug release, and lack of responsiveness. Crosslinking strategy can be utilized to overcome these shortcomings by employing stimuli-responsive chemical bonds to tightly hold the nanostructure and releasing the payloads spatiotemporally in a highly controlled manner. In this Review, we summarize the recently ingenious design of the stimuli-responsive crosslinked nanomedicines (SCN) in the field of cancer treatment and their advances in circumventing the drawbacks of the conventional drug delivery system. We classify the SCNs into three categories based on the crosslinking strategies, including built-in, on-surface, and inter-particle crosslinking nanomedicines. Thanks to the stimuli-responsive crosslinkages, SCNs are capable of keeping robust stability during systemic circulation. They also respond to the particular tumoral conditions to experience a series of dynamic changes, such as the changes in size, surface charge, targeting moieties, integrity, and imaging signals. These characteristics allow them to efficiently overcome different biological barriers and substantially improve the drug delivery efficiency, tumor-targeting ability, and imaging sensitivities. With the examples discussed, we envision that our perspectives can inspire more attempts to engineer intelligent nanomedicine to achieve effective cancer therapy and diagnosis.

Statistical Control Requires Causal Justification

Abstract: It is common practice in correlational or quasiexperimental studies to use statistical control to remove confounding effects from a regression coefficient. Controlling for relevant confounders can debias the estimated causal effect of a predictor on an outcome; that is, it can bring the estimated regression coefficient closer to the value of the true causal effect. But statistical control works only under ideal circumstances. When the selected control variables are inappropriate, controlling can result in estimates that are more biased than uncontrolled estimates. Despite the ubiquity of statistical control in published regression analyses and the consequences of controlling for inappropriate third variables, the selection of control variables is rarely explicitly justified in print. We argue that to carefully select appropriate control variables, researchers must propose and defend a causal structure that includes the outcome, predictors, and plausible confounders. We underscore the importance of causality when selecting control variables by demonstrating how regression coefficients are affected by controlling for appropriate and inappropriate variables. Finally, we provide practical recommendations for applied researchers who wish to use statistical control.

The Pandemic as a Portal: Reimagining Psychological Science as Truly Open and Inclusive

Abstract: Psychological science is at an inflection point: The COVID-19 pandemic has exacerbated inequalities that stem from our historically closed and exclusive culture. Meanwhile, reform efforts to change the future of our science are too narrow in focus to fully succeed. In this article, we call on psychological scientists-focusing specifically on those who use quantitative methods in the United States as one context for such conversations-to begin reimagining our discipline as fundamentally open and inclusive. First, we discuss whom our discipline was designed to serve and how this history produced the inequitable reward and support systems we see today. Second, we highlight how current institutional responses to address worsening inequalities are inadequate, as well as how our disciplinary perspective may both help and hinder our ability to craft effective solutions. Third, we take a hard look in the mirror at the disconnect between what we ostensibly value as a field and what we actually practice. Fourth and finally, we lead readers through a roadmap for reimagining psychological science in whatever roles and spaces they occupy, from an informal discussion group in a department to a formal strategic planning retreat at a scientific society.

Immune Response to Borrelia: Lessons from Lyme Disease Spirochetes.

Abstract: The mammalian host responds to infection with Borrelia spirochetes through a highly orchestrated immune defense involving innate and adaptive effector functions aimed toward limiting pathogen burdens, minimizing tissue injury, and preventing subsequent reinfection. The evolutionary adaptation of Borrelia spirochetes to their reservoir mammalian hosts may allow for its persistence despite this immune defense. This review summarizes our current understanding of the host immune response to B. burgdorferi sensu lato, the most widely studied Borrelia spp. and etiologic agent of Lyme borreliosis. Pertinent literature will be reviewed with emphasis on in vitro, ex vivo and animal studies that influenced our understanding of both the earliest responses to B. burgdorferi as it enters the mammalian host and those that evolve as spirochetes disseminate and establish infection in multiple tissues. Our focus is on the immune response of inbred mice, the most commonly studied animal model of B. burgdorferi infection and surrogate for one of this pathogen's principle natural reservoir hosts, the white-footed deer mouse. Comparison will be made to the immune responses of humans with Lyme borreliosis. Our goal is to provide an understanding of the dynamics of the mammalian immune response during infection with B. burgdorferi and its relation to the outcomes in reservoir (mouse) and non-reservoir (human) hosts.

Quantifying N leaching losses as a function of N balance: A path to sustainable food supply chains

Abstract: Growing public concern over agricultural nitrogen (N) pollution is now reflected in consumers’ food choices and shareholders’ resolutions, causing rapid changes in global food supply chains. Nitrate (NO3) leaching represents the primary N source for groundwater contamination and freshwater ecosystem degradation. However, simplified science-based indicators are still lacking to facilitate improved N management practices at the farm-level. We conducted a global analysis of published field studies to evaluate N balance (N inputs minus N outputs) as a robust predictor for NO3 losses. Using 82 studies (1110 observations) for rainfed cereal crops in temperate regions, we 1) quantified the response of NO3 losses to changes in N balance for major rainfed cereal crops while accounting for environmental and management variables; and 2) assessed the feasibility of improving water quality through lower N balance under different scenarios using the case study of maize (Zea mays L.) data from the US Corn Belt. Observations were grouped in studies from the US and non-US regions. Results show that NO3 losses increased exponentially as N balance increases for both the US and non-US regions, though they were 60% higher in the US at a given N balance. Scenario analysis revealed that reducing the N rate from the agronomic optimum to the lower point within the economic optimum N rate range decreased NO3 losses by 13% without impacting economic returns. The case study for maize showed that improvements in N use efficiency that increase grain yield at a given fertilizer rate can substantially reduce N balance and mitigate NO3 losses. This study provides an evidence-based foundation for food supply chain companies to mitigate global NO3 pollution, specifically by using the generalized relationships presented here to track progress in NO3 leaching mitigation. To further resolve uncertainties and improve region-specific estimates for NO3 losses, we propose a tiered monitoring and assessment framework similar to the IPCC (Intergovernmental Panel on Climate Change) methodology for N2O emissions, widely implemented in science and used for policy.