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Institution

University of California, Davis

EducationDavis, California, United States
About: University of California, Davis is a education organization based out in Davis, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 78770 authors who have published 180033 publications receiving 8064158 citations. The organization is also known as: UC Davis & UCD.
Topics: Population, Poison control, Gene, Galaxy, Genome


Papers
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Journal ArticleDOI
TL;DR: The opportunity to evaluate a large number of brain-injured patients to determine which lesioned brain areas might affect language comprehension was described, and it was suggested that the middle temporal gyrus may be more important for comprehension at the word level, while the other regions may play a greater role at the level of the sentence.

899 citations

Book
01 Jan 2001
TL;DR: The latest report from the Kauai Longitudinal Study addresses 2 fundamental questions of interest to pediatricians and health care professionals: What are the long-term effects of adverse perinatal and early child-rearing conditions on individuals’ physical, cognitive, and psychosocial development at midlife?
Abstract: The latest report from the Kauai Longitudinal Study addresses 2 fundamental questions of interest to pediatricians and health care professionals: 1) What are the long-term effects of adverse perinatal and early child-rearing conditions on individuals’ physical, cognitive, and psychosocial development at midlife? 2) Which protective factors allow most individuals who are exposed to multiple childhood risk factors to make a successful adaptation in adulthood?1 The Kauai Longitudinal Study has monitored the impact of a wide array of biological, psychological, and social risk factors on the lives of a multiracial cohort of 698 individuals who were born in 1955 on the Hawaiian island of Kauai, from the perinatal … Reprint requests to (E.E.W.) Department of Human and Community Development, University of California, Davis, CA 95616. E-mail: eewerner{at}ucdavis.edu

899 citations

Journal ArticleDOI
TL;DR: Findings indicate that prefrontal regions are critical for the organism's response to unexpected novel stimuli, and abnormalities in prefrontal control of sensory-limbic integration may be a critical element in the decreased P300 to novel stimuli found in these unilateral prefrontal lesioned patients.

899 citations

Journal ArticleDOI
TL;DR: The objectively compiled list of invasive species presented here provides a snapshot of the current dimensions of the phenomenon and will be useful for screening new introductions for invasive potential.
Abstract: Aim Woody plants were not widely considered to be important invasive alien species until fairly recently. Thousands of species of trees and shrubs have, however, been moved around the world. Many species have spread from planting sites, and some are now among the most widespread and damaging of invasive organisms. This article presents a global list of invasive alien trees and shrubs. It discusses taxonomic biases, geographical patterns, modes of dispersal, reasons for introductions and key issues regarding invasions of non-native woody plants around the world. Location Global. Methods An exhaustive survey was made of regional and national databases and the literature. Correspondence with botanists and ecologists and our own observations in many parts of the world expanded the list. Presence of invasive species was determined for each of 15 broad geographical regions. The main reasons for introduction and dissemination were determined for each species. Results The list comprises 622 species (357 trees, 265 shrubs in 29 plant orders, 78 families, 286 genera). Regions with the largest number of woody invasive alien species are: Australia (183); southern Africa (170); North America (163); Pacific Islands (147); and New Zealand (107). Species introduced for horticulture dominated the list (62% of species: 196 trees and 187 shrubs). The next most important reasons for introduction and dissemination were forestry (13%), food (10%) and agroforestry (7%). Three hundred and twenty-three species (52%) are currently known to be invasive in only one region, and another 126 (20%) occur in only two regions. Only 38 species (6%) are very widespread (invasive in six or more regions). Over 40% of invasive tree species and over 60% of invasive shrub species are bird dispersed. Main conclusions Only between 0.5% and 0.7% of the world’s tree and shrub species are currently invasive outside their natural range, but woody plant invasions are rapidly increasing in importance around the world. The objectively compiled list of invasive species presented here provides a snapshot of the current dimensions of the phenomenon and will be useful for screening new introductions for invasive potential.

898 citations

Journal ArticleDOI
TL;DR: It is reported that patients with CD of the ileum have reduced antibacterial activity in their intestinal mucosal extracts, and changes in HD5 expression levels, comparable to those observed in CD, had a pronounced impact on the luminal microbiota.
Abstract: The pathogenesis of Crohn′s disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the small intestine, including human α-defensins HD5 and HD6. We tested the hypothesis that reduced expression of PC α-defensins compromises mucosal host defenses and predisposes patients to CD of the ileum. We report that patients with CD of the ileum have reduced antibacterial activity in their intestinal mucosal extracts. These specimens also showed decreased expression of PC α-defensins, whereas the expression of eight other PC products either remained unchanged or increased when compared with controls. The specific decrease of α-defensins was independent of the degree of inflammation in the specimens and was not observed in either CD of the colon, ulcerative colitis, or pouchitis. The functional consequence of α-defensin expression levels was examined by using a transgenic mouse model, where we found changes in HD5 expression levels, comparable to those observed in CD, had a pronounced impact on the luminal microbiota. Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease.

896 citations


Authors

Showing all 79538 results

NameH-indexPapersCitations
Eric S. Lander301826525976
Ronald C. Kessler2741332328983
George M. Whitesides2401739269833
Ronald M. Evans199708166722
Virginia M.-Y. Lee194993148820
Scott M. Grundy187841231821
Julie E. Buring186950132967
Patrick O. Brown183755200985
Anil K. Jain1831016192151
John C. Morris1831441168413
Douglas R. Green182661145944
John R. Yates1771036129029
Barry Halliwell173662159518
Roderick T. Bronson169679107702
Hongfang Liu1662356156290
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023262
20221,122
20218,398
20208,661
20198,165
20187,556