Institution
University of California, Davis
Education•Davis, California, United States•
About: University of California, Davis is a education organization based out in Davis, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 78770 authors who have published 180033 publications receiving 8064158 citations. The organization is also known as: UC Davis & UCD.
Topics: Population, Poison control, Gene, Galaxy, Genome
Papers published on a yearly basis
Papers
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TL;DR: It is shown that the closely related SHATTERPROOF (SHP1) and SHP2 ) MADS-box genes are required for fruit dehiscence in Arabidopsis, and that further analysis of the molecular events underlying fruit deHiscence may allow genetic manipulation of pod shatter in crop plants.
Abstract: The fruit, which mediates the maturation and dispersal of seeds, is a complex structure unique to flowering plants. Seed dispersal in plants such as Arabidopsis occurs by a process called fruit dehiscence, or pod shatter. Few studies have focused on identifying genes that regulate this process, in spite of the agronomic value of controlling seed dispersal in crop plants such as canola. Here we show that the closely related SHATTERPROOF (SHP1) and SHATTERPROOF2 (SHP2) MADS-box genes are required for fruit dehiscence in Arabidopsis. Moreover, SHP1 and SHP2 are functionally redundant, as neither single mutant displays a novel phenotype. Our studies of shp1 shp2 fruit, and of plants constitutively expressing SHP1 and SHP2, show that these two genes control dehiscence zone differentiation and promote the lignification of adjacent cells. Our results indicate that further analysis of the molecular events underlying fruit dehiscence may allow genetic manipulation of pod shatter in crop plants.
833 citations
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TL;DR: This article described a social psychological framework for understanding sexual stigma, and reported data on sexual minority individuals' stigma-related experiences, including self-stigma or negative attitudes toward the self.
Abstract: This article describes a social psychological framework for understanding sexual stigma, and it reports data on sexual minority individuals' stigma-related experiences. The framework distinguishes between stigma's manifestations in society's institutions (heterosexism) and among individuals. The latter include enacted sexual stigma (overt negative actions against sexual minorities, such as hate crimes), felt sexual stigma (expectations about the circumstances in which sexual stigma will be enacted), and internalized sexual stigma (personal acceptance of sexual stigma as part of one's value system and self-concept). Drawing from previous research on internalized sexual stigma among heterosexuals (i.e., sexual prejudice), the article considers possible parallels in how sexual minorities experience internalized sexual stigma (i.e., self-stigma, or negative attitudes toward the self). Data are presented from a community sample of lesbian, gay, and bisexual adults (N = 2,259) to illustrate the model's utility for generating and testing hypotheses concerning self-stigma.
833 citations
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TL;DR: Wheat compensates for the diversity bottlenecks expected from recent domestication and polyploid speciation events by capturing part of the genetic diversity of its progenitors and by generating new diversity at a relatively fast pace.
Abstract: Wheat was domesticated about 10,000 years ago and has since spread worldwide to become one of the major crops. Its adaptability to diverse environments and end uses is surprising given the diversity bottlenecks expected from recent domestication and polyploid speciation events. Wheat compensates for these bottlenecks by capturing part of the genetic diversity of its progenitors and by generating new diversity at a relatively fast pace. Frequent gene deletions and disruptions generated by a fast replacement rate of repetitive sequences are buffered by the polyploid nature of wheat, resulting in subtle dosage effects on which selection can operate.
832 citations
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Mayo Clinic1, Northwestern University2, Yale University3, New York University4, Baylor College of Medicine5, University of Texas Medical Branch6, University of Pennsylvania7, University of California, San Diego8, Allegheny General Hospital9, Medical University of South Carolina10, St. Joseph's Hospital and Medical Center11, University of California, Davis12, University of Washington13
TL;DR: Studies in animals indicate that methylprednisolone and naloxone are both potentially beneficial in acute spinal-cord injury, but whether any treatment is clinically effective remains uncertain.
Abstract: Studies in animals indicate that methylprednisolone and naloxone are both potentially beneficial in acute spinal-cord injury, but whether any treatment is clinically effective remains uncertain. We evaluated the efficacy and safety of methylprednisolone and naloxone in a multicenter randomized, double-blind, placebo-controlled trial in patients with acute spinal-cord injury, 95 percent of whom were treated within 14 hours of injury. Methylprednisolone was given to 162 patients as a bolus of 30 mg per kilogram of body weight, followed by infusion at 5.4 mg per kilogram per hour for 23 hours. Naloxone was given to 154 patients as a bolus of 5.4 mg per kilogram, followed by infusion at 4.0 mg per kilogram per hour for 23 hours. Placebos were given to 171 patients by bolus and infusion. Motor and sensory functions were assessed by systematic neurologic examination on admission and six weeks and six months after injury. After six months the patients who were treated with methylprednisolone within eigh...
832 citations
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TL;DR: An overview of the developmental processes that shape the B-1 cell pool in mice is provided, the functions of B- 1 cells in both the steady state and during host defence are outlined, and possible functional B-2 cell homologues that exist in humans are discussed.
Abstract: In this Review, Nicole Baumgarth describes the development and functions of B-1 cells. These innate-like B cells serve as the major source of natural antibody in mice, and can have important roles in defence against mucosal pathogens and in maintaining tissue homeostasis. During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.
832 citations
Authors
Showing all 79538 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eric S. Lander | 301 | 826 | 525976 |
Ronald C. Kessler | 274 | 1332 | 328983 |
George M. Whitesides | 240 | 1739 | 269833 |
Ronald M. Evans | 199 | 708 | 166722 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Scott M. Grundy | 187 | 841 | 231821 |
Julie E. Buring | 186 | 950 | 132967 |
Patrick O. Brown | 183 | 755 | 200985 |
Anil K. Jain | 183 | 1016 | 192151 |
John C. Morris | 183 | 1441 | 168413 |
Douglas R. Green | 182 | 661 | 145944 |
John R. Yates | 177 | 1036 | 129029 |
Barry Halliwell | 173 | 662 | 159518 |
Roderick T. Bronson | 169 | 679 | 107702 |
Hongfang Liu | 166 | 2356 | 156290 |