University of California, Irvine

About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.

Phase II Study of Bevacizumab in Patients With Platinum-Resistant Ovarian Cancer or Peritoneal Serous Cancer

Abstract: Purpose We evaluated the efficacy and safety of bevacizumab in patients with platinum-resistant epithelial ovarian carcinoma (EOC) or peritoneal serous carcinoma (PSC) who had experienced disease progression during, or within 3 months of discontinuing, topotecan or liposomal doxorubicin. Patients and Methods No more than three prior treatment regimens were allowed. Patients received single-agent bevacizumab 15 mg/kg intravenously every 3 weeks. Response was assessed by computed tomography (CT) scan every 6 weeks using Response Evaluation Criteria in Solid Tumors (RECIST). Results Of 44 patients treated, 83.7% were primarily platinum resistant, 59.1% had received liposomal doxorubicin, 25% topotecan, 15.9% both agents, and 47.7% had received three prior chemotherapy regimens. A median of five (range, two to 16) bevacizumab doses were administered. Partial responses were observed in seven patients (15.9%). Median progression-free survival was 4.4 months (95% CI, 3.1 to 5.5 months), with a median survival du...

Whatever Does Not Kill Us: Cumulative Lifetime Adversity, Vulnerability, and Resilience

Abstract: Exposure to adverse life events typically predicts subsequent negative effects on mental health and well-being, such that more adversity predicts worse outcomes. However, adverse experiences may also foster subsequent resilience, with resulting advantages for mental health and well-being. In a multiyear longitudinal study of a national sample, people with a history of some lifetime adversity reported better mental health and well-being outcomes than not only people with a high history of adversity but also than people with no history of adversity. Specifically, U-shaped quadratic relationships indicated that a history of some but nonzero lifetime adversity predicted relatively lower global distress, lower self-rated functional impairment, fewer posttraumatic stress symptoms, and higher life satisfaction over time. Furthermore, people with some prior lifetime adversity were the least affected by recent adverse events. These results suggest that, in moderation, whatever does not kill us may indeed make us stronger.

Cosmological Simulations with Self-Interacting Dark Matter I: Constant Density Cores and Substructure

Abstract: We use cosmological simulations to study the effects of self-interacting dark matter (SIDM) on the density profiles and substructure counts of dark matte r halos from the scales of spiral galaxies to galaxy clusters, focusing explicitly on mod els with cross sections over dark matter particle mass σ/m = 1 and 0.1 cm 2 /g. Our simulations rely on a new SIDM N-body algorithm that is derived self-consistently from the Boltz mann equation and that reproduces analytic expectations in controlled numerical experiments. We find that well-resolved SIDM halos have constant-density cores, with significantly lowe r central densities than their CDM counterparts. In contrast, the subhalo content of SIDM halos is only modestly reduced compared to CDM, with the suppression greatest for large hosts and small halo-centric distances. Moreover, the large-scale clustering and halo circular vel ocity functions in SIDM are effectively identical to CDM, meaning that all of the large-scale successes of CDM are equally well matched by SIDM. From our largest cross section runs we are able to extract scaling relations for core sizes and central densities over a range o f halo sizes and find a strong correlation between the core radius of an SIDM halo and the NFW scale radius of its CDM counterpart. We construct a simple analytic model, based on CDM scaling relations, that captures all aspects of the scaling relations for SIDM halos. Our results show that halo core densities in σ/m = 1 cm 2 /g models are too low to match observations of galaxy clusters, low surface brightness spirals (LSBs), and dwarf spheroidal galaxies. However, SIDM with σ/m ≃ 0.1 cm 2 /g appears capable of reproducing reported core sizes and central densities of dwarfs, LSBs, and galaxy clusters without the need for velocity dependence. Higher resolution simulations over a wider range of masses will be required to confirm this expectation. We discuss constraints arising from the Bullet cluster observ ations, measurements of dark matter density on small-scales and subhalo survival requirements, and show that SIDM models with σ/m ≃ 0.1 cm 2 /g ≃ 0.2 barn/GeV are consistent with all observational constraints.

A neural dissociation within language: Evidence that the mental dictionary is part of declarative memory, and that grammatical rules are processed by the procedural system

Abstract: Language comprises a lexicon for storing words and a grammar for generating rule-governed forms. Evidence is presented that the lexicon is part of a temporal-parietalhnedial-temporal “declarative memory” system and that granlmatical rules are processed by a frontamasal-ganglia “procedural” system. Patients produced past tenses of regular and novel verbs (looked and plagged), which require an -ed-suffixation rule, and irregular verbs (dug), which are retrieved from memory. Word-finding difficulties in posterior aphasia, and the general declarative memory impairment in Alzheimer's disease, led to more errors with irregular than regular and novel verbs. Grammatical difficulties in anterior aphasia, and the general impairment of procedures in Parkinson's disease, led to the opposite pattern. In contrast to the Parkinson's patients, who showed sup pressed motor activity and rule use, Huntington's disease patients showed excess motor activity and rule use, underscoring a role for the basal ganglia in grammatical processing.

Satellites measure recent rates of groundwater depletion in California's Central Valley

Abstract: In highly-productive agricultural areas such as California's Central Valley, where groundwater often supplies the bulk of the water required for irrigation, quantifying rates of groundwater depletion remains a challenge owing to a lack of monitoring infrastructure and the absence of water use reporting requirements. Here we use 78 months (October, 2003–March, 2010) of data from the Gravity Recovery and Climate Experiment satellite mission to estimate water storage changes in California's Sacramento and San Joaquin River Basins. We find that the basins are losing water at a rate of 31.0 ± 2.7 mm yr−1 equivalent water height, equal to a volume of 30.9 km3 for the study period, or nearly the capacity of Lake Mead, the largest reservoir in the United States. We use additional observations and hydrological model information to determine that the majority of these losses are due to groundwater depletion in the Central Valley. Our results show that the Central Valley lost 20.4 ± 3.9 mm yr−1 of groundwater during the 78-month period, or 20.3 km3 in volume. Continued groundwater depletion at this rate may well be unsustainable, with potentially dire consequences for the economic and food security of the United States.