University of California, Irvine

About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.

Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement

Abstract: The broad-spectrum herbicide glyphosate (common trade name “Roundup”) was first sold to farmers in 1974. Since the late 1970s, the volume of glyphosate-based herbicides (GBHs) applied has increased approximately 100-fold. Further increases in the volume applied are likely due to more and higher rates of application in response to the widespread emergence of glyphosate-resistant weeds and new, pre-harvest, dessicant use patterns. GBHs were developed to replace or reduce reliance on herbicides causing well-documented problems associated with drift and crop damage, slipping efficacy, and human health risks. Initial industry toxicity testing suggested that GBHs posed relatively low risks to non-target species, including mammals, leading regulatory authorities worldwide to set high acceptable exposure limits. To accommodate changes in GBH use patterns associated with genetically engineered, herbicide-tolerant crops, regulators have dramatically increased tolerance levels in maize, oilseed (soybeans and canola), and alfalfa crops and related livestock feeds. Animal and epidemiology studies published in the last decade, however, point to the need for a fresh look at glyphosate toxicity. Furthermore, the World Health Organization’s International Agency for Research on Cancer recently concluded that glyphosate is “probably carcinogenic to humans.” In response to changing GBH use patterns and advances in scientific understanding of their potential hazards, we have produced a Statement of Concern drawing on emerging science relevant to the safety of GBHs. Our Statement of Concern considers current published literature describing GBH uses, mechanisms of action, toxicity in laboratory animals, and epidemiological studies. It also examines the derivation of current human safety standards. We conclude that: (1) GBHs are the most heavily applied herbicide in the world and usage continues to rise; (2) Worldwide, GBHs often contaminate drinking water sources, precipitation, and air, especially in agricultural regions; (3) The half-life of glyphosate in water and soil is longer than previously recognized; (4) Glyphosate and its metabolites are widely present in the global soybean supply; (5) Human exposures to GBHs are rising; (6) Glyphosate is now authoritatively classified as a probable human carcinogen; (7) Regulatory estimates of tolerable daily intakes for glyphosate in the United States and European Union are based on outdated science. We offer a series of recommendations related to the need for new investments in epidemiological studies, biomonitoring, and toxicology studies that draw on the principles of endocrinology to determine whether the effects of GBHs are due to endocrine disrupting activities. We suggest that common commercial formulations of GBHs should be prioritized for inclusion in government-led toxicology testing programs such as the U.S. National Toxicology Program, as well as for biomonitoring as conducted by the U.S. Centers for Disease Control and Prevention.

Combined co and dust scaling relations of depletion time and molecular gas fractions with cosmic time, specific star-formation rate, and stellar mass

Abstract: We combine molecular gas masses inferred from CO emission in 500 star-forming galaxies (SFGs) between z = 0 and 3, from the IRAM-COLDGASS, PHIBSS1/2, and other surveys, with gas masses derived from Herschel far-IR dust measurements in 512 galaxy stacks over the same stellar mass/redshift range. We constrain the scaling relations of molecular gas depletion timescale (t depl) and gas to stellar mass ratio (M mol gas/M* ) of SFGs near the star formation "main-sequence" with redshift, specific star-formation rate (sSFR), and stellar mass (M* ). The CO- and dust-based scaling relations agree remarkably well. This suggests that the CO → H2 mass conversion factor varies little within ±0.6 dex of the main sequence (sSFR(ms, z, M *)), and less than 0.3 dex throughout this redshift range. This study builds on and strengthens the results of earlier work. We find that t depl scales as (1 + z)–0.3 × (sSFR/sSFR(ms, z, M *))–0.5, with little dependence on M *. The resulting steep redshift dependence of M mol gas/M * ≈ (1 + z)3 mirrors that of the sSFR and probably reflects the gas supply rate. The decreasing gas fractions at high M* are driven by the flattening of the SFR-M * relation. Throughout the probed redshift range a combination of an increasing gas fraction and a decreasing depletion timescale causes a larger sSFR at constant M *. As a result, galaxy integrated samples of the M mol gas-SFR rate relation exhibit a super-linear slope, which increases with the range of sSFR. With these new relations it is now possible to determine M mol gas with an accuracy of ±0.1 dex in relative terms, and ±0.2 dex including systematic uncertainties.

Rapid method for direct extraction of DNA from soil and sediments.

Abstract: A rapid method for the direct extraction of DNA from soil and sediments was developed. The indigenous microorganisms in the soil and sediments were lysed by using lysozyme and a freeze-thaw procedure. The lysate was extracted with sodium dodecyl sulfate and phenol-chloroform. In addition to a high recovery efficiency (greater than 90%), the yields of DNA were high (38 and 12 micrograms/g [wet weight] from sediments and soil, respectively). This method generated minimal shearing of the extracted DNA. The crude DNA could be further purified with an Elutip-d column if necessary. An additional advantage of this method is that only 1 g of sample is required, which allows for the analysis of small samples and the processing of many samples in a relatively short (7 h) period.

PHOAKS: a system for sharing recommendations

Abstract: The feasibility of automatic recognition of recommendations is supported by empirical results. First, Usenet messages are a significant source of recommendations of Web resources: 23% of Usenet messages mention Web resources, and ?>0% of these mentions are recommendations. Second, recommendation instances can be machine-recognized with nearly 90% accuracy. Third, some resources are recommended by more than one person. These multiconfirmed recommendations appear to be significant resources for the relevant community. Finally, the number of distinct recommenders of a resource is a tallying, and redistributing recom-

Increasing rates of ice mass loss from the Greenland and Antarctic ice sheets revealed by GRACE

Abstract: [1] We use monthly measurements of time-variable gravity from the GRACE (Gravity Recovery and Climate Experiment) satellite gravity mission to determine the ice mass-loss for the Greenland and Antarctic Ice Sheets during the period between April 2002 and February 2009. We find that during this time period the mass loss of the ice sheets is not a constant, but accelerating with time, i.e., that the GRACE observations are better represented by a quadratic trend than by a linear one, implying that the ice sheets contribution to sea level becomes larger with time. In Greenland, the mass loss increased from 137 Gt/yr in 2002–2003 to 286 Gt/yr in 2007–2009, i.e., an acceleration of −30 ± 11 Gt/yr2 in 2002–2009. In Antarctica the mass loss increased from 104 Gt/yr in 2002–2006 to 246 Gt/yr in 2006–2009, i.e., an acceleration of −26 ± 14 Gt/yr2 in 2002–2009. The observed acceleration in ice sheet mass loss helps reconcile GRACE ice mass estimates obtained for different time periods.