Institution
University of California, Irvine
Education•Irvine, California, United States•
About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.
Topics: Population, Galaxy, Poison control, Cancer, Gene
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In situ hybridization and nuclease protection analyses demonstrate that limbic seizures dramatically increase the amount of messenger RNA for NGF in the neurons of the hippocampal dentate gyrus within 1 hour of seizure onset and in broadly distributed neocortical and olfactory forebrain neurons some hours later.
Abstract: Nerve growth factor (NGF) produced by telencephalic neurons provides critical trophic support for cholinergic neurons of the basal forebrain. In situ hybridization and nuclease protection analyses demonstrate that limbic seizures dramatically increase the amount of messenger RNA for NGF in the neurons of the hippocampal dentate gyrus within 1 hour of seizure onset and in broadly distributed neocortical and olfactory forebrain neurons some hours later. The increased messenger RNA species is indistinguishable from messenger RNA for transcript B of the beta subunit of NGF from mouse submandibular gland. Thus, the expression of a known growth factor is affected by unusual physiological activity, suggesting one route through which trophic interactions between neurons in adult brain can be modified.
629 citations
••
University of Padua1, University of California, Irvine2, Royal Melbourne Hospital3, Memorial Sloan Kettering Cancer Center4, University of Hamburg5, Vita-Salute San Raffaele University6, Henry Ford Hospital7, Florida Hospital Celebration Health8, Netherlands Cancer Institute9, Cornell University10, City of Hope National Medical Center11
TL;DR: This update of previous systematic reviews of the literature showed, for the first time, a significant advantage in favor of RARP in comparison with RRP in terms of 12-mo potency rates.
629 citations
••
TL;DR: The prevalence of mild cognitive impairment and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study was determined, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center.
Abstract: Objective To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study. Design The CHS Cognition Study is an ancillary study of the CHS that was conducted to determine the presence of MCI and dementia in the CHS cohort. Setting Multicenter population study. Patients We examined 3608 participants in the CHS who had undergone detailed neurological, neuropsychological, neuroradiological, and psychiatric testing to identify dementia and MCI. Main Outcome Measures The prevalence of MCI was determined for the whole cohort, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center (n = 927). Mild cognitive impairment was classified as either MCI amnestic-type or MCI multiple cognitive deficits–type. Results The overall prevalence of MCI was 19% (465 of 2470 participants); prevalence increased with age from 19% in participants younger than 75 years to 29% in those older than 85 years. The overall prevalence of MCI at the Pittsburgh center was 22% (130 of 599 participants); prevalence of the MCI amnesic-type was 6% and of the MCI multiple cognitive deficits–type was 16%. Conclusions Twenty-two percent of the participants aged 75 years or older had MCI. Mild cognitive impairment is a heterogenous syndrome, where the MCI amnestic-type is less frequent than the MCI multiple cognitive deficits–type. Most of the participants with MCI had comorbid conditions that may affect their cognitive functions.
629 citations
••
Karolinska Institutet1, Federal University of São Paulo2, Vanderbilt University3, University of California, Irvine4, University of California, Davis5, Baylor College of Medicine6, United States Department of Veterans Affairs7, Emory University8, University of Würzburg9, University of Hong Kong10, VU University Amsterdam11
TL;DR: This consensus statement of current knowledge on the etiology of PEW syndrome in CKD is provided to increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of Pew.
628 citations
••
TL;DR: It is argued that blockchain (BC), a disruptive technology that has found many applications from cryptocurrencies to smart contracts, is a potential solution to these challenges and is proposed a BC-based architecture to protect the privacy of users and to increase the security of the vehicular ecosystem.
Abstract: Interconnected smart vehicles offer a range of sophisticated services that benefit the vehicle owners, transport authorities, car manufacturers, and other service providers. This potentially exposes smart vehicles to a range of security and privacy threats such as location tracking or remote hijacking of the vehicle. In this article, we argue that blockchain (BC), a disruptive technology that has found many applications from cryptocurrencies to smart contracts, is a potential solution to these challenges. We propose a BC-based architecture to protect the privacy of users and to increase the security of the vehicular ecosystem. Wireless remote software updates and other emerging services such as dynamic vehicle insurance fees are used to illustrate the efficacy of the proposed security architecture. We also qualitatively argue the resilience of the architecture against common security attacks.
627 citations
Authors
Showing all 47751 results
Name | H-index | Papers | Citations |
---|---|---|---|
Daniel Levy | 212 | 933 | 194778 |
Rob Knight | 201 | 1061 | 253207 |
Lewis C. Cantley | 196 | 748 | 169037 |
Dennis W. Dickson | 191 | 1243 | 148488 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Joseph Biederman | 179 | 1012 | 117440 |
John R. Yates | 177 | 1036 | 129029 |
John A. Rogers | 177 | 1341 | 127390 |
Avshalom Caspi | 170 | 524 | 113583 |
Yang Gao | 168 | 2047 | 146301 |
Carl W. Cotman | 165 | 809 | 105323 |
John H. Seinfeld | 165 | 921 | 114911 |
Gregg C. Fonarow | 161 | 1676 | 126516 |
Jerome I. Rotter | 156 | 1071 | 116296 |
David Cella | 156 | 1258 | 106402 |