University of California, Santa Barbara

About: University of California, Santa Barbara is a education organization based out in Santa Barbara, California, United States. It is known for research contribution in the topics: Population & Laser. The organization has 30281 authors who have published 80852 publications receiving 4626827 citations. The organization is also known as: UC Santa Barbara & UCSB.

MoS2 Field-Effect Transistor for Next-Generation Label-Free Biosensors

Abstract: Biosensors based on field-effect transistors (FETs) have attracted much attention, as they offer rapid, inexpensive, and label-free detection. While the low sensitivity of FET biosensors based on bulk 3D structures has been overcome by using 1D structures (nanotubes/nanowires), the latter face severe fabrication challenges, impairing their practical applications. In this paper, we introduce and demonstrate FET biosensors based on molybdenum disulfide (MoS2), which provides extremely high sensitivity and at the same time offers easy patternability and device fabrication, due to its 2D atomically layered structure. A MoS2-based pH sensor achieving sensitivity as high as 713 for a pH change by 1 unit along with efficient operation over a wide pH range (3–9) is demonstrated. Ultrasensitive and specific protein sensing is also achieved with a sensitivity of 196 even at 100 femtomolar concentration. While graphene is also a 2D material, we show here that it cannot compete with a MoS2-based FET biosensor, which ...

Detecting spammers on social networks

Abstract: Social networking has become a popular way for users to meet and interact online. Users spend a significant amount of time on popular social network platforms (such as Facebook, MySpace, or Twitter), storing and sharing a wealth of personal information. This information, as well as the possibility of contacting thousands of users, also attracts the interest of cybercriminals. For example, cybercriminals might exploit the implicit trust relationships between users in order to lure victims to malicious websites. As another example, cybercriminals might find personal information valuable for identity theft or to drive targeted spam campaigns.In this paper, we analyze to which extent spam has entered social networks. More precisely, we analyze how spammers who target social networking sites operate. To collect the data about spamming activity, we created a large and diverse set of "honey-profiles" on three large social networking sites, and logged the kind of contacts and messages that they received. We then analyzed the collected data and identified anomalous behavior of users who contacted our profiles. Based on the analysis of this behavior, we developed techniques to detect spammers in social networks, and we aggregated their messages in large spam campaigns. Our results show that it is possible to automatically identify the accounts used by spammers, and our analysis was used for take-down efforts in a real-world social network. More precisely, during this study, we collaborated with Twitter and correctly detected and deleted 15,857 spam profiles.

Fractional Statistics and the Quantum Hall Effect

Abstract: The statistics of quasiparticles entering the quantum Hall effect are deduced from the adiabatic theorem. These excitations are found to obey fractional statistics, a result closely related to their fractional charge.

Prescription for experimental determination of the dynamics of a quantum black box

Abstract: We give an explicit way to experimentally determine the evolution operators which completely describe the dynamics of a quantum-mechanical black box: an arbitrary open quantum system. We show necessary and sufficient conditions for this to be possible and illustrate the general theory by considering specifically one-and two-quantum-bit systems. These procedures may be useful in the comparative evaluation of experimental quantum measurement, communication and computation systems.

Silicon metabolism in diatoms: implications for growth

Abstract: Diatoms are the world's largest contributors to biosilicification and are one of the predominant contributors to global carbon fixation. Silicon is a major limiting nutrient for diatom growth and hence is a controlling factor in primary productivity. Because our understanding of the cellular metabolism of silicon is limited, we are not fully knowledgeable about intracellular factors that may affect diatom productivity in the oceans. The goal of this review is to present an overview of silicon metabolism in diatoms and to identify areas for future research. Numerous studies have characterized parameters of silicic acid uptake by diatoms, and molecular characterization of transport has begun with the isolation of genes encoding the transporter proteins. Multiple types of silicic acid transporter gene have been identified in a single diatom species, and multiple types appear to be present in all diatom species. The controlled expression and perhaps localization of the transporters in the cell may be factors in the overall regulation of silicic acid uptake. Transport can also be regulated by the rate of silica incorporation into the cell wall, suggesting that an intracellular sensing and control mechanism couples transport with incorporation. Sizable intracellular pools of soluble silicon have been identified in diatoms, at levels well above saturation for silica solubility, yet the mechanism for maintenance of supersaturated levels has not been determined. The mechanism of intracellular transport of silicon is also unknown, but this must be an important part of the silicification process because of the close coupling between silica incorporation and uptake. Although detailed ultrastructural analyses of silica deposition have been reported, we know little about the molecular details of this process. However, proteins occluded within silica that promote silicification in vitro have recently been characterized, and the application of molecular techniques holds the promise of great advances in this area. Cellular energy for silicification and transport comes from aerobic respiration without any direct involvement of photosynthetic energy. As such, diatom silicon metabolism differs from that of other major limiting nutrients such as nitrogen and phosphorous, which are closely linked to photosynthetic metabolism. Cell wall silicification and silicic acid transport are tightly coupled to the cell cycle, which results in a dependency in the extent of silicification on growth rate. Silica dissolution is an important part of diatom cellular silicon metabolism, because dissolution must be prevented in the living cell, and because much of the raw material for mineralization in natural assemblages is supplied by dissolution of dead cells. Perhaps part of the reason for the ecological success of diatoms is due to their use of a silicified cell wall, which has been calculated to impart a substantial energy savings to organisms that have them. However, the growth of diatoms and other siliceous organisms has depleted the oceans of silicon, such that silicon availability is now a major factor in the control of primary productivity. Much new progress in understanding silicon metabolism in diatoms is expected because of the application of molecular approaches and sophisticated analytical techniques. Such insight is likely to lead to a greater understanding of the role of silicon in controlling diatom growth, and hence primary productivity, and of the mechanisms involved in the formation of the intricate silicified structures of the diatom cell wall.