University of California, Santa Barbara

About: University of California, Santa Barbara is a education organization based out in Santa Barbara, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 30281 authors who have published 80852 publications receiving 4626827 citations. The organization is also known as: UC Santa Barbara & UCSB.

An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery

Abstract: A two-dimensional columnar phase in mixtures of DNA complexed with cationic liposomes has been found in the lipid composition regime known to be significantly more efficient at transfecting mammalian cells in culture compared to the lamellar (LalphaC) structure of cationic liposome-DNA complexes. The structure, derived from synchrotron x-ray diffraction, consists of DNA coated by cationic lipid monolayers and arranged on a two-dimensional hexagonal lattice (HIIC). Two membrane-altering pathways induce the LalphaC --> HIIC transition: one where the spontaneous curvature of the lipid monolayer is driven negative, and another where the membrane bending rigidity is lowered with a new class of helper-lipids. Optical microscopy revealed that the LalphaC complexes bind stably to anionic vesicles (models of cellular membranes), whereas the more transfectant HIIC complexes are unstable and rapidly fuse and release DNA upon adhering to anionic vesicles.

Black Holes: Complementarity or Firewalls?

Abstract: We argue that the following three statements cannot all be true: (i) Hawking radiation is in a pure state, (ii) the information carried by the radiation is emitted from the region near the horizon, with low energy effective field theory valid beyond some microscopic distance from the horizon, and (iii) the infalling observer encounters nothing unusual at the horizon. Perhaps the most conservative resolution is that the infalling observer burns up at the horizon. Alternatives would seem to require novel dynamics that nevertheless cause notable violations of semiclassical physics at macroscopic distances from the horizon.

Integrating environmental and spatial processes in ecological community dynamics

Abstract: The processes controlling the abundances of species across multiple sites form the cornerstone of modern ecology. In these metacommunities, the relative importance of local environmental and regional spatial processes is currently hotly debated, especially in terms of the validity of neutral model. I collected 158 published data sets with information on community structure, environmental and spatial variables. I showed that approximately 50% of the variation in community composition is explained by both environmental and spatial variables. The majority of the data sets were structured by species-sorting dynamics (SS), followed by a combination of SS and mass-effect dynamics. While neutral processes were the only structuring process in 8% of the collected natural communities, disregarding neutral dispersal processes would result in missing important patterns in 37% of the studied communities. Moreover, metacommunity characteristics such as dispersal type, habitat type and spatial scale predicted part of the detected variation in metacommunity structure.

Nonlinear Dynamics and Chaos

Abstract: Nonlinear dynamics deals with more-or-less regular fluctuations in system variables caused by feedback intrinsic to the system (as opposed to external forces). Chaos is the most exotic form of nonlinear dynamics, in which deterministic interactions produce apparently irregular fluctuations, and small changes in the initial state of the system are magnified through time.7 Keywords: chaos; population cycles; population dynamics; nonlinear time-series analysis