Institution
University of California, Santa Cruz
Education•Santa Cruz, California, United States•
About: University of California, Santa Cruz is a education organization based out in Santa Cruz, California, United States. It is known for research contribution in the topics: Galaxy & Population. The organization has 15541 authors who have published 44120 publications receiving 2759983 citations. The organization is also known as: UCSC & UC, Santa Cruz.
Topics: Galaxy, Population, Star formation, Redshift, Planet
Papers published on a yearly basis
Papers
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TL;DR: In this paper, a method of functionally classifying genes by using gene expression data from DNA microarray hybridization experiments is introduced based on the theory of support vector machines (SVMs).
Abstract: We introduce a method of functionally classifying genes by using gene expression data from DNA microarray hybridization experiments. The method is based on the theory of support vector machines (SVMs). SVMs are considered a supervised computer learning method because they exploit prior knowledge of gene function to identify unknown genes of similar function from expression data. SVMs avoid several problems associated with unsupervised clustering methods, such as hierarchical clustering and self-organizing maps. SVMs have many mathematical features that make them attractive for gene expression analysis, including their flexibility in choosing a similarity function, sparseness of solution when dealing with large data sets, the ability to handle large feature spaces, and the ability to identify outliers. We test several SVMs that use different similarity metrics, as well as some other supervised learning methods, and find that the SVMs best identify sets of genes with a common function using expression data. Finally, we use SVMs to predict functional roles for uncharacterized yeast ORFs based on their expression data.
2,395 citations
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TL;DR: A closed quantum-mechanical system with a large number of degrees of freedom does not necessarily give time averages in agreement with the microcanonical distribution, so by adding a finite but very small perturbation in the form of a random matrix, the results of quantum statistical mechanics are recovered.
Abstract: A closed quantum-mechanical system with a large number of degrees of freedom does not necessarily give time averages in agreement with the microcanonical distribution. For systems where the different degrees of freedom are uncoupled, situations are discussed that show a violation of the usual statistical-mechanical rules. By adding a finite but very small perturbation in the form of a random matrix, it is shown that the results of quantum statistical mechanics are recovered. Expectation values in energy eigenstates for this perturbed system are also discussed, and deviations from the microcanonical result are shown to become exponentially small in the number of degrees of freedom.
2,390 citations
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TL;DR: In this paper, the authors studied the dark-matter halo density profiles in a high-resolution N-body simulation of a CDM cosmology and found that the redshift dependence of the median concentration is cvirRvir/rs.
Abstract: We study dark-matter halo density profiles in a high-resolution N-body simulation of aCDM cosmology. Our statistical sample contains �5000 haloes in the range 10 11 10 14 h −1 M⊙ and the resolution allows a study of subhaloes inside host haloes. The profiles are parameterized by an NFW form with two parameters, an inner radius rs and a virial radius Rvir, and we define the halo concentration cvirRvir/rs. We find that, for a given halo mass, the redshift dependence of the median concentration is cvir / (1 + z) −1 . This corresponds to rs(z) � constant, and is contrary to earlier suspicions that cvir does not vary much with redshift. The implications are that high- redshift galaxies are predicted to be more extended and dimmer than expected before. Second, we find that the scatter in halo profiles is large, with a 1� �(logcvir) = 0.18 at a given mass, corresponding to a scatter in maximum rotation velocities of �Vmax/Vmax = 0.12. We discuss implications for modelling the Tully-Fisher relation, which has a smaller reported intrinsic scatter. Third, subhaloes and haloes in dense environments tend to be more concentrated than isolated haloes, and show a larger scatter. These results suggest that cvir is an essential parameter for the theory of galaxy modelling, and we briefly discuss implications for the universality of the Tully- Fisher relation, the formation of low surface brightness galaxies, and the origin of the Hubble sequence. We present an improved analytic treatment of halo formation that fits the measured relations between halo parameters and their redshift dependence, and can thus serve semi-analytic studies of galaxy formation.
2,383 citations
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University of California, San Diego1, University of Montana2, Stanford University3, Scripps Institution of Oceanography4, National Autonomous University of Mexico5, Salk Institute for Biological Studies6, San Diego State University7, Strathclyde Institute of Pharmacy and Biomedical Sciences8, Lawrence Berkeley National Laboratory9, Harvard University10, University of Rennes11, University of Minnesota12, University of Lorraine13, Technical University of Denmark14, University of California, Los Angeles15, J. Craig Venter Institute16, University of Washington17, ETH Zurich18, University of Illinois at Chicago19, National Sun Yat-sen University20, Academia Sinica21, University of Münster22, Victoria University of Wellington23, University of North Carolina at Chapel Hill24, Indiana University25, Smithsonian Tropical Research Institute26, University of São Paulo27, Federal University of Mato Grosso do Sul28, University of Notre Dame29, University of California, Santa Cruz30, Oregon State University31, University of California, Berkeley32, Florida International University33, University of Hawaii at Manoa34, University of Geneva35, Institut de Chimie des Substances Naturelles36, Pacific Northwest National Laboratory37, National Institutes of Health38, Chinese Academy of Sciences39
TL;DR: In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations.
Abstract: The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.
2,365 citations
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TL;DR: Michael W. Beck, Kenneth L. Heck, Jr., Kenneth W. Heck's son, and Peter F. Sheridan are among the authors of this book, which aims to provide a history of web exceptionalism from 1989 to 2002.
Abstract: Michael W. Beck, Kenneth L. Heck, Jr., Kenneth W. Able, Daniel L. Childers, David B. Eggleston, Bronwyn M. Gillanders, Benjamin Halpern, Cynthia G. Hays, Kaho Hoshino, Thomas J. Minello, Robert J. Orth, Peter F. Sheridan and Michael P. Weinstein
2,356 citations
Authors
Showing all 15733 results
Name | H-index | Papers | Citations |
---|---|---|---|
David J. Schlegel | 193 | 600 | 193972 |
David R. Williams | 178 | 2034 | 138789 |
John R. Yates | 177 | 1036 | 129029 |
David Haussler | 172 | 488 | 224960 |
Evan E. Eichler | 170 | 567 | 150409 |
Anton M. Koekemoer | 168 | 1127 | 106796 |
Mark Gerstein | 168 | 751 | 149578 |
Alexander S. Szalay | 166 | 936 | 145745 |
Charles M. Lieber | 165 | 521 | 132811 |
Jorge E. Cortes | 163 | 2784 | 124154 |
M. Razzano | 155 | 515 | 106357 |
Lars Hernquist | 148 | 598 | 88554 |
Aaron Dominguez | 147 | 1968 | 113224 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Garth D. Illingworth | 137 | 505 | 61793 |