University of California, Santa Cruz

About: University of California, Santa Cruz is a education organization based out in Santa Cruz, California, United States. It is known for research contribution in the topics: Galaxy & Population. The organization has 15541 authors who have published 44120 publications receiving 2759983 citations. The organization is also known as: UCSC & UC, Santa Cruz.

Segregation of cognitive and motor aspects of visual function using induced motion

Abstract: Targets were displaced to cancel an apparent displacement induced by a step motion of a background or were held stationary while appearing to jump in an induced displacement. Target and background were then extinguished, and the subject pointed to the target’s last position. When the target had appeared to move but did not, background position did not significantly affect pointing; when the target had moved but appeared to remain stationary (displacement canceled by opposite induced displacement), pointing depended upon the target’s egocentric position. A similar result was obtained with sinusoidal motion. In terms of a two visual-systems hypothesis, the motor system uses more veridical spatial information and is less affected by relative changes in two retinal signals than is the cognitive system.

Forces Shaping the Fastest Evolving Regions in the Human Genome

Abstract: Comparative genomics allow us to search the human genome for segments that were extensively changed in the last approximately 5 million years since divergence from our common ancestor with chimpanzee, but are highly conserved in other species and thus are likely to be functional. We found 202 genomic elements that are highly conserved in vertebrates but show evidence of significantly accelerated substitution rates in human. These are mostly in non-coding DNA, often near genes associated with transcription and DNA binding. Resequencing confirmed that the five most accelerated elements are dramatically changed in human but not in other primates, with seven times more substitutions in human than in chimp. The accelerated elements, and in particular the top five, show a strong bias for adenine and thymine to guanine and cytosine nucleotide changes and are disproportionately located in high recombination and high guanine and cytosine content environments near telomeres, suggesting either biased gene conversion or isochore selection. In addition, there is some evidence of directional selection in the regions containing the two most accelerated regions. A combination of evolutionary forces has contributed to accelerated evolution of the fastest evolving elements in the human genome.

Size Evolution of the Most Massive Galaxies at 1.7 < z < 3 from GOODS NICMOS Survey Imaging

Abstract: We measure the sizes of 82 massive (M ≥ 1011 M☉) galaxies at 1.7 ≤ z ≤ 3 utilizing deep HST NICMOS data taken in the GOODS North and South fields. Our sample is almost an order of magnitude larger than previous studies at these redshifts, providing the first statistical study of massive galaxy sizes at z > 2, confirming the extreme compactness of these systems. We split our sample into disk-like (n ≤ 2) and spheroid-like (n > 2) galaxies based on their Sersic indices, and find that at a given stellar mass disk-like galaxies at z ~ 2.3 are a factor of 2.6 ± 0.3 smaller than present-day equal-mass systems, and spheroid-like galaxies at the same redshifts are 4.3 ± 0.7 smaller than comparatively massive elliptical galaxies today. At z > 2 our results are compatible with both a leveling off, or a mild evolution in size. Furthermore, the high density (~2 × 1010 M☉ kpc−3) of massive galaxies at these redshifts, which are similar to present-day globular clusters, possibly makes any further evolution in sizes beyond z = 3 unlikely.

The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

Abstract: Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of modern Eurasians and also appear to have been later introduced into Africans. Thus, adaptive introgression of archaic alleles has significantly shaped modern human immune systems.