Institution
University of California, Santa Cruz
Education•Santa Cruz, California, United States•
About: University of California, Santa Cruz is a education organization based out in Santa Cruz, California, United States. It is known for research contribution in the topics: Galaxy & Population. The organization has 15541 authors who have published 44120 publications receiving 2759983 citations. The organization is also known as: UCSC & UC, Santa Cruz.
Topics: Galaxy, Population, Star formation, Redshift, Planet
Papers published on a yearly basis
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TL;DR: In this paper, the existence of low-dimensional chaotic dynamical systems describing turbulent fluid flow was determined experimentally by reconstructing phase-space pictures from the observation of a single coordinate of any dissipative dynamical system and determining the dimensionality of the system's attractor.
Abstract: It is shown how the existence of low-dimensional chaotic dynamical systems describing turbulent fluid flow might be determined experimentally. Techniques are outlined for reconstructing phase-space pictures from the observation of a single coordinate of any dissipative dynamical system, and for determining the dimensionality of the system's attractor. These techniques are applied to a well-known simple three-dimensional chaotic dynamical system.
3,628 citations
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Memorial Sloan Kettering Cancer Center1, Broad Institute2, Heidelberg University3, University of São Paulo4, University of California, Santa Cruz5, Harvard University6, Institute for Systems Biology7, University of Texas MD Anderson Cancer Center8, Case Western Reserve University9, Henry Ford Health System10, Duke University11, Emory University12, University of California, San Francisco13, Cedars-Sinai Medical Center14, St. Joseph's Hospital and Medical Center15, University of Florida16, Thomas Jefferson University17, University of Toronto18, Christiana Care Health System19, Mayo Clinic20, Penrose Hospital21, University of Southern California22, University of North Carolina at Chapel Hill23, Baylor College of Medicine24, University of British Columbia25, Oregon Health & Science University26, Washington University in St. Louis27
TL;DR: Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM.
3,593 citations
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Carnegie Institution for Science1, California Institute of Technology2, Swinburne University of Technology3, Rutgers University4, Australian National University5, University of Arizona6, Johns Hopkins University7, Harvard University8, University of Cambridge9, University of California, Santa Cruz10, Herzberg Institute of Astrophysics11
TL;DR: In this paper, the final results of the Hubble Space Telescope (HST) Key Project to measure the Hubble constant are presented, and the results are based on a Cepheid calibration of several secondary distance methods applied over the range of about 60-400 Mpc.
Abstract: We present here the final results of the Hubble Space Telescope (HST) Key Project to measure the Hubble constant. We summarize our method, the results, and the uncertainties, tabulate our revised distances, and give the implications of these results for cosmology. Our results are based on a Cepheid calibration of several secondary distance methods applied over the range of about 60-400 Mpc. The analysis presented here benefits from a number of recent improvements and refinements, including (1) a larger LMC Cepheid sample to define the fiducial period-luminosity (PL) relations, (2) a more recent HST Wide Field and Planetary Camera 2 (WFPC2) photometric calibration, (3) a correction for Cepheid metallicity, and (4) a correction for incompleteness bias in the observed Cepheid PL samples. We adopt a distance modulus to the LMC (relative to which the more distant galaxies are measured) of μ0 = 18.50 ± 0.10 mag, or 50 kpc. New, revised distances are given for the 18 spiral galaxies for which Cepheids have been discovered as part of the Key Project, as well as for 13 additional galaxies with published Cepheid data. The new calibration results in a Cepheid distance to NGC 4258 in better agreement with the maser distance to this galaxy. Based on these revised Cepheid distances, we find values (in km s-1 Mpc-1) of H0 = 71 ± 2 ± 6 (systematic) (Type Ia supernovae), H0 = 71 ± 3 ± 7 (Tully-Fisher relation), H0 = 70 ± 5 ± 6 (surface brightness fluctuations), H0 = 72 ± 9 ± 7 (Type II supernovae), and H0 = 82 ± 6 ± 9 (fundamental plane). We combine these results for the different methods with three different weighting schemes, and find good agreement and consistency with H0 = 72 ± 8 km s-1 Mpc-1. Finally, we compare these results with other, global methods for measuring H0.
3,397 citations
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TL;DR: The sixth claim has received the least attention in the literature on embodied cognition, but it may in fact be the best documented and most powerful of the six claims.
Abstract: The emerging viewpoint of embodied cognition holds that cognitive processes are deeply rooted in the body’s interactions with the world. This position actually houses a number of distinct claims, some of which are more controversial than others. This paper distinguishes and evaluates the following six claims: (1) cognition is situated; (2) cognition is time-pressured; (3) we off-load cognitive work onto the environment; (4) the environment is part of the cognitive system; (5) cognition is for action; (6) offline cognition is body based. Of these, the first three and the fifth appear to be at least partially true, and their usefulness is best evaluated in terms of the range of their applicability. The fourth claim, I argue, is deeply problematic. The sixth claim has received the least attention in the literature on embodied cognition, but it may in fact be the best documented and most powerful of the six claims.
3,387 citations
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TL;DR: It is shown that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour.
Abstract: Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been specifically developed for its treatment. As part of The Cancer Genome Atlas, here we profile 178 lung squamous cell carcinomas to provide a comprehensive landscape of genomic and epigenomic alterations. We show that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour. We find statistically recurrent mutations in 11 genes, including mutation of TP53 in nearly all specimens. Previously unreported loss-of-function mutations are seen in the HLA-A class I major histocompatibility gene. Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes in 44%, phosphatidylinositol-3-OH kinase pathway genes in 47%, and CDKN2A and RB1 in 72% of tumours. We identified a potential therapeutic target in most tumours, offering new avenues of investigation for the treatment of squamous cell lung cancers.
3,356 citations
Authors
Showing all 15733 results
Name | H-index | Papers | Citations |
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David J. Schlegel | 193 | 600 | 193972 |
David R. Williams | 178 | 2034 | 138789 |
John R. Yates | 177 | 1036 | 129029 |
David Haussler | 172 | 488 | 224960 |
Evan E. Eichler | 170 | 567 | 150409 |
Anton M. Koekemoer | 168 | 1127 | 106796 |
Mark Gerstein | 168 | 751 | 149578 |
Alexander S. Szalay | 166 | 936 | 145745 |
Charles M. Lieber | 165 | 521 | 132811 |
Jorge E. Cortes | 163 | 2784 | 124154 |
M. Razzano | 155 | 515 | 106357 |
Lars Hernquist | 148 | 598 | 88554 |
Aaron Dominguez | 147 | 1968 | 113224 |
Taeghwan Hyeon | 139 | 563 | 75814 |
Garth D. Illingworth | 137 | 505 | 61793 |