Showing papers by "University of Cambridge published in 2004"
TL;DR: In this article, a new hybrid exchange-correlation functional named CAM-B3LYP is proposed, which combines the hybrid qualities of B3LYP and the long-range correction presented by Tawada et al.
10,882 citations
University of Leeds1, Royal Society for the Protection of Birds2, University of Cambridge3, Macquarie University4, Durham University5, University of the Witwatersrand6, Conservation International7, Stellenbosch University8, World Conservation Monitoring Centre9, National Autonomous University of Mexico10, University of Kansas11, James Cook University12
TL;DR: Estimates of extinction risks for sample regions that cover some 20% of the Earth's terrestrial surface show the importance of rapid implementation of technologies to decrease greenhouse gas emissions and strategies for carbon sequestration.
Abstract: Climate change over the past approximately 30 years has produced numerous shifts in the distributions and abundances of species and has been implicated in one species-level extinction. Using projections of species' distributions for future climate scenarios, we assess extinction risks for sample regions that cover some 20% of the Earth's terrestrial surface. Exploring three approaches in which the estimated probability of extinction shows a power-law relationship with geographical range size, we predict, on the basis of mid-range climate-warming scenarios for 2050, that 15-37% of species in our sample of regions and taxa will be 'committed to extinction'. When the average of the three methods and two dispersal scenarios is taken, minimal climate-warming scenarios produce lower projections of species committed to extinction ( approximately 18%) than mid-range ( approximately 24%) and maximum-change ( approximately 35%) scenarios. These estimates show the importance of rapid implementation of technologies to decrease greenhouse gas emissions and strategies for carbon sequestration.
7,089 citations
TL;DR: In this paper, the thermodynamic properties of 154 mineral endmembers, 13 silicate liquid end-members and 22 aqueous fluid species are presented in a revised and updated data set.
Abstract: The thermodynamic properties of 154 mineral end-members, 13 silicate liquid end-members and 22 aqueous fluid species are presented in a revised and updated data set. The use of a temperature-dependent thermal expansion and bulk modulus, and the use of high-pressure equations of state for solids and fluids, allows calculation of mineral–fluid equilibria to 100 kbar pressure or higher. A pressure-dependent Landau model for order–disorder permits extension of disordering transitions to high pressures, and, in particular, allows the alpha–beta quartz transition to be handled more satisfactorily. Several melt end-members have been included to enable calculation of simple phase equilibria and as a first stage in developing melt mixing models in NCKFMASH. The simple aqueous species density model has been extended to enable speciation calculations and mineral solubility determination involving minerals and aqueous species at high temperatures and pressures. The data set has also been improved by incorporation of many new phase equilibrium constraints, calorimetric studies and new measurements of molar volume, thermal expansion and compressibility. This has led to a significant improvement in the level of agreement with the available experimental phase equilibria, and to greater flexibility in calculation of complex mineral equilibria. It is also shown that there is very good agreement between the data set and the most recent available calorimetric data.
4,482 citations
Goddard Space Flight Center1, Brera Astronomical Observatory2, University of Milan3, University College London4, Pennsylvania State University5, University of Leicester6, Sonoma State University7, University of California, Berkeley8, Universities Space Research Association9, National Research Council10, University of Southampton11, Los Alamos National Laboratory12, National Radio Astronomy Observatory13, Space Telescope Science Institute14, Max Planck Society15, California Institute of Technology16, University of Texas at Austin17, French Alternative Energies and Atomic Energy Commission18, University of Toronto19, University of Maryland, College Park20, Princeton University21, Lawrence Livermore National Laboratory22, University of Cambridge23, University of California, Santa Barbara24, Rice University25, University of Tokyo26, Saitama University27, University of Florence28
TL;DR: The Swift mission as discussed by the authors is a multi-wavelength observatory for gamma-ray burst (GRB) astronomy, which is a first-of-its-kind autonomous rapid-slewing satellite for transient astronomy and pioneers the way for future rapid-reaction and multiwavelength missions.
Abstract: The Swift mission, scheduled for launch in 2004, is a multiwavelength observatory for gamma-ray burst (GRB) astronomy. It is a first-of-its-kind autonomous rapid-slewing satellite for transient astronomy and pioneers the way for future rapid-reaction and multiwavelength missions. It will be far more powerful than any previous GRB mission, observing more than 100 bursts yr � 1 and performing detailed X-ray and UV/optical afterglow observations spanning timescales from 1 minute to several days after the burst. The objectives are to (1) determine the origin of GRBs, (2) classify GRBs and search for new types, (3) study the interaction of the ultrarelativistic outflows of GRBs with their surrounding medium, and (4) use GRBs to study the early universe out to z >10. The mission is being developed by a NASA-led international collaboration. It will carry three instruments: a newgeneration wide-field gamma-ray (15‐150 keV) detector that will detect bursts, calculate 1 0 ‐4 0 positions, and trigger autonomous spacecraft slews; a narrow-field X-ray telescope that will give 5 00 positions and perform spectroscopy in the 0.2‐10 keV band; and a narrow-field UV/optical telescope that will operate in the 170‐ 600 nm band and provide 0B3 positions and optical finding charts. Redshift determinations will be made for most bursts. In addition to the primary GRB science, the mission will perform a hard X-ray survey to a sensitivity of � 1m crab (� 2;10 � 11 ergs cm � 2 s � 1 in the 15‐150 keV band), more than an order of magnitude better than HEAO 1 A-4. A flexible data and operations system will allow rapid follow-up observations of all types of
3,753 citations
Wellcome Trust1, University of Cambridge2, University of California, Berkeley3, Stanford University4, Princeton University5, Carnegie Institution for Science6, Northwestern University7, California Institute of Technology8, Wellcome Trust Sanger Institute9, Medical College of Wisconsin10, Cornell University11, Iowa State University12, Incyte13
TL;DR: The Gene Ontology (GO) project as discussed by the authors provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellular biology and are freely available for community use in the annotation of genes, gene products and sequences.
Abstract: The Gene Ontology (GO) project (http://www.geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellular biology and are freely available for community use in the annotation of genes, gene products and sequences. Many model organism databases and genome annotation groups use the GO and contribute their annotation sets to the GO resource. The GO database integrates the vocabularies and contributed annotations and provides full access to this information in several formats. Members of the GO Consortium continually work collectively, involving outside experts as needed, to expand and update the GO vocabularies. The GO Web resource also provides access to extensive documentation about the GO project and links to applications that use GO data for functional analyses.
3,565 citations
TL;DR: The EQ reveals both a sex difference in empathy in the general population and an empathy deficit in Asperger Syndrome or high-functioning autism adults, who are reported clinically to have difficulties in empathy.
Abstract: Empathy is an essential part of normal social functioning, yet there are precious few instruments for measuring individual differences in this domain. In this article we review psychological theories of empathy and its measurement. Previous instruments that purport to measure this have not always focused purely on empathy. We report a new self-report questionnaire, the Empathy Quotient (EQ), for use with adults of normal intelligence. It contains 40 empathy items and 20 filler/control items. On each empathy item a person can score 2, 1, or 0, so the EQ has a maximum score of 80 and a minimum of zero. In Study 1 we employed the EQ with n = 90 adults (65 males, 25 females) with Asperger Syndrome (AS) or high-functioning autism (HFA), who are reported clinically to have difficulties in empathy. The adults with AS/HFA scored significantly lower on the EQ than n = 90 (65 males, 25 females) age-matched controls. Of the adults with AS/HFA, 81% scored equal to or fewer than 30 points out of 80, compared with only 12% of controls. In Study 2 we carried out a study of n = 197 adults from a general population, to test for previously reported sex differences (female superiority) in empathy. This confirmed that women scored significantly higher than men. The EQ reveals both a sex difference in empathy in the general population and an empathy deficit in AS/HFA.
3,430 citations
TL;DR: Advances in human lesion-mapping support the functional localization of such inhibition to right IFC alone, and future research should investigate the generality of this proposed inhibitory function to other task domains, and its interaction within a wider network.
2,920 citations
TL;DR: The long-term stability of C-reactive protein values was similar to that of both blood pressure and total serum cholesterol, and recommendations regarding its use in predicting the likelihood of coronary heart disease may need to be reviewed.
Abstract: Background C-reactive protein is an inflammatory marker believed to be of value in the prediction of coronary events. We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease. Methods Measurements were made in samples obtained at base line from up to 2459 patients who had a nonfatal myocardial infarction or died of coronary heart disease during the study and from up to 3969 controls without a coronary heart disease event in the Reykjavik prospective study of 18,569 participants. Measurements were made in paired samples obtained an average of 12 years apart from 379 of these participants in order to quantify within-person fluctuations in inflammatory marker levels. Results The long-term stability of C-reactive protein values (within-person correlation coefficient, 0.59; 95 percent confidence interval, 0.52 to 0.66) was similar to that of both blood pressure an...
2,911 citations
TL;DR: Algorithms developed by the author for recognizing persons by their iris patterns have now been tested in many field and laboratory trials, producing no false matches in several million comparison tests.
Abstract: Algorithms developed by the author for recognizing persons by their iris patterns have now been tested in many field and laboratory trials, producing no false matches in several million comparison tests. The recognition principle is the failure of a test of statistical independence on iris phase structure encoded by multi-scale quadrature wavelets. The combinatorial complexity of this phase information across different persons spans about 249 degrees of freedom and generates a discrimination entropy of about 3.2 b/mm/sup 2/ over the iris, enabling real-time decisions about personal identity with extremely high confidence. The high confidence levels are important because they allow very large databases to be searched exhaustively (one-to-many "identification mode") without making false matches, despite so many chances. Biometrics that lack this property can only survive one-to-one ("verification") or few comparisons. The paper explains the iris recognition algorithms and presents results of 9.1 million comparisons among eye images from trials in Britain, the USA, Japan, and Korea.
2,829 citations
TL;DR: This work shows that mammalian target of rapamycin (mTOR) is sequestered in polyglutamine aggregates in cell models, transgenic mice and human brains, and provides proof-of-principle for the potential of inducing autophagy to treat Huntington disease.
Abstract: Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded polyglutamine proteins accumulate abnormally in intracellular aggregates. Here we show that mammalian target of rapamycin (mTOR) is sequestered in polyglutamine aggregates in cell models, transgenic mice and human brains. Sequestration of mTOR impairs its kinase activity and induces autophagy, a key clearance pathway for mutant huntingtin fragments. This protects against polyglutamine toxicity, as the specific mTOR inhibitor rapamycin attenuates huntingtin accumulation and cell death in cell models of Huntington disease, and inhibition of autophagy has the converse effects. Furthermore, rapamycin protects against neurodegeneration in a fly model of Huntington disease, and the rapamycin analog CCI-779 improved performance on four different behavioral tasks and decreased aggregate formation in a mouse model of Huntington disease. Our data provide proof-of-principle for the potential of inducing autophagy to treat Huntington disease.
2,335 citations
TL;DR: It is shown how to use resonant Raman spectroscopy to determine structure and composition of carbon films with and without nitrogen, and the assignment of the peaks at 1150 and 1480 cm−1 often observed in nanodiamond.
Abstract: Raman spectroscopy is a standard characterization technique for any carbon system. Here we review the Raman spectra of amorphous, nanostructured, diamond-like carbon and nanodiamond. We show how to use resonant Raman spectroscopy to determine structure and composition of carbon films with and without nitrogen. The measured spectra change with varying excitation energy. By visible and ultraviolet excitation measurements, the G peak dispersion can be derived and correlated with key parameters, such as density, sp(3) content, elastic constants and chemical composition. We then discuss the assignment of the peaks at 1150 and 1480 cm(-1) often observed in nanodiamond. We review the resonant Raman, isotope substitution and annealing experiments, which lead to the assignment of these peaks to trans-polyacetylene.
TL;DR: An overview of important topics and applications in the context of relaying covers different approaches to exploiting the benefits of multihop communications via relays, such as solutions for radio range extension in mobile and wireless broadband cellular networks and solutions to combat shadowing at high radio frequencies.
Abstract: In recent years, there has been an upsurge of interest in multihop-augmented infrastructure-based networks in both the industry and academia, such as the seed concept in 3GPP, mesh networks in IEEE 802.16, and converge extension of HiperLAN/2 through relays or user-cooperative diversity mesh networks. This article, a synopsis of numerous contributions to the working group 4 of the wireless world research forum and other research work, presents an overview of important topics and applications in the context of relaying. It covers different approaches to exploiting the benefits of multihop communications via relays, such as solutions for radio range extension in mobile and wireless broadband cellular networks (trading range for capacity), and solutions to combat shadowing at high radio frequencies. Furthermore, relaying is presented as a means to reduce infrastructure deployment costs. It is also shown that through the exploitation of spatial diversity, multihop relaying can enhance capacity in cellular networks. We wish to emphasize that while this article focuses on fixed relays, many of the concepts presented can also be applied to systems with moving relays.
TL;DR: It is argued that this framework helps to reconcile three perspectives on the efficacy of social capital, incorporating a broader reading of history, politics, and the empirical evidence regarding the mechanisms connecting types of network structure and state-society relations to public health outcomes.
Abstract: Three perspectives on the efficacy of social capital have been explored in the public health literature. A "social support" perspective argues that informal networks are central to objective and subjective welfare; an "inequality" thesis posits that widening economic disparities have eroded citizens' sense of social justice and inclusion, which in turn has led to heightened anxiety and compromised rising life expectancies; a "political economy" approach sees the primary determinant of poor health outcomes as the socially and politically mediated exclusion from material resources. A more comprehensive but grounded theory of social capital is presented that develops a distinction between bonding, bridging, and linking social capital. It is argued that this framework helps to reconcile these three perspectives, incorporating a broader reading of history, politics, and the empirical evidence regarding the mechanisms connecting types of network structure and state-society relations to public health outcomes.
TL;DR: In this paper, the use of the ratio of nebular lines of [O III] and [N II], first introduced by Alloin et al., is reappraised with modern calibration data and shown to have certain advantages over Ρ 23 ≡ ([On] + [OIII])/Hβ and N2 ≡ [N 2] λ6583/Hα, particularly when applied to star-forming galaxies at high redshifts.
Abstract: Among 'empirical' methods of estimating oxygen abundances in extragalactic H II regions, the use of the ratio of nebular lines of [O III] and [N II], first introduced by Alloin et al., is reappraised with modern calibration data and shown to have certain advantages over Ρ 23 ≡ ([On] + [O III])/Hβ and N2 ≡ [N II] λ6583/Hα, particularly when applied to star-forming galaxies at high redshifts.
TL;DR: A systematic review of research linking the networking behavior of firms with their innovative capacity is presented in this paper, where the authors find that the principal benefits of networking as identified in the literature include, risk sharing; obtaining access to new markets and technologies; speeding products to market; pooling complementary skills; safeguarding property rights when complete or contingent contracts are not possible.
Abstract: Porter and Ketels' (2003) study of British competitiveness emphasised the importance of business networking for innovativeness. Until recently insights into the dynamics of this relationship have been fragmented. This paper presents a systematic review of research linking the networking behaviour of firms with their innovative capacity. We find that the principal benefits of networking as identified in the literature include, risk sharing; obtaining access to new markets and technologies; speeding products to market; pooling complementary skills; safeguarding property rights when complete or contingent contracts are not possible; and acting as a key vehicle for obtaining access to external knowledge. The evidence also illustrates that those firms which do not cooperate and which do not formally or informally exchange knowledge limit their knowledge base on a long-term basis and ultimately reduce their ability to enter into exchange relationships. At an institutional level, national systems of innovation play an important role in the diffusion of innovations in terms of the way in which they shape networking activity. The paper provides evidence suggesting that network relationships with suppliers, customers, and intermediaries such as professional and trade associations are important factors affecting innovation performance and productivity. Where networks fail it is due to inter-firm conflict, displacement, lack of scale, external disruption and lack of infrastructure. The review identifies several gaps in the literature that need to be filled. For instance, there is a need for further exploration of the relationship between networking and different forms of innovation, such as, process and organisational innovation. Similarly, we need better understanding of network dynamics and network configurations, as well as the role of third parties such as professional and trade associations. Our study highlights the need for inter-disciplinary research in these areas.
University of California, Riverside1, University of Leeds2, University of Cambridge3, Max Planck Society4, National Institute of Standards and Technology5, Commonwealth Scientific and Industrial Research Organisation6, Imperial College London7, École Polytechnique Fédérale de Lausanne8, University of Göttingen9
TL;DR: In this article, the IUPAC Subcommittee on GasKinetic Data Evaluation for Atmospheric Chemistry presented the first in the series, presenting kinetic and photochemical data evaluated by the committee.
Abstract: . This article, the first in the series, presents kinetic and photochemical data evaluated by the IUPAC Subcommittee on GasKinetic Data Evaluation for Atmospheric Chemistry. It covers the gas phase and photochemical reactions of Ox, HOx, NOx and SOx species, which were last published in 1997, and were updated on the IUPAC website in late 2001. The article consists of a summary sheet, containing the recommended kinetic parameters for the evaluated reactions, and five appendices containing the data sheets, which provide information upon which the recommendations are made.
TL;DR: The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003 and offers a route to predicting the relative success of emerging strains.
Abstract: The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.
TL;DR: A fuller understanding of patterns of human plasticity in response to early nutrition and other environmental factors will have implications for the administration of public health.
Abstract: Many plants and animals are capable of developing in a variety of ways, forming characteristics that are well adapted to the environments in which they are likely to live. In adverse circumstances, for example, small size and slow metabolism can facilitate survival, whereas larger size and more rapid metabolism have advantages for reproductive success when resources are more abundant. Often these characteristics are induced in early life or are even set by cues to which their parents or grandparents were exposed. Individuals developmentally adapted to one environment may, however, be at risk when exposed to another when they are older. The biological evidence may be relevant to the understanding of human development and susceptibility to disease. As the nutritional state of many human mothers has improved around the world, the characteristics of their offspring--such as body size and metabolism--have also changed. Responsiveness to their mothers' condition before birth may generally prepare individuals so that they are best suited to the environment forecast by cues available in early life. Paradoxically, however, rapid improvements in nutrition and other environmental conditions may have damaging effects on the health of those people whose parents and grandparents lived in impoverished conditions. A fuller understanding of patterns of human plasticity in response to early nutrition and other environmental factors will have implications for the administration of public health.
TL;DR: In this paper, the authors examined the robustness of explanatory variables in cross-country economic growth regressions and employed a novel approach, Bayesian Averaging of Classical Estimates (BACE), which constructs estimates as a weighted average of OLS estimates for every possible combination of included variables.
Abstract: This paper examines the robustness of explanatory variables in cross-country economic growth regressions. It employs a novel approach, Bayesian Averaging of Classical Estimates (BACE), which constructs estimates as a weighted average of OLS estimates for every possible combination of included variables. The weights applied to individual regressions are justified on Bayesian grounds in a way similar to the well-known Schwarz criterion. Of 32 explanatory variables we find 11 to be robustly partially correlated with long-term growth and another five variables to be marginally related. Of all the variables considered, the strongest evidence is for the initial level of real GDP per capita.
TL;DR: Pulmonary arterial hypertension has a multifactorial pathobiology and recent genetic and pathophysiologic studies have emphasized the relevance of several mediators in this condition, including prostacyclin, nitric oxide, ET-1, angiopoietin- 1, serotonin, cytokines, chemokines, and members of the transforming-growth-factor-beta superfamily.
TL;DR: In this article, the choice of oxides, their structural and metallurgical behaviour, atomic diffusion, their deposition, interface structure and reactions, their electronic structure, bonding, band offsets, mobility degradation, flat band voltage shifts and electronic defects are discussed.
Abstract: The scaling of complementary metal oxide semiconductor (CMOS) transistors has led to the silicon dioxide layer used as a gate dielectric becoming so thin (1.4 nm) that its leakage current is too large. It is necessary to replace the SiO2 with a physically thicker layer of oxides of higher dielectric constant (κ) or 'high K' gate oxides such as hafnium oxide and hafnium silicate. Little was known about such oxides, and it was soon found that in many respects they have inferior electronic properties to SiO2 ,s uch as a tendency to crystallise and a high concentration of electronic defects. Intensive research is underway to develop these oxides into new high quality electronic materials. This review covers the choice of oxides, their structural and metallurgical behaviour, atomic diffusion, their deposition, interface structure and reactions, their electronic structure, bonding, band offsets, mobility degradation, flat band voltage shifts and electronic defects. The use of high K oxides in capacitors of dynamic random access memories is also covered.
TL;DR: This paper developed a discursive model of institutionalization that highlights the relationships among texts, discourse, institutions, and action, and proposed a set of conditions under which institutionalization processes are most likely to occur, and conclude the article with an exploration of the model's implications for other areas of research.
Abstract: We argue that the processes underlying institutionalization have not been investigated adequately and that discourse analysis provides a coherent framework for such investigation. Accordingly, we develop a discursive model of institutionalization that highlights the relationships among texts, discourse, institutions, and action. Based on this discursive model, we propose a set of conditions under which institutionalization processes are most likely to occur, and we conclude the article with an exploration of the model's implications for other areas of research.
TL;DR: In this article, a combination of approaches is required to estimate the major and trace element abundances in the depleted mantle (DM), the source for mid-ocean ridge basalts (MORBs).
Abstract: [1] We present an estimate for the composition of the depleted mantle (DM), the source for mid-ocean ridge basalts (MORBs). A combination of approaches is required to estimate the major and trace element abundances in DM. Absolute concentrations of few elements can be estimated directly, and the bulk of the estimates is derived using elemental ratios. The isotopic composition of MORB allows calculation of parent-daughter ratios. These estimates form the “backbone” of the abundances of the trace elements that make up the Coryell-Masuda diagram (spider diagram). The remaining elements of the Coryell-Masuda diagram are estimated through the composition of MORB. A third group of estimates is derived from the elemental and isotopic composition of peridotites. The major element composition is obtained by subtraction of a low-degree melt from a bulk silicate Earth (BSE) composition. The continental crust (CC) is thought to be complementary to the DM, and ratios that are chondritic in the CC are expected to also be chondritic in the DM. Thus some of the remaining elements are estimated using the composition of CC and chondrites. Volatile element and noble gas concentrations are estimated using constraints from the composition of MORBs and ocean island basalts (OIBs). Mass balance with BSE, CC, and DM indicates that CC and this estimate of the DM are not complementary reservoirs.
Bjerknes Centre for Climate Research1, Stockholm University2, Saint Petersburg State University3, Russian Academy of Sciences4, University of Cambridge5, Geological Museum6, Gas Technology Institute7, Lund University8, University of Copenhagen9, Alfred Wegener Institute for Polar and Marine Research10, University of Iceland11, University of New Hampshire12, Geological Survey of Sweden13, University of Oulu14, Aarhus University15, Ohio State University16, Geological Survey of Finland17, University of Bristol18, Leibniz Association19
TL;DR: In this paper, the maximum limits of the Eurasian ice sheets during four glaciations have been reconstructed: (1) the Late Saalian (>140 ka), (2) the Early Weichselian (100-80 ka),(3) the Middle Weichsellian (60-50 ka), and (4) the late Weichselsian (25-15 ka) based on satellite data and aerial photographs combined with geological field investigations in Russia and Siberia, and with marine seismic and sediment core data.
TL;DR: In this article, the authors used a rotating spindle to spin fibers and ribbons of carbon nanotubes directly from the chemical vapor deposition (CVD) synthesis zone of a furnace using a liquid source of carbon and an iron nanocatalyst.
Abstract: Many routes have been developed for the synthesis of carbon nanotubes, but their assembly into continuous fibers has been achieved only through postprocessing methods. We spun fibers and ribbons of carbon nanotubes directly from the chemical vapor deposition (CVD) synthesis zone of a furnace using a liquid source of carbon and an iron nanocatalyst. This process was realized through the appropriate choice of reactants, control of the reaction conditions, and continuous withdrawal of the product with a rotating spindle used in various geometries. This direct spinning from a CVD reaction zone is extendable to other types of fiber and to the spin coating of rotating objects in general.
TL;DR: Two studies show that negative feedback suppresses noise, and three others identify the sources of noise in gene expression, and a simple equation is presented that unifies and extends both the mathematical and biological perspectives.
Abstract: Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such 'noise' affects all life processes and has recently been measured using green fluorescent protein (GFP). Two studies show that negative feedback suppresses noise, and three others identify the sources of noise in gene expression. Here I critically analyse these studies and present a simple equation that unifies and extends both the mathematical and biological perspectives.
TL;DR: Advice on life-style modifications for all people with high blood pressure (BP) and those with borderline or high-normal BP is provided and there are compelling indications and contraindications for specific classes of antihypertensive drugs, and these are specified.
Abstract: Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IV
TL;DR: It is anticipated that a greater understanding of the prefrontal cortex will come from using tasks that load specific cognitive and executive processes, in parallel with discovering new ways of manipulating the different sub-regions and neuromodulatory systems of the cortex.
TL;DR: A phylodynamic framework for the dissection of dynamic forces that determine the diversity of epidemiological and phylogenetic patterns observed in RNA viruses of vertebrates is introduced.
Abstract: A key priority for infectious disease research is to clarify how pathogen genetic variation, modulated by host immunity, transmission bottlenecks, and epidemic dynamics, determines the wide variety of pathogen phylogenies observed at scales that range from individual host to population. We call the melding of immunodynamics, epidemiology, and evolutionary biology required to achieve this synthesis pathogen “phylodynamics.” We introduce a phylodynamic framework for the dissection of dynamic forces that determine the diversity of epidemiological and phylogenetic patterns observed in RNA viruses of vertebrates. A central pillar of this model is the Evolutionary Infectivity Profile, which captures the relationship between immune selection and pathogen transmission.
TL;DR: This tutorial review focuses on the living atom transfer radical polymerization (ATRP) system, and in this tutorial review a particular focus is given to examples of this technique.
Abstract: Polymer brushes produced by controlled surface-initiated polymerization provide a route to surfaces coated with well-defined thin polymer films that are covalently bound to the substrate. All of the major controlled polymerization techniques have been applied to the synthesis of polymer brushes and examples of each are presented here. Many examples of brush synthesis in the literature have used the living atom transfer radical polymerization (ATRP) system, and in this tutorial review a particular focus is given to examples of this technique.