Showing papers by "University of Coimbra published in 2019"
Umeå University1, Université Paris-Saclay2, Sheba Medical Center3, University of Rennes4, Utrecht University5, Charles University in Prague6, Hannover Medical School7, Royal Free Hospital8, Aberdeen Royal Infirmary9, University of Coimbra10, Queen Mary University of London11, Ludwig Maximilian University of Munich12, University of Eastern Piedmont13, Royal Free London NHS Foundation Trust14
TL;DR: These guidelines provide the most reliable contemporary evidence base for the management of RCC in 2019 and are thoroughly evaluated to establish international standards for the care of kidney cancer patients.
965 citations
TL;DR: This work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research, and an introduction to its chemistry.
Abstract: Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer’s disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin’s key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.
525 citations
TL;DR: The concentration of heavy metals in several sites, assessed in water, soil and sediment samples, affected by different pollution sources are reviewed, showing how human activities impact natural media and how the pollution spreads.
490 citations
TL;DR: This review gives an updated picture of each class of phenolic compounds and their properties and the use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.
Abstract: This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non-flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.
433 citations
Columbia University1, Stockholm University2, University of Bologna3, University of Mainz4, University of Münster5, University of Coimbra6, University of Turin7, New York University Abu Dhabi8, University of Zurich9, Rensselaer Polytechnic Institute10, University of Amsterdam11, Max Planck Society12, Weizmann Institute of Science13, University of Freiburg14, University of Nantes15, Purdue University16, University of California, San Diego17, University of Chicago18, Nagoya University19, Pierre-and-Marie-Curie University20, Université Paris-Saclay21, Rice University22, University of California, Los Angeles23
TL;DR: Constraints on light dark matter (DM) models using ionization signals in the XENON1T experiment are reported, and no DM or CEvNS detection may be claimed because the authors cannot model all of their backgrounds.
Abstract: We report constraints on light dark matter (DM) models using ionization signals in the XENON1T experiment. We mitigate backgrounds with strong event selections, rather than requiring a scintillation signal, leaving an effective exposure of (22±3) tonne day. Above ∼0.4 keVee, we observe 30 MeV/c2, and absorption of dark photons and axionlike particles for mχ within 0.186–1 keV/c2.
412 citations
TL;DR: In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided, and examples of the therapeutic approaches that have been developed to surpass theDrug resistance mechanisms exhibited by sp heroids are described.
Abstract: Three-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar to that displayed by human solid tumors. In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided. Furthermore, comparisons between the therapeutics resistance profile exhibited by spheroids, and 2D cell cultures are presented. Finally, examples of the therapeutic approaches that have been developed to surpass the drug resistance mechanisms exhibited by spheroids are described.
409 citations
TL;DR: The burden of serious health-related suffering will almost double by 2060, with the fastest increases occurring in low-income countries, among older people, and people with dementia.
334 citations
Harvard University1, Howard Hughes Medical Institute2, Broad Institute3, University of Zaragoza4, Max Planck Society5, University of Huddersfield6, University of Minho7, Pompeu Fabra University8, University of Vienna9, Pennsylvania State University10, University of Coimbra11, University of Zurich12, University of Granada13, University of the Basque Country14, Rovira i Virgili University15, National University of Distance Education16, University of Málaga17, University of Barcelona18, University of Valencia19, Autonomous University of Barcelona20, University of Lisbon21, Facultad de Filosofía y Letras22, University of Almería23, University of Cádiz24, University of Salamanca25, University of Iowa26, University of Las Palmas de Gran Canaria27, Mount Mercy University28, Autonomous University of Madrid29, Complutense University of Madrid30, University of Cantabria31, Liverpool John Moores University32, Gibraltar Hardware33, Anglia Ruskin University34, Spanish National Research Council35, University of California, Santa Barbara36, University of Basel37, Danube Private University38, University of Adelaide39
TL;DR: It is revealed that present-day Basques are best described as a typical Iron Age population without the admixture events that later affected the rest of Iberia, and how the ancestry of the peninsula was transformed by gene flow from North Africa and the eastern Mediterranean is document.
Abstract: J.M.F., F.J.L.-C., J.I.M., F.X.O., J.D., and M.S.B. were supported by HAR2017-86509-P, HAR2017-87695-P, and SGR2017-11 from the Generalitat de Catalunya, AGAUR agency. C.L.-F. was supported by Obra Social La Caixa and by FEDER-MINECO (BFU2015- 64699-P). L.B.d.L.E. was supported by REDISCO-HAR2017-88035-P (Plan Nacional I+D+I, MINECO). C.L., P.R., and C.Bl. were supported by MINECO (HAR2016-77600-P). A.Esp., J.V.-V., G.D., and D.C.S.-G. were supported by MINECO (HAR2009-10105 and HAR2013-43851-P). D.J.K. and B.J.C. were supported by NSF BCS-1460367. K.T.L., A.W., and J.M. were supported by NSF BCS-1153568. J.F.-E. and J.A.M.-A. were supported by IT622-13 Gobierno Vasco, Diputacion Foral de Alava, and Diputacion Foral de Gipuzkoa. We acknowledge support from the Portuguese Foundation for Science and Technology (PTDC/EPH-ARQ/4164/2014) and the FEDER-COMPETE 2020 project 016899. P.S. was supported by the FCT Investigator Program (IF/01641/2013), FCT IP, and ERDF (COMPETE2020 – POCI). M.Si. and K.D. were supported by a Leverhulme Trust Doctoral Scholarship awarded to M.B.R. and M.P. D.R. was supported by an Allen Discovery Center grant from the Paul Allen Foundation, NIH grant GM100233, and the Howard Hughes Medical Institute. V.V.-M. and W.H. were supported by the Max Planck Society.
287 citations
TL;DR: This review aims to bring together these multidisciplinary and interdisciplinary features of MDR cancers by deciphering the molecular mechanisms underlying anticancer drug resistance, to pave the way towards the development of novel precision medicine treatment modalities that are able to surmount distinct and well-defined mechanisms of antic cancer drug resistance.
281 citations
TL;DR: Preclinical and clinical data suggest that dietary polyphenols present prebiotic properties and exert antimicrobial activities against pathogenic GM, having benefits in distinct disorders, including obesity and diabetes.
Abstract: The human intestine contains an intricate ecological community of dwelling bacteria, referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, antibiotics, as well as environmental factors, particularly diet, thus causing a disruption of microbiota equilibrium (dysbiosis). Growing evidences support the involvement of GM dysbiosis in gastrointestinal (GI) and extra-intestinal cardiometabolic diseases, namely obesity and diabetes. This review firstly overviews the role of GM in health and disease, then critically reviews the evidences regarding the influence of dietary polyphenols in GM based on preclinical and clinical data, ending with strategies under development to improve efficiency of delivery. Although the precise mechanisms deserve further clarification, preclinical and clinical data suggest that dietary polyphenols present prebiotic properties and exert antimicrobial activities against pathogenic GM, having benefits in distinct disorders. Specifically, dietary polyphenols have been shown ability to modulate GM composition and function, interfering with bacterial quorum sensing, membrane permeability, as well as sensitizing bacteria to xenobiotics. In addition, can impact on gut metabolism and immunity and exert anti-inflammatory properties. In order to overcome the low bioavailability, several different approaches have been developed, aiming to improve solubility and transport of dietary polyphenols throughout the GI tract and deliver in the targeted intestinal regions. Although more research is still needed, particularly translational and clinical studies, the biotechnological progresses achieved during the last years open up good perspectives to, in a near future, be able to improve the use of dietary polyphenols modulating GM in a broad range of disorders characterized by a dysbiotic phenotype.
248 citations
Columbia University1, Stockholm University2, University of Bologna3, University of Mainz4, University of Münster5, University of Coimbra6, New York University Abu Dhabi7, University of Zurich8, Rensselaer Polytechnic Institute9, University of Amsterdam10, Max Planck Society11, Weizmann Institute of Science12, University of Freiburg13, University of Nantes14, University of California, San Diego15, University of Chicago16, Nagoya University17, Purdue University18, Pierre-and-Marie-Curie University19, Université Paris-Saclay20, Rice University21, University of California, Los Angeles22
TL;DR: The analysis uses the full ton year exposure of XENON1T to constrain the spin-dependent proton-only and neutron-only cases and sets exclusion limits on the WIMP-nucleon interactions.
Abstract: We report the first experimental results on spin-dependent elastic weakly interacting massive particle (WIMP) nucleon scattering from the XENON1T dark matter search experiment. The analysis uses the full ton year exposure of XENON1T to constrain the spin-dependent proton-only and neutron-only cases. No significant signal excess is observed, and a profile likelihood ratio analysis is used to set exclusion limits on the WIMP-nucleon interactions. This includes the most stringent constraint to date on the WIMP-neutron cross section, with a minimum of 6.3×10-42 cm2 at 30 GeV/c2 and 90% confidence level. The results are compared with those from collider searches and used to exclude new parameter space in an isoscalar theory with an axial-vector mediator.
TL;DR: An exclusion limit on the H→invisible branching ratio of 0.26(0.17_{-0.05}^{+0.07}) at 95% confidence level is observed (expected) in combination with the results at sqrt[s]=7 and 8 TeV.
Abstract: Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for H→invisible decays where H is produced according to the standard model via vector boson fusion, Z(ll)H, and W/Z(had)H, all performed with the ATLAS detector using 36.1 fb^{-1} of pp collisions at a center-of-mass energy of sqrt[s]=13 TeV at the LHC. In combination with the results at sqrt[s]=7 and 8 TeV, an exclusion limit on the H→invisible branching ratio of 0.26(0.17_{-0.05}^{+0.07}) at 95% confidence level is observed (expected).
TL;DR: In this article, an improved energy clustering algorithm is introduced, and its implications for the measurement and identification of prompt electrons and photons are discussed in detail, including corrections and calibrations that affect performance, including energy calibration, identification and isolation efficiencies.
Abstract: This paper describes the reconstruction of electrons and photons with the ATLAS detector, employed for measurements and searches exploiting the complete LHC Run 2 dataset. An improved energy clustering algorithm is introduced, and its implications for the measurement and identification of prompt electrons and photons are discussed in detail. Corrections and calibrations that affect performance, including energy calibration, identification and isolation efficiencies, and the measurement of the charge of reconstructed electron candidates are determined using up to 81 fb−1 of proton-proton collision data collected at √s=13 TeV between 2015 and 2017.
TL;DR: In this article, the ATLAS Collaboration during Run 2 of the Large Hadron Collider (LHC) was used to identify jets containing b-hadrons, and the performance of the algorithms was evaluated in the s...
Abstract: The algorithms used by the ATLAS Collaboration during Run 2 of the Large Hadron Collider to identify jets containing b-hadrons are presented. The performance of the algorithms is evaluated in the s ...
Wageningen University and Research Centre1, University of Plymouth2, University of Gothenburg3, University of Coimbra4, Katholieke Universiteit Leuven5, University of Groningen6, University of Exeter7, Newcastle University8, Brunel University London9, University of Ljubljana10, King's College London11, Stockholm University12, University of Tirana13, Cardiff University14, Free University of Berlin15, Utrecht University16, Czech University of Life Sciences Prague17, Norwegian University of Science and Technology18, University of Surrey19
TL;DR: The best available evidence suggests that microplastics and nanoplastics do not pose a widespread risk to humans or the environment, except in small pockets as discussed by the authors. But that evidence is limited, and the situation could change if pollution continues at the current rate.
Abstract: The best available evidence suggests that microplastics and nanoplastics do not pose a widespread risk to humans or the environment, except in small pockets. But that evidence is limited, and the situation could change if pollution continues at the current rate.
University of Texas at Austin1, Eötvös Loránd University2, American Institutes for Research3, Kwansei Gakuin University4, University of Coimbra5, University of Tehran6, East Tennessee State University7, University of Bern8, Universidade Federal do Rio Grande do Sul9, Université libre de Bruxelles10, Seoul Cyber University11, University of Sheffield12, University of Bergen13, University of Newcastle14, Birmingham City University15
TL;DR: Results support use of the SCS to examine 6 subscale scores or a total score, but not separate scores representing compassionate and uncompassionate self-responding, while fit was excellent using ESEM for the 6-factor correlated, single-bifactor and correlated 2- bifactor models.
Abstract: This study examined the factor structure of the Self-Compassion Scale (SCS) using secondary data drawn from 20 samples (N = 11,685)-7 English and 13 non-English-including 10 community, 6 student, 1 mixed community/student, 1 meditator, and 2 clinical samples. Self-compassion is theorized to represent a system with 6 constituent components: self-kindness, common humanity, mindfulness and reduced self-judgment, isolation and overidentification. There has been controversy as to whether a total score on the SCS or if separate scores representing compassionate versus uncompassionate self-responding should be used. The current study examined the factor structure of the SCS using confirmatory factor analyses (CFA) and Exploratory Structural Equation Modeling (ESEM) to examine 5 distinct models: 1-factor, 2-factor correlated, 6-factor correlated, single-bifactor (1 general self-compassion factor and 6 group factors), and 2-bifactor models (2 correlated general factors each with 3 group factors representing compassionate or uncompassionate self-responding). Results indicated that a 1- and 2-factor solution to the SCS had inadequate fit in every sample examined using both CFA and ESEM, whereas fit was excellent using ESEM for the 6-factor correlated, single-bifactor and correlated 2-bifactor models. However, factor loadings for the correlated 2-bifactor models indicated that 2 separate factors were not well specified. A general factor explained 95% of the reliable item variance in the single-bifactor model. Results support use of the SCS to examine 6 subscale scores (representing the constituent components of self-compassion) or a total score (representing overall self-compassion), but not separate scores representing compassionate and uncompassionate self-responding. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
TL;DR: The investigation of the mechanisms of cell death under the oxidative stress of PDT is of paramount importance to understand how the immune system is activated and, ultimately, to make PDT a more appealing/relevant therapeutic option.
Columbia University1, Stockholm University2, University of Bologna3, University of Mainz4, University of Münster5, University of Coimbra6, University of Turin7, New York University Abu Dhabi8, University of Zurich9, Rensselaer Polytechnic Institute10, University of Amsterdam11, Max Planck Society12, Weizmann Institute of Science13, University of Freiburg14, University of Nantes15, Purdue University16, University of California, San Diego17, University of Chicago18, Nagoya University19, Pierre-and-Marie-Curie University20, Université Paris-Saclay21, Rice University22, University of California, Los Angeles23
TL;DR: A probe of low-mass dark matter with masses down to about 85 MeV/c^{2} is reported on by looking for electronic recoils induced by the Migdal effect and bremsstrahlung using data from the XENON1T experiment, and exploiting an approach that uses ionization signals only allows for a lower detection threshold.
Abstract: Direct dark matter detection experiments based on a liquid xenon target are leading the search for dark matter particles with masses above ∼5 GeV/c2, but have limited sensitivity to lighter masses because of the small momentum transfer in dark matter-nucleus elastic scattering. However, there is an irreducible contribution from inelastic processes accompanying the elastic scattering, which leads to the excitation and ionization of the recoiling atom (the Migdal effect) or the emission of a bremsstrahlung photon. In this Letter, we report on a probe of low-mass dark matter with masses down to about 85 MeV/c2 by looking for electronic recoils induced by the Migdal effect and bremsstrahlung using data from the XENON1T experiment. Besides the approach of detecting both scintillation and ionization signals, we exploit an approach that uses ionization signals only, which allows for a lower detection threshold. This analysis significantly enhances the sensitivity of XENON1T to light dark matter previously beyond its reach.
TL;DR: In this paper, the decays of B0 s! + and B0! + have been studied using 26 : 3 fb of 13TeV LHC proton-proton collision data collected with the ATLAS detector in 2015 and 2016.
Abstract: A study of the decays B0 s ! + and B0 ! + has been performed using 26 : 3 fb of 13TeV LHC proton-proton collision data collected with the ATLAS detector in 2015 and 2016. Since the detector resolut ...
TL;DR: In this article, a review of the criteria applied to identify suitable technology-reservoir couples is presented, which is applicable to each of these reservoir types and technologies, determining the viability of the reservoir itself, and of the technology for that site.
Abstract: The increasing integration of renewable energies in the electricity grid is expected to contribute considerably towards the European Union goals of energy and GHG emissions reduction. However, it also brings new challenges for the grid. Large-scale energy storage can provide means for a better integration of renewable energy sources, balancing supply and demand, increasing energy security, enhancing a better management of the grid and also allowing convergence towards a low carbon economy. One way to ensure large-scale energy storage is to use the storage capacity in underground reservoirs, since geological formations have the potential to store large volumes of fluids with minimal impact to environment and society. There are several technologies which can be viable options for underground energy storage, as well as several types of underground reservoirs can be considered. The underground energy storage technologies for renewable energy integration addressed in this article are: Compressed Air Energy Storage (CAES); Underground Pumped Hydro Storage (UPHS); Underground Thermal Energy Storage (UTES); Underground Gas Storage (UGS) and Underground Hydrogen Storage (UHS), both connected to Power-to-gas (P2G) systems. For these different types of underground energy storage technologies there are several suitable geological reservoirs, namely: depleted hydrocarbon reservoirs, porous aquifers, salt formations, engineered rock caverns in host rocks and abandoned mines. Specific site screening criteria are applicable to each of these reservoir types and technologies, determining the viability of the reservoir itself, and of the technology for that site. This paper presents a review of the criteria applied to identify suitable technology-reservoir couples.
TL;DR: Oral treatment of APPswe/PS1dE9 mice with EGCG/AA NPs resulted in a marked increase in synapses, as judged by synaptophysin (SYP) expression, and reduction of neuroinflammation as well as amyloid &bgr; (A&b gr;) plaque burden and cortical levels of soluble and insoluble A&b Gr;(1‐42) peptide.
Charles University in Prague1, Academy of Sciences of the Czech Republic2, University of Coimbra3, Seoul National University4, Griffith University5, Pasteur Institute6, Centre national de la recherche scientifique7, Victor Chang Cardiac Research Institute8, University of New South Wales9, National Institutes of Health10, Radboud University Nijmegen11, Malaghan Institute of Medical Research12
TL;DR: It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents.
University of Waterloo1, Stellenbosch University2, Rhodes University3, University of Sydney4, University of Johannesburg5, University of Exeter6, Coventry University7, Pontifical Catholic University of Chile8, James Hutton Institute9, ETH Zurich10, University of Lausanne11, University of Coimbra12, Academy of Sciences of the Czech Republic13, Utrecht University14, University of Porto15
TL;DR: A synthesis of the key factors that influence people's perceptions of invasive alien species is produced, and six broad-scale dimensions are identified in a context of considerable complexity and variation across time and space.
TL;DR: In this review, an overview of the different chitosan-based asymmetric membranes developed for wound dressing applications is provided and the chitOSan modifications to enhance its bioactivity as well as the asymmetric membrane general properties and production techniques are described.
Université Paris-Saclay1, Queen Mary University of London2, Ludwig Maximilian University of Munich3, University of Rennes4, University Medical Center Utrecht5, Charles University in Prague6, Hannover Medical School7, Aberdeen Royal Infirmary8, Umeå University9, University of Coimbra10, University of Eastern Piedmont11, Sheba Medical Center12, Lund University13, Royal Free Hospital14, Netherlands Cancer Institute15, Royal Free London NHS Foundation Trust16
TL;DR: Pembrolizumab plus axitinib is a new standard of care for patients diagnosed with kidney cancer spread outside the kidney and who did not receive any prior treatment for their cancer (treatment naïve).
TL;DR: This study will help organizations to rethink their strategies according to skills development to respond to the challenges of digital transformation and will help individuals regarding the challenges faced by organizations and opportunities for new disruptive business.
TL;DR: There is need to better understand the rearing and farming procedures that will yield high quality edible insects in Africa, Asia and Europe.
Abstract: The traditional consumption of edible insects is common in one third of the world's population, mostly in Latin America, Africa and Asia. There are over one thousand identified species of insects eaten in some stage of their life cycle; and they play important roles in ensuring food security. The most common way to collect insects are from the wild, which is seasonal with limited availability and has an increasing demand resulting in a disruption to the ecosystem. There is a growing interest shown in rearing insects for commercial purposes, and an industrial scale production will be required to ensure steady supplies. Industrial production will need to take into account the living environment of insects, the nutritional composition of their feed and the overall efficiency of the production system. We provide a short overview on the consumption of and rearing insects in Africa, Asia and Europe. For Africa, a snapshot is given for Nigeria, Ghana, Central African Republic, Kenya and Uganda, while the following countries are reported for Asia: China, Japan, Lao People's Democratic Republic, Thailand and Vietnam. In addition, a list of insect species with the highest potential for food and feed in the European Union is provided with some reference to The Netherlands and Finland. The review concludes that there is need to better understand the rearing and farming procedures that will yield high quality edible insects in Africa, Asia and Europe.
TL;DR: In this article, a complete survey on scientific achievements related to silica aerogel composites reinforced with all types of fibres (natural, man-made, organic, inorganic and nanofibres), describing their synthesis approaches and properties is presented.
Abstract: Silica aerogels are among the lightest weight solid materials and exhibit other unique properties, in particular an outstanding insulation performance. However, these nanostructured highly porous materials show inherent brittleness that makes their processing and handling difficult and constrains their use in common daily applications. One of the most convincing and effective strategies to reinforce the silica aerogel structure is the manufacturing of aerogel composites with embedded fibres, which significantly contributes to widening their applications. This review encompasses a complete survey on scientific achievements related to silica aerogel composites reinforced with all types of fibres (natural, man-made, organic, inorganic and nanofibres), describing their synthesis approaches and properties. The influence of the embedment of different fibres on the final properties of the composites is thoroughly reported, considering their amount in the matrix and/or their specific characteristics, namely morphology, orientation and optical features. The applications linked to the fibre-reinforced silica aerogel composites are briefly addressed as well, evincing developments in typical functions of aerogels, as thermal and/or acoustic insulators and adsorbents, and also in emerging uses, for example as sensors or technical and protective apparel.
TL;DR: The properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields are discussed.
Abstract: The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer's properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.
TL;DR: The viability of chitosan-based nanocomposites films was found to be better than native chitOSan and PVA films and the adsorption property of prepared chito-based Nanocomposite films was tested for the removal of AB 1 dye.