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Institution

University of Coimbra

EducationCoimbra, Portugal
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.


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Journal ArticleDOI
TL;DR: This work documents 142 dams existing or under construction and 160 proposed dams for rivers draining the Andean headwaters of the Amazon, documenting losses in river connectivity that translate to drastic alteration of river channel and floodplain geomorphology and associated ecosystem services.
Abstract: Andes-to-Amazon river connectivity controls numerous natural and human systems in the greater Amazon. However, it is being rapidly altered by a wave of new hydropower development, the impacts of which have been previously underestimated. We document 142 dams existing or under construction and 160 proposed dams for rivers draining the Andean headwaters of the Amazon. Existing dams have fragmented the tributary networks of six of eight major Andean Amazon river basins. Proposed dams could result in significant losses in river connectivity in river mainstems of five of eight major systems—the Napo, Maranon, Ucayali, Beni, and Mamore. With a newly reported 671 freshwater fish species inhabiting the Andean headwaters of the Amazon (>500 m), dams threaten previously unrecognized biodiversity, particularly among endemic and migratory species. Because Andean rivers contribute most of the sediment in the mainstem Amazon, losses in river connectivity translate to drastic alteration of river channel and floodplain geomorphology and associated ecosystem services.

229 citations

Journal ArticleDOI
TL;DR: In vitro models, including non-cell based and cell-based models, and in vivo models are presented, with a particular emphasis on their methodological aspects and their contribution to the improvement of brain drug delivery strategies and drug transport across the blood-brain barrier is discussed.

229 citations

Journal ArticleDOI
Georges Aad1, S. Albrand2, J. S. Brown2, Johann Collot2, Sabine Crépé-Renaudin2, B. Dechenaux2, Pierre-Antoine Delsart2, C. Gabaldon2, Marie-Hélène Genest2, J-Y. Hostachy2, Fabienne Ledroit-Guillon2, Annick Lleres2, Arnaud Lucotte2, Fairouz Malek2, Caterina Monini2, Jan Stark2, Benjamin Trocmé2, M. Wu2, Ghita Rahal, Zuzana Barnovska3, Nicolas Berger3, Marco Delmastro3, L. Di Ciaccio3, T.K.O. Doan4, Sabine Elles3, Corinne Goy3, Tetiana Hryn'ova3, Stéphane Jézéquel3, H. Keoshkerian3, Iro Koletsou3, Remi Lafaye3, Jessica Levêque3, V.P. Lombardo5, N. Massol3, H. Przysiezniak3, G. Sauvage3, Emmanuel Sauvan3, M. Schwoerer3, Olivier Simard3, T. Todorov3, Isabelle Wingerter-Seez3, Lion Alio1, Marlon Barbero1, J. C. Clemens1, Yann Coadou1, Sara Diglio1, Fares Djama1, Lorenzo Feligioni1, Gregory David Hallewell1, Dieter H. H. Hoffmann1, Fabrice Hubaut1, Edith Knoops1, E. Le Guirriec1, Bing Li6, D. Madaffari1, K. Mochizuki1, Emmanuel Monnier1, G.S. Muanza7, Yoshikazu Nagai1, Pascal Pralavorio1, Alexandre Rozanov1, Thomas Serre1, Mossadek Talby1, E. Tiouchichine1, Sylvain Tisserant1, Jozsef Toth, Francois Touchard1, Michael Ughetto1, Laurent Vacavant1, M.K. Ayoub8, Ahmed Bassalat9, Cyril Becot9, Sebastien Binet9, Claire Bourdarios9, D. Delgove10, J-B. de Vivie De Regie11, Laurent Duflot9, Marc Escalier9, Louis Fayard9, Daniel Fournier9, Evangelos Leonidas Gkougkousis9, J-F Grivaz9, Thibault Guillemin9, F. Hariri9, Sophie Henrot-Versille9, Julius Hrivnac9, Lydia Iconomidou-Fayard9, Marumi Kado9, Abdenour Lounis9, Nikola Makovec9, Nicolas Morange12, Clara Nellist9, Pierre Petroff, Luc Poggioli9, Patrick Puzo9, A. Renaud9, David Rousseau9, Grigori Rybkin9, Arthur Schaffer9, Estelle Scifo9, Laurent Serin9, Stefan Simion9, Reisaburo Tanaka9, Dirk Zerwas9, Zhiqing Zhang9, Yongke Zhao13 
TL;DR: In this article, the authors reported the observation of Higgs boson decays to $WW^{\ast}$ based on an excess over background of 6.1 standard deviations, where the Standard Model expectation is 5.8 standard deviations.
Abstract: We report the observation of Higgs boson decays to $WW^{\ast}$ based on an excess over background of 6.1 standard deviations in the dilepton final state, where the Standard Model expectation is 5.8 standard deviations. Evidence for the vector-boson fusion (VBF) production process is obtained with a significance of 3.2 standard deviations. The results are obtained from a data sample corresponding to an integrated luminosity of $25 \textrm{pb}^{-1}$ from $\sqrt{s}=7$ and 8 TeV $pp$ collisions recorded by the ATLAS detector at the LHC. For a Higgs boson mass of 125.36 GeV, the ratio of the measured value to the expected value of the total production cross section times branching fraction is $1.09^{+0.16}_{-0.15} \textrm{(stat.)}^{+0.17}_{-0.14} \textrm{(syst.)}$. The corresponding ratios for the gluon fusion and vector-boson fusion production mechanisms are $1.02\pm 0.19 \textrm{(stat.)}^{+0.22}_{-0.18} \textrm{(syst.)}$ and $1.27^{+0.44}_{-0.40} \textrm{(stat.)}^{+0.30}_{-0.21} \textrm{(syst.)}$, respectively. At $\sqrt{s}=8$ TeV, the total production cross sections are measured to be $\sigma(gg\to H\rightarrow WW^\ast) = 4.6\pm0.9\,\textrm{(stat.)}\,^{+0.8}_{-0.7}\,\textrm{(syst.)}\textrm{pb}$ and $\sigma(\textrm{VBF} H\rightarrow WW^\ast) = 0.51\,^{+0.17}_{-0.15}\,\textrm{(stat.)}\,^{+0.13}_{-0.08}\,\textrm{(syst.)}\textrm{pb}$. The fiducial cross section is determined for the gluon-fusion process in exclusive final states with zero or one associated jet.

229 citations

Journal ArticleDOI
TL;DR: The data obtained show that the enhancement of AChE activity induced by Abeta(25-35) is mediated by oxidative stress, and that vitamin E and NOS inhibitors can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of AD patients.

228 citations

Journal ArticleDOI
TL;DR: This review covers some of the historical and recent advances of nanotechnology and concludes that polymeric nanoparticles show great promise as a tool for the development of peptide drug delivery systems.

228 citations


Authors

Showing all 14693 results

NameH-indexPapersCitations
P. Chang1702154151783
Yang Gao1682047146301
Bin Liu138218187085
P. Sinervo138151699215
Filipe Veloso12888775496
Panagiotis Kokkas128123481051
Nuno Filipe Castro12896076945
Robert Gardner128101577619
Francois Corriveau128102275729
Peter Krieger128117181368
João Carvalho126127877017
Helmut Wolters12685175721
Nicola Venturi12679669518
Sai-Juan Chen121121173991
Harinder Singh Bawa12079866120
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023112
2022530
20213,237
20203,193
20193,090