Institution
University of Coimbra
Education•Coimbra, Portugal•
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.
Papers published on a yearly basis
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Florida International University1, Duke University2, Columbia University3, Pontifical Xavierian University4, Universidad San Francisco de Quito5, University of Coimbra6, Central University of Ecuador7, National University of San Marcos8, Wildlife Conservation Society9, Francis Marion University10, Universidad Mayor11, Paul Sabatier University12
TL;DR: This work documents 142 dams existing or under construction and 160 proposed dams for rivers draining the Andean headwaters of the Amazon, documenting losses in river connectivity that translate to drastic alteration of river channel and floodplain geomorphology and associated ecosystem services.
Abstract: Andes-to-Amazon river connectivity controls numerous natural and human systems in the greater Amazon. However, it is being rapidly altered by a wave of new hydropower development, the impacts of which have been previously underestimated. We document 142 dams existing or under construction and 160 proposed dams for rivers draining the Andean headwaters of the Amazon. Existing dams have fragmented the tributary networks of six of eight major Andean Amazon river basins. Proposed dams could result in significant losses in river connectivity in river mainstems of five of eight major systems—the Napo, Maranon, Ucayali, Beni, and Mamore. With a newly reported 671 freshwater fish species inhabiting the Andean headwaters of the Amazon (>500 m), dams threaten previously unrecognized biodiversity, particularly among endemic and migratory species. Because Andean rivers contribute most of the sediment in the mainstem Amazon, losses in river connectivity translate to drastic alteration of river channel and floodplain geomorphology and associated ecosystem services.
229 citations
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TL;DR: In vitro models, including non-cell based and cell-based models, and in vivo models are presented, with a particular emphasis on their methodological aspects and their contribution to the improvement of brain drug delivery strategies and drug transport across the blood-brain barrier is discussed.
229 citations
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Aix-Marseille University1, University of Grenoble2, University of Savoy3, Joint Institute for Nuclear Research4, National University of La Plata5, University of Science and Technology of China6, University of Coimbra7, University of Milan8, University of Paris-Sud9, Dresden University of Technology10, Columbia University11, University of Iowa12, Shandong University13
TL;DR: In this article, the authors reported the observation of Higgs boson decays to $WW^{\ast}$ based on an excess over background of 6.1 standard deviations, where the Standard Model expectation is 5.8 standard deviations.
Abstract: We report the observation of Higgs boson decays to $WW^{\ast}$ based on an excess over background of 6.1 standard deviations in the dilepton final state, where the Standard Model expectation is 5.8 standard deviations. Evidence for the vector-boson fusion (VBF) production process is obtained with a significance of 3.2 standard deviations. The results are obtained from a data sample corresponding to an integrated luminosity of $25 \textrm{pb}^{-1}$ from $\sqrt{s}=7$ and 8 TeV $pp$ collisions recorded by the ATLAS detector at the LHC. For a Higgs boson mass of 125.36 GeV, the ratio of the measured value to the expected value of the total production cross section times branching fraction is $1.09^{+0.16}_{-0.15} \textrm{(stat.)}^{+0.17}_{-0.14} \textrm{(syst.)}$. The corresponding ratios for the gluon fusion and vector-boson fusion production mechanisms are $1.02\pm 0.19 \textrm{(stat.)}^{+0.22}_{-0.18} \textrm{(syst.)}$ and $1.27^{+0.44}_{-0.40} \textrm{(stat.)}^{+0.30}_{-0.21} \textrm{(syst.)}$, respectively. At $\sqrt{s}=8$ TeV, the total production cross sections are measured to be $\sigma(gg\to H\rightarrow WW^\ast) = 4.6\pm0.9\,\textrm{(stat.)}\,^{+0.8}_{-0.7}\,\textrm{(syst.)}\textrm{pb}$ and $\sigma(\textrm{VBF} H\rightarrow WW^\ast) = 0.51\,^{+0.17}_{-0.15}\,\textrm{(stat.)}\,^{+0.13}_{-0.08}\,\textrm{(syst.)}\textrm{pb}$. The fiducial cross section is determined for the gluon-fusion process in exclusive final states with zero or one associated jet.
229 citations
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TL;DR: The data obtained show that the enhancement of AChE activity induced by Abeta(25-35) is mediated by oxidative stress, and that vitamin E and NOS inhibitors can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of AD patients.
228 citations
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TL;DR: This review covers some of the historical and recent advances of nanotechnology and concludes that polymeric nanoparticles show great promise as a tool for the development of peptide drug delivery systems.
228 citations
Authors
Showing all 14693 results
Name | H-index | Papers | Citations |
---|---|---|---|
P. Chang | 170 | 2154 | 151783 |
Yang Gao | 168 | 2047 | 146301 |
Bin Liu | 138 | 2181 | 87085 |
P. Sinervo | 138 | 1516 | 99215 |
Filipe Veloso | 128 | 887 | 75496 |
Panagiotis Kokkas | 128 | 1234 | 81051 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Robert Gardner | 128 | 1015 | 77619 |
Francois Corriveau | 128 | 1022 | 75729 |
Peter Krieger | 128 | 1171 | 81368 |
João Carvalho | 126 | 1278 | 77017 |
Helmut Wolters | 126 | 851 | 75721 |
Nicola Venturi | 126 | 796 | 69518 |
Sai-Juan Chen | 121 | 1211 | 73991 |
Harinder Singh Bawa | 120 | 798 | 66120 |