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Institution

University of Coimbra

EducationCoimbra, Portugal
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.


Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, the authors showed that C dots can be electrostatically coated with cationic polymers, changing their surface charge and enabling them to escape from endosomes and enter the cytoplasm and nucleus.

198 citations

Journal ArticleDOI
TL;DR: In this paper, the primal-dual interior-point filter is used to solve the problem of global convergence to first-order critical points in nonlinear nonlinear programs, without the use of merit functions and penalty parameters.
Abstract: In this paper, the filter technique of Fletcher and Leyffer (1997) is used to globalize the primal-dual interior-point algorithm for nonlinear programming, avoiding the use of merit functions and the updating of penalty parameters.The new algorithm decomposes the primal-dual step obtained from the perturbed first-order necessary conditions into a normal and a tangential step, whose sizes are controlled by a trust-region type parameter. Each entry in the filter is a pair of coordinates: one resulting from feasibility and centrality, and associated with the normal step; the other resulting from optimality (complementarity and duality), and related with the tangential step.Global convergence to first-order critical points is proved for the new primal-dual interior-point filter algorithm.

198 citations

Journal ArticleDOI
TL;DR: Results indicate that A(2A) receptors in the striatum are not enriched in synapses in agreement with the preponderant role of A(3)H]SCH 58261 receptors in signal processing in striatopallidal neurons, in contrast, hippocampal A(1) receptors are enriched in Synaptosomal in accordance with their role in controlling neurotransmitter release.

198 citations

Journal ArticleDOI
TL;DR: Data is presented supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease and the mechanisms of nucleic acid oxidation and repair are outlined.

198 citations

Proceedings ArticleDOI
09 May 1999
TL;DR: In this paper, a new approach, based on the average motor supply current Park's vector monitoring, was introduced for diagnosing voltage source inverter faults in variable speed AC drives.
Abstract: This paper introduces a new approach, based on the average motor supply current Park's vector monitoring, for diagnosing voltage source inverter faults in variable speed AC drives. Both simulation and laboratory tests results demonstrate the effectiveness of the proposed on-line diagnostic technique.

198 citations


Authors

Showing all 14693 results

NameH-indexPapersCitations
P. Chang1702154151783
Yang Gao1682047146301
Bin Liu138218187085
P. Sinervo138151699215
Filipe Veloso12888775496
Panagiotis Kokkas128123481051
Nuno Filipe Castro12896076945
Robert Gardner128101577619
Francois Corriveau128102275729
Peter Krieger128117181368
João Carvalho126127877017
Helmut Wolters12685175721
Nicola Venturi12679669518
Sai-Juan Chen121121173991
Harinder Singh Bawa12079866120
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023112
2022530
20213,237
20203,193
20193,090