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Institution

University of Coimbra

EducationCoimbra, Portugal
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.


Papers
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Journal ArticleDOI
TL;DR: A systematic review of published articles on match analysis in adult male football, identify and organize common research topics, and synthesize the emerging patterns of work between 2012 and 2016 according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines are conducted.
Abstract: Evolving patterns of match analysis research need to be systematically reviewed regularly since this area of work is burgeoning rapidly and studies can offer new insights to performance analysts if theoretically and coherently organized. The purpose of this paper was to conduct a systematic review of published articles on match analysis in adult male football, identify and organize common research topics, and synthesize the emerging patterns of work between 2012 and 2016, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The Web of Science database was searched for relevant published studies using the following keywords: ‘football’ and ‘soccer’, each one associated with the terms ‘match analysis’, ‘performance analysis’, ‘notational analysis’, ‘game analysis’, ‘tactical analysis’ and ‘patterns of play’. Of 483 studies initially identified, 77 were fully reviewed and their outcome measures extracted and analyzed. Results showed that research mainly focused on (1) performance at set pieces, i.e. corner kicks, free kicks, penalty kicks; (2) collective system behaviours, captured by established variables such as team centroid (geometrical centre of a set of players) and team dispersion (quantification of how far players are apart), as well as tendencies for team communication (establishing networks based on passing sequences), sequential patterns (predicting future passing sequences), and group outcomes (relationships between match-related statistics and final match scores); and (3) activity profile of players, i.e. playing roles, effects of fatigue, substitutions during matches, and the effects of environmental constraints on performance, such as heat and altitude. From the previous review, novel variables were identified that require new measurement techniques. It is evident that the complexity engendered during performance in competitive soccer requires an integrated approach that considers multiple aspects. A challenge for researchers is to align these new measures with the needs of the coaches through a more integrated relationship between coaches and researchers, to produce practical and usable information that improves player performance and coach activity.

189 citations

Book ChapterDOI
25 Jun 2013
TL;DR: BLAKE2 is presented, an improved version of the SHA-3 finalist BLAKE optimized for speed in software, and provides a comprehensive support for tree-hashing as well as keyed hashing (be it in sequential or tree mode).
Abstract: We present the hash function BLAKE2, an improved version of the SHA-3 finalist BLAKE optimized for speed in software. Target applications include cloud storage, intrusion detection, or version control systems. BLAKE2 comes in two main flavors: BLAKE2b is optimized for 64-bit platforms, and BLAKE2s for smaller architectures. On 64-bit platforms, BLAKE2 is often faster than MD5, yet provides security similar to that of SHA-3: up to 256-bit collision resistance, immunity to length extension, indifferentiability from a random oracle, etc. We specify parallel versions BLAKE2bp and BLAKE2sp that are up to 4 and 8 times faster, by taking advantage of SIMD and/or multiple cores. BLAKE2 reduces the RAM requirements of BLAKE down to 168 bytes, making it smaller than any of the five SHA-3 finalists, and 32% smaller than BLAKE. Finally, BLAKE2 provides a comprehensive support for tree-hashing as well as keyed hashing (be it in sequential or tree mode).

189 citations

Journal ArticleDOI
15 Feb 2017-eLife
TL;DR: Results show that intact mitochondria with their mtDNA payload are transferred in the developing tumour, and provide functional evidence for an essential role of oxidative phosphorylation in cancer.
Abstract: Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ0 cells) is linked to the acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To determine whether the transfer of mtDNA involves whole mitochondria, we injected B16ρ0 mouse melanoma cells into syngeneic C57BL/6Nsu9-DsRed2 mice that express red fluorescent protein in their mitochondria. We document that mtDNA is acquired by transfer of whole mitochondria from the host animal, leading to normalisation of mitochondrial respiration. Additionally, knockdown of key mitochondrial complex I (NDUFV1) and complex II (SDHC) subunits by shRNA in B16ρ0 cells abolished or significantly retarded their ability to form tumours. Collectively, these results show that intact mitochondria with their mtDNA payload are transferred in the developing tumour, and provide functional evidence for an essential role of oxidative phosphorylation in cancer.

189 citations

Journal ArticleDOI
TL;DR: The most abundant natural flavonoids, their structure and chemical characteristics, extraction methods, and biological activity are presented in this article, with a focus on increasing the extraction yield and being environmentally friendly.
Abstract: In recent years, more attention has been paid to natural sources of antioxidants. Flavonoids are natural substances synthesized in several parts of plants that exhibit a high antioxidant capacity. They are a large family, presenting several classes based on their basic structure. Flavonoids have the ability to control the accumulation of reactive oxygen species (ROS) via scavenger ROS when they are formed. Therefore, these antioxidant compounds have an important role in plant stress tolerance and a high relevance in human health, mainly due to their anti-inflammatory and antimicrobial properties. In addition, flavonoids have several applications in the food industry as preservatives, pigments, and antioxidants, as well as in other industries such as cosmetics and pharmaceuticals. However, flavonoids application for industrial purposes implies extraction processes with high purity and quality. Several methodologies have been developed aimed at increasing flavonoid extraction yield and being environmentally friendly. This review presents the most abundant natural flavonoids, their structure and chemical characteristics, extraction methods, and biological activity.

188 citations

Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, Ovsat Abdinov4  +2908 moreInstitutions (209)
TL;DR: In this article, both resonant and nonresonant Higgs boson pair production were performed in the hh -> bb tau tau, gamma gamma WW* final states using 20.3 fb(-1) of collision data at a center-of-m...
Abstract: Searches for both resonant and nonresonant Higgs boson pair production are performed in the hh -> bb tau tau, gamma gamma WW* final states using 20.3 fb(-1) of pp collision data at a center-of-m ...

188 citations


Authors

Showing all 14693 results

NameH-indexPapersCitations
P. Chang1702154151783
Yang Gao1682047146301
Bin Liu138218187085
P. Sinervo138151699215
Filipe Veloso12888775496
Panagiotis Kokkas128123481051
Nuno Filipe Castro12896076945
Robert Gardner128101577619
Francois Corriveau128102275729
Peter Krieger128117181368
João Carvalho126127877017
Helmut Wolters12685175721
Nicola Venturi12679669518
Sai-Juan Chen121121173991
Harinder Singh Bawa12079866120
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023112
2022530
20213,237
20203,193
20193,090