scispace - formally typeset
Search or ask a question
Institution

University of Coimbra

EducationCoimbra, Portugal
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.


Papers
More filters
Journal ArticleDOI
TL;DR: In this article, the authors make use of existing multi-wavelength data including recently available far-IR continuum and mm spectral line (H2O Southern Galactic Plane Survey and Millimetre Astronomy Legacy Team 90 GHz Survey) data and present new, deep, multiple-filter, near-IR (Very Large Telescope/NACO) observations to study G0.253 + 0.016.
Abstract: Young massive clusters (YMCs) with stellar masses of 104-105 M ☉ and core stellar densities of 104-105 stars per cubic pc are thought to be the "missing link" between open clusters and extreme extragalactic super star clusters and globular clusters. As such, studying the initial conditions of YMCs offers an opportunity to test cluster formation models across the full cluster mass range. G0.253 + 0.016 is an excellent candidate YMC progenitor. We make use of existing multi-wavelength data including recently available far-IR continuum (Herschel/Herschel Infrared Galactic Plane Survey) and mm spectral line (H2O Southern Galactic Plane Survey and Millimetre Astronomy Legacy Team 90 GHz Survey) data and present new, deep, multiple-filter, near-IR (Very Large Telescope/NACO) observations to study G0.253 + 0.016. These data show that G0.253 + 0.016 is a high-mass (1.3 × 105 M ☉), low-temperature (T dust ~ 20 K), high-volume, and column density (n ~ 8 × 104 cm–3;NH2 ~ 4 × 10 23 cm–2) molecular clump which is close to virial equilibrium (M dust ~ M virial) so is likely to be gravitationally bound. It is almost devoid of star formation and, thus, has exactly the properties expected for the initial conditions of a clump that may form an Arches-like massive cluster. We compare the properties of G0.253 + 0.016 to typical Galactic cluster-forming molecular clumps and find it is extreme, and possibly unique in the Galaxy. This uniqueness makes detailed studies of G0.253 + 0.016 extremely important for testing massive cluster formation models.

185 citations

Journal ArticleDOI
TL;DR: A biodegradable drug delivery system that accelerated healing processes due to the combined effects of lactate and LL37 released from the nanoparticles is developed.

184 citations

Journal ArticleDOI
TL;DR: This study aimed to evaluate the efficacy of photodynamic therapy (PDT) in treating chronic central serous chorioretinopathy (CSC) and found it to be effective in treating CSC.
Abstract: Purpose: This study aimed to evaluate the efficacy of photodynamic therapy (PDT) in treating chronic central serous chorioretinopathy (CSC) Methods: We describe a non-randomized, multicentre, interventional case series A total of 82 eyes of 72 patients with chronic CSC were treated by conventional PDT LogMAR best corrected visual acuity (BCVA) (ETDRS charts) and central foveal thickness (CFT) measured by optical coherence tomography before and after PDT, number of PDT treatments and complications were used as outcome indicators Results: Mean follow-up was 12 ± 10 months and mean age was 46 ± 10 years Mean logMAR BCVA changed from 053 (standard deviation [SD] 043) before PDT to 038 (SD 041) at 3 months and 048 (SD 050) at 6 months (p < 00001 and p = 0007, respectively, Student's t-test for paired data) Mean BCVA at the end of follow-up was 037 (SD 045; p < 00001 from baseline) Macular detachment was resolved and subretinal fluid (SRF) disappeared in all cases Central foveal thickness decreased from 325 μm (SD 95), to 229 μm (SD 70) at 1 month after PDT, 206 μm (SD 68) at 3 months, and 202 μm (SD 76) at 6 months (all p < 00001, Student's t-test for paired data) No cases developed severe visual loss or complications derived from PDT Reactive retinal pigment epithelium hypertrophy appeared in nine cases after PDT Conclusions: Photodynamic therapy with verteporfin may be useful in chronic CSC for improving BCVA and reducing SRF and CFT Randomized studies with longer follow-up are needed to assess the real role of this treatment in chronic CSC © 2009 Acta Ophthalmol

184 citations

Journal ArticleDOI
TL;DR: In this article, the authors analyzed the concept of skills and also investigated the skills needed to create and manage disruptive digital business which is emerging from the IT evolution, and made a proposal of a model of skills development for managers of the disruptive business.

184 citations

Journal ArticleDOI
Elena Aprile1, Jelle Aalbers2, F. Agostini3, M. Alfonsi4, L. Althueser5, F. D. Amaro6, V. C. Antochi2, E. Angelino7, F. Arneodo8, D. Barge2, Laura Baudis9, Boris Bauermeister2, L. Bellagamba3, M. L. Benabderrahmane8, T. Berger10, P. A. Breur11, April S. Brown9, Ethan Brown10, S. Bruenner12, Giacomo Bruno8, Ran Budnik13, C. Capelli9, João Cardoso6, D. Cichon12, D. Coderre14, Auke-Pieter Colijn11, Jan Conrad2, Jean-Pierre Cussonneau15, M. P. Decowski11, P. de Perio1, A. Depoian16, P. Di Gangi3, A. Di Giovanni8, Sara Diglio15, A. Elykov14, G. Eurin12, J. Fei17, A. D. Ferella2, A. Fieguth5, W. Fulgione7, P. Gaemers11, A. Gallo Rosso, Michelle Galloway9, F. Gao1, M. Garbini3, L. Grandi18, Z. Greene1, C. Hasterok12, C. Hils4, E. Hogenbirk11, J. Howlett1, M. Iacovacci, R. Itay13, F. Joerg12, Shingo Kazama19, A. Kish9, M. Kobayashi1, G. Koltman13, A. Kopec16, H. Landsman13, R. F. Lang16, L. Levinson13, Qing Lin1, Sebastian Lindemann14, Manfred Lindner12, F. Lombardi6, J. A. M. Lopes6, E. López Fune20, C. Macolino21, Jörn Mahlstedt2, M. Manenti8, A. Manfredini9, A. Manfredini13, Fabrizio Marignetti, T. Marrodán Undagoitia12, Julien Masbou15, S. Mastroianni, M. Messina8, K. Micheneau15, Kate C. Miller18, A. Molinario, K. Morå2, Y. Mosbacher13, M. Murra5, J. Naganoma, Kaixuan Ni17, Uwe Oberlack4, K. Odgers10, J. Palacio15, Bart Pelssers2, R. Peres9, J. Pienaar18, V. Pizzella12, Guillaume Plante1, R. Podviianiuk, J. Qin16, H. Qiu13, D. Ramírez García14, S. Reichard9, B. Riedel18, A. Rocchetti14, N. Rupp12, J.M.F. dos Santos6, Gabriella Sartorelli3, N. Šarčević14, M. Scheibelhut4, S. Schindler4, J. Schreiner12, D. Schulte5, Marc Schumann14, L. Scotto Lavina20, M. Selvi3, P. Shagin22, E. Shockley18, Manuel Gameiro da Silva6, H. Simgen12, C. Therreau15, Dominique Thers15, F. Toschi14, Gian Carlo Trinchero7, C. Tunnell22, N. Upole18, M. Vargas5, G. Volta9, O. Wack12, Hongwei Wang23, Yuehuan Wei17, Ch. Weinheimer5, D. Wenz4, C. Wittweg5, J. Wulf9, J. Ye17, Yanxi Zhang1, T. Zhu1, J. P. Zopounidis20 
TL;DR: A probe of low-mass dark matter with masses down to about 85 MeV/c^{2} is reported on by looking for electronic recoils induced by the Migdal effect and bremsstrahlung using data from the XENON1T experiment, and exploiting an approach that uses ionization signals only allows for a lower detection threshold.
Abstract: Direct dark matter detection experiments based on a liquid xenon target are leading the search for dark matter particles with masses above ∼5 GeV/c2, but have limited sensitivity to lighter masses because of the small momentum transfer in dark matter-nucleus elastic scattering. However, there is an irreducible contribution from inelastic processes accompanying the elastic scattering, which leads to the excitation and ionization of the recoiling atom (the Migdal effect) or the emission of a bremsstrahlung photon. In this Letter, we report on a probe of low-mass dark matter with masses down to about 85 MeV/c2 by looking for electronic recoils induced by the Migdal effect and bremsstrahlung using data from the XENON1T experiment. Besides the approach of detecting both scintillation and ionization signals, we exploit an approach that uses ionization signals only, which allows for a lower detection threshold. This analysis significantly enhances the sensitivity of XENON1T to light dark matter previously beyond its reach.

184 citations


Authors

Showing all 14693 results

NameH-indexPapersCitations
P. Chang1702154151783
Yang Gao1682047146301
Bin Liu138218187085
P. Sinervo138151699215
Filipe Veloso12888775496
Panagiotis Kokkas128123481051
Nuno Filipe Castro12896076945
Robert Gardner128101577619
Francois Corriveau128102275729
Peter Krieger128117181368
João Carvalho126127877017
Helmut Wolters12685175721
Nicola Venturi12679669518
Sai-Juan Chen121121173991
Harinder Singh Bawa12079866120
Network Information
Related Institutions (5)
University of Antwerp
48.8K papers, 1.6M citations

92% related

University of Pisa
73.1K papers, 2.1M citations

91% related

Sapienza University of Rome
155.4K papers, 4.3M citations

91% related

University of Padua
114.8K papers, 3.6M citations

91% related

University of Münster
69K papers, 2.2M citations

91% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023112
2022530
20213,237
20203,193
20193,090