Institution
University of Coimbra
Education•Coimbra, Portugal•
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that oxidative stress is one of the earliest pathological changes in the brain of Alzheimer disease patients and plays a critical role in the vascular abnormalities underlying metabolic defects in Alzheimer disease.
176 citations
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TL;DR: In this paper, the production of W bosons in association with two jets in proton-proton collisions at a center-of-mass energy of root s = 7 TeV has been analyzed for the presence of double-parton interactions using data corresponding to an integrated luminosity of 36 pb(-1), collected with the ATLAS detector at the Large Hadron Collider.
Abstract: The production of W bosons in association with two jets in proton-proton collisions at a centre-of-mass energy of root s = 7 TeV has been analysed for the presence of double-parton interactions using data corresponding to an integrated luminosity of 36 pb(-1), collected with the ATLAS detector at the Large Hadron Collider. The fraction of events arising from double-parton interactions, f(DP)((D)), has been measured through the p(T) balance between the two jets and amounts to f(DP)((D)) = 0.08 +/- 0.01 (stat.) +/- 0.02 (sys.) for jets with transverse momentum p(T) > 20 GeV and rapidity vertical bar y vertical bar < 2.8. This corresponds to a measurement of the effective area parameter for hard double-parton interactions of sigma(eff) = 15 +/- 3 (stat.)(-3)(+5) (sys.) mb.
175 citations
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Academy of Sciences of the Czech Republic1, Charles University in Prague2, University of Coimbra3, Seoul National University4, Griffith University5, Pasteur Institute6, Centre national de la recherche scientifique7, University of New South Wales8, Victor Chang Cardiac Research Institute9, National Institutes of Health10, Radboud University Nijmegen11, Malaghan Institute of Medical Research12
TL;DR: It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents.
175 citations
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TL;DR: In this paper, the authors proposed the use of a Geographic Information System (GIS) to identify the best plots suitable for installing photovoltaic solar farms in the Municipality of Torre Pacheco, in the southeast of Spain.
175 citations
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TL;DR: The data suggest mitochondria are important in oxidative damage that occurs in AD and antioxidant therapies based on lipoic acid and N-acetyl cysteine supplementation may be promising.
Abstract: In this study, we evaluated the effect of lipoic acid (LA) and N-acetyl cysteine (NAC) on oxidative [4-hydroxy-2-nonenal, N(epsilon)-(carboxymethyl)lysine and heme oxygenase-1] and apoptotic (caspase 9 and Bax) markers in fibroblasts from patients with Alzheimer disease (AD) and age-matched and young controls. AD fibroblasts showed the highest levels of oxidative stress, and the antioxidants, lipoic acid (1 mM) and/or N-acetyl cysteine (100 microM) exerted a protective effect as evidenced by decreases in oxidative stress and apoptotic markers. Furthermore, we observed that the protective effect of LA and NAC was more pronounced when both agents were present simultaneously. AD-type changes could be generated in control fibroblasts using N-methylprotoporphyrin to inhibit cytochrome oxidase assembly indicating that the the oxidative damage observed was associated with mitochondrial dysfunction. The effects of N-methylprotoporphyrine were reversed or attenuated by both lipoic acid and N-acetyl cysteine. These data suggest mitochondria are important in oxidative damage that occurs in AD. As such, antioxidant therapies based on lipoic acid and N-acetyl cysteine supplementation may be promising.
175 citations
Authors
Showing all 14693 results
Name | H-index | Papers | Citations |
---|---|---|---|
P. Chang | 170 | 2154 | 151783 |
Yang Gao | 168 | 2047 | 146301 |
Bin Liu | 138 | 2181 | 87085 |
P. Sinervo | 138 | 1516 | 99215 |
Filipe Veloso | 128 | 887 | 75496 |
Panagiotis Kokkas | 128 | 1234 | 81051 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Robert Gardner | 128 | 1015 | 77619 |
Francois Corriveau | 128 | 1022 | 75729 |
Peter Krieger | 128 | 1171 | 81368 |
João Carvalho | 126 | 1278 | 77017 |
Helmut Wolters | 126 | 851 | 75721 |
Nicola Venturi | 126 | 796 | 69518 |
Sai-Juan Chen | 121 | 1211 | 73991 |
Harinder Singh Bawa | 120 | 798 | 66120 |