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Institution

University of Coimbra

EducationCoimbra, Portugal
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.


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Journal ArticleDOI
D. S. Akerib1, S. Alsum2, Henrique Araujo3, X. Bai4, A. J. Bailey3, J. Balajthy5, P. Beltrame, Ethan Bernard6, A. Bernstein7, T. P. Biesiadzinski1, E. M. Boulton6, R. Bramante1, P. Brás8, D. Byram9, Sidney Cahn10, M. C. Carmona-Benitez11, C. Chan12, A.A. Chiller9, C. Chiller9, A. Currie3, J. E. Cutter13, T. J. R. Davison, A. Dobi14, J. E. Y. Dobson15, E. Druszkiewicz16, B. N. Edwards10, C. H. Faham14, S. Fiorucci12, R. J. Gaitskell12, V. M. Gehman14, C. Ghag15, K.R. Gibson1, M. G. D. Gilchriese14, C. R. Hall5, M. Hanhardt4, S. J. Haselschwardt11, S. A. Hertel6, D. P. Hogan6, M. Horn6, D. Q. Huang12, C. M. Ignarra17, M. Ihm6, R.G. Jacobsen6, W. Ji1, K. Kamdin6, K. Kazkaz7, D. Khaitan16, R. Knoche5, N.A. Larsen10, C. Lee1, B. G. Lenardo7, K. T. Lesko14, A. Lindote8, M.I. Lopes8, A. Manalaysay13, R. L. Mannino18, M. F. Marzioni, Daniel McKinsey6, D. M. Mei9, J. Mock19, M. Moongweluwan16, J. A. Morad13, A. St. J. Murphy20, C. Nehrkorn11, H. N. Nelson11, F. Neves8, K. O’Sullivan6, K. C. Oliver-Mallory6, K. J. Palladino17, E. K. Pease6, P. Phelps1, L. Reichhart15, C. Rhyne12, S. Shaw15, T. A. Shutt1, C. Silva8, M. Solmaz11, V. N. Solovov8, P. Sorensen14, S. Stephenson13, T. J. Sumner3, Matthew Szydagis19, D. J. Taylor, W. C. Taylor12, B. P. Tennyson10, P. A. Terman18, D. R. Tiedt4, W. H. To1, Mani Tripathi13, L. Tvrznikova6, S. Uvarov13, J.R. Verbus12, R. C. Webb18, J. T. White18, T. J. Whitis1, M. S. Witherell14, F.L.H. Wolfs16, Jilei Xu7, K. Yazdani3, Sarah Young19, Chao Zhang9 
TL;DR: This search yields no evidence of WIMP nuclear recoils and constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4} kg day exposure of the Large Underground Xenon experiment are reported.
Abstract: We report constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4} kg day exposure of the Large Underground Xenon (LUX) experiment. A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead, South Dakota (USA). With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results, this search yields no evidence of WIMP nuclear recoils. At a WIMP mass of 50 GeV c^{-2}, WIMP-nucleon spin-independent cross sections above 2.2×10^{-46} cm^{2} are excluded at the 90% confidence level. When combined with the previously reported LUX exposure, this exclusion strengthens to 1.1×10^{-46} cm^{2} at 50 GeV c^{-2}.

1,844 citations

Journal ArticleDOI
Elena Aprile1, Jelle Aalbers2, F. Agostini3, M. Alfonsi4, L. Althueser5, F. D. Amaro6, M. Anthony1, F. Arneodo7, Laura Baudis8, Boris Bauermeister9, M. L. Benabderrahmane7, T. Berger10, P. A. Breur2, April S. Brown2, Ethan Brown10, S. Bruenner11, Giacomo Bruno7, Ran Budnik12, C. Capelli8, João Cardoso6, D. Cichon11, D. Coderre13, Auke-Pieter Colijn2, Jan Conrad9, Jean-Pierre Cussonneau14, M. P. Decowski2, P. de Perio1, P. Di Gangi3, A. Di Giovanni7, Sara Diglio14, A. Elykov13, G. Eurin11, J. Fei15, A. D. Ferella9, A. Fieguth5, W. Fulgione, A. Gallo Rosso, Michelle Galloway8, F. Gao1, M. Garbini3, C. Geis4, L. Grandi16, Z. Greene1, H. Qiu12, C. Hasterok11, E. Hogenbirk2, J. Howlett1, R. Itay12, F. Joerg11, B. Kaminsky13, Shingo Kazama8, A. Kish8, G. Koltman12, H. Landsman12, R. F. Lang17, L. Levinson12, Qing Lin1, Sebastian Lindemann13, Manfred Lindner11, F. Lombardi15, J. A. M. Lopes6, J. Mahlstedt9, A. Manfredini12, T. Marrodán Undagoitia11, Julien Masbou14, D. Masson17, M. Messina7, K. Micheneau14, Kate C. Miller16, A. Molinario, K. Morå9, M. Murra5, J. Naganoma18, Kaixuan Ni15, Uwe Oberlack4, Bart Pelssers9, F. Piastra8, J. Pienaar16, V. Pizzella11, Guillaume Plante1, R. Podviianiuk, N. Priel12, D. Ramírez García13, L. Rauch11, S. Reichard8, C. Reuter17, B. Riedel16, A. Rizzo1, A. Rocchetti13, N. Rupp11, J.M.F. dos Santos6, Gabriella Sartorelli3, M. Scheibelhut4, S. Schindler4, J. Schreiner11, D. Schulte5, Marc Schumann13, L. Scotto Lavina19, M. Selvi3, P. Shagin18, E. Shockley16, Manuel Gameiro da Silva6, H. Simgen11, Dominique Thers14, F. Toschi13, F. Toschi3, Gian Carlo Trinchero, C. Tunnell16, N. Upole16, M. Vargas5, O. Wack11, Hongwei Wang20, Zirui Wang, Yuehuan Wei15, Ch. Weinheimer5, C. Wittweg5, J. Wulf8, J. Ye15, Yanxi Zhang1, T. Zhu1 
TL;DR: In this article, a search for weakly interacting massive particles (WIMPs) using 278.8 days of data collected with the XENON1T experiment at LNGS is reported.
Abstract: We report on a search for weakly interacting massive particles (WIMPs) using 278.8 days of data collected with the XENON1T experiment at LNGS. XENON1T utilizes a liquid xenon time projection chamber with a fiducial mass of (1.30±0.01) ton, resulting in a 1.0 ton yr exposure. The energy region of interest, [1.4,10.6] keVee ([4.9,40.9] keVnr), exhibits an ultralow electron recoil background rate of [82-3+5(syst)±3(stat)] events/(ton yr keVee). No significant excess over background is found, and a profile likelihood analysis parametrized in spatial and energy dimensions excludes new parameter space for the WIMP-nucleon spin-independent elastic scatter cross section for WIMP masses above 6 GeV/c2, with a minimum of 4.1×10-47 cm2 at 30 GeV/c2 and a 90% confidence level.

1,808 citations

Journal ArticleDOI
TL;DR: It is demonstrated that an unequivocal role for common genetic variants in the etiology of typical PD and population-specific genetic heterogeneity in this disease is suggested, and supporting evidence that common variation around LRRK2 modulates risk for PD is provided.
Abstract: We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the gene encoding a-synuclein (SNCA; rs2736990, OR = 1.23, P = 2.24 x 10(-16)) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 x 10(-16)). We exchanged data with colleagues performing a GWAS in Japanese PD cases. Association to PD at SNCA was replicated in the Japanese GWAS1, confirming this as a major risk locus across populations. We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 x 10(-8)) and provide supporting evidence that common variation around LRRK2 modulates risk for PD (rs1491923, OR = 1.14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease.

1,793 citations

Journal ArticleDOI
TL;DR: Adding docetaxel to CF significantly improved TTP, survival, and response rate in gastric cancer patients, but resulted in some increase in toxicity.
Abstract: Purpose In the randomized, multinational phase II/III trial (V325) of untreated advanced gastric cancer patients, the phase II part selected docetaxel, cisplatin, and fluorouracil (DCF) over docetaxel and cisplatin for comparison against cisplatin and fluorouracil (CF; reference regimen) in the phase III part. Patients and Methods Advanced gastric cancer patients were randomly assigned to docetaxel 75 mg/m2 and cisplatin 75 mg/m2 (day 1) plus fluorouracil 750 mg/m2/d (days 1 to 5) every 3 weeks or cisplatin 100 mg/m2 (day 1) plus fluorouracil 1,000 mg/m2/d (days 1 to 5) every 4 weeks. The primary end point was time-to-progression (TTP). Results In 445 randomly assigned and treated patients (DCF = 221; CF = 224), TTP was longer with DCF versus CF (32% risk reduction; log-rank P < .001). Overall survival was longer with DCF versus CF (23% risk reduction; log-rank P = .02). Two-year survival rate was 18% with DCF and 9% with CF. Overall response rate was higher with DCF (χ2 P = .01). Grade 3 to 4 treatment-r...

1,731 citations

Journal ArticleDOI
TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.
Abstract: Background Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patients with Parkinson's disease. Methods Sixteen centers participated in our international, collaborative study: five from the Americas, six from Europe, two from Israel, and three from Asia. Each center genotyped a standard DNA panel to permit comparison of the genotyping results across centers. Genotypes and phenotypic data from a total of 5691 patients with Parkinson's disease (780 Ashkenazi Jews) and 4898 controls (387 Ashkenazi Jews) were analyzed, with multivariate logistic-regression models and the Mantel–Haenszel procedure used to estimate odds ratios across centers. Results All 16 centers could detect two GBA mutations, L444P and N370S. Among Ashkenazi Jewish subjects, either mutation was found in 15% of p...

1,629 citations


Authors

Showing all 14693 results

NameH-indexPapersCitations
P. Chang1702154151783
Yang Gao1682047146301
Bin Liu138218187085
P. Sinervo138151699215
Filipe Veloso12888775496
Panagiotis Kokkas128123481051
Nuno Filipe Castro12896076945
Robert Gardner128101577619
Francois Corriveau128102275729
Peter Krieger128117181368
João Carvalho126127877017
Helmut Wolters12685175721
Nicola Venturi12679669518
Sai-Juan Chen121121173991
Harinder Singh Bawa12079866120
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023112
2022530
20213,237
20203,193
20193,090