Institution
University of Coimbra
Education•Coimbra, Portugal•
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.
Papers published on a yearly basis
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TL;DR: This review aims to bring together these multidisciplinary and interdisciplinary features of MDR cancers by deciphering the molecular mechanisms underlying anticancer drug resistance, to pave the way towards the development of novel precision medicine treatment modalities that are able to surmount distinct and well-defined mechanisms of antic cancer drug resistance.
281 citations
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01 Jan 2013TL;DR: General concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes) are described.
Abstract: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.
281 citations
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Spanish National Research Council1, James Cook University2, Swiss Federal Institute of Aquatic Science and Technology3, ETH Zurich4, University of Tasmania5, University of Coimbra6, University of Hong Kong7, University of New England (Australia)8, Universidade Federal de Minas Gerais9, Ecolab10, University of Toulouse11, University of Toronto12, National University of Comahue13, Monash University14, University of Concepción15, Cornell University16, University of Puerto Rico17, University of Yamanashi18, Egerton University19, University of Panama20, Instituto Conmemorativo Gorgas de Estudios de la Salud21
TL;DR: It is found that climate warming will likely hasten microbial litter decomposition and produce an equivalent decline in detritivore-mediated decomposition rates, which implies consequences for global biogeochemistry and a possible positive climate feedback.
Abstract: The decomposition of plant litter is one of the most important ecosystem processes in the biosphere and is particularly sensitive to climate warming. Aquatic ecosystems are well suited to studying warming effects on decomposition because the otherwise confounding influence of moisture is constant. By using a latitudinal temperature gradient in an unprecedented global experiment in streams, we found that climate warming will likely hasten microbial litter decomposition and produce an equivalent decline in detritivore-mediated decomposition rates. As a result, overall decomposition rates should remain unchanged. Nevertheless, the process would be profoundly altered, because the shift in importance from detritivores to microbes in warm climates would likely increase CO2 production and decrease the generation and sequestration of recalcitrant organic particles. In view of recent estimates showing that inland waters are a significant component of the global carbon cycle, this implies consequences for global biogeochemistry and a possible positive climate feedback.
280 citations
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Institut national de la recherche agronomique1, Agro ParisTech2, Oeschger Centre for Climate Change Research3, Université du Québec à Chicoutimi4, Chinese Academy of Sciences5, University of Zaragoza6, University of Coimbra7, Mendel University8, Spanish National Research Council9, Sukachev Institute of Forest10, Siberian Federal University11, University of Ljubljana12, University of Innsbruck13, Charles University in Prague14, Queen's University15
TL;DR: High-resolution cellular based measurements of wood formation dynamics in three coniferous forest sites in northeastern France are presented and it is suggested that forecasted changes in the annual cycle of climatic factors may shift the phase timing of stem size increase and woody biomass production in the future.
Abstract: Wood is the main terrestrial biotic reservoir for long-term carbon sequestration(1), and its formation in trees consumes around 15% of anthropogenic carbon dioxide emissions each year(2). However, the seasonal dynamics of woody biomass production cannot be quantified from eddy covariance or satellite observations. As such, our understanding of this key carbon cycle component, and its sensitivity to climate, remains limited. Here, we present high-resolution cellular based measurements of wood formation dynamics in three coniferous forest sites in northeastern France, performed over a period of 3 years. We show that stem woody biomass production lags behind stem-girth increase by over 1 month. We also analyse more general phenological observations of xylem tissue formation in Northern Hemisphere forests and find similar time lags in boreal, temperate, subalpine and Mediterranean forests. These time lags question the extension of the equivalence between stem size increase and woody biomass production to intra-annual time scales(3, 4, 5, 6). They also suggest that these two growth processes exhibit differential sensitivities to local environmental conditions. Indeed, in the well-watered French sites the seasonal dynamics of stem-girth increase matched the photoperiod cycle, whereas those of woody biomass production closely followed the seasonal course of temperature. We suggest that forecasted changes in the annual cycle of climatic factors(7) may shift the phase timing of stem size increase and woody biomass production in the future.
280 citations
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Maastricht University1, Heidelberg University2, University of Erlangen-Nuremberg3, University of Göttingen4, University of Bonn5, Charité6, University of Genoa7, University of Geneva8, University of Cologne9, Aix-Marseille University10, VU University Amsterdam11, King's College London12, University of Eastern Finland13, Medical University of Łódź14, University of Perugia15, Aristotle University of Thessaloniki16, French Institute of Health and Medical Research17, University of Oxford18, University of Brescia19, University of Liège20, University of Gothenburg21, University of Lisbon22, University of Coimbra23, University of Antwerp24, Karolinska University Hospital25, Lund University26, Pierre-and-Marie-Curie University27, VU University Medical Center28
TL;DR: The use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage and the use of both amyloid and neuronal injury markers as proposed by the National Institute of Ageing-Alzheimer Association criteria offers the most accurate prognosis are supported.
Abstract: Three sets of research criteria are available for diagnosis of Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, International Working Group-2, and National Institute of Aging-Alzheimer Association criteria. We compared the prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage according to these criteria. Subjects with mild cognitive impairment (n = 1607), 766 of whom had both amyloid and neuronal injury markers, were recruited from 13 cohorts. We used cognitive test performance and available biomarkers to classify subjects as prodromal Alzheimer's disease according to International Working Group-1 and International Working Group-2 criteria and in the high Alzheimer's disease likelihood group, conflicting biomarker groups (isolated amyloid pathology or suspected non-Alzheimer pathophysiology), and low Alzheimer's disease likelihood group according to the National Institute of Ageing-Alzheimer Association criteria. Outcome measures were the proportion of subjects with Alzheimer's disease at the mild cognitive impairment stage and progression to Alzheimer's disease-type dementia. We performed survival analyses using Cox proportional hazards models. According to the International Working Group-1 criteria, 850 (53%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 50% compared to 21% for subjects without prodromal Alzheimer's disease. According to the International Working Group-2 criteria, 308 (40%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 61% compared to 22% for subjects without prodromal Alzheimer's disease. According to the National Institute of Ageing-Alzheimer Association criteria, 353 (46%) subjects were in the high Alzheimer's disease likelihood group, 49 (6%) in the isolated amyloid pathology group, 220 (29%) in the suspected non-Alzheimer pathophysiology group, and 144 (19%) in the low Alzheimer's disease likelihood group. The 3-year progression rate to Alzheimer's disease-type dementia was 59% in the high Alzheimer's disease likelihood group, 22% in the isolated amyloid pathology group, 24% in the suspected non-Alzheimer pathophysiology group, and 5% in the low Alzheimer's disease likelihood group. Our findings support the use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage. In clinical settings, the use of both amyloid and neuronal injury markers as proposed by the National Institute of Ageing-Alzheimer Association criteria offers the most accurate prognosis. For clinical trials, selection of subjects in the National Institute of Ageing-Alzheimer Association high Alzheimer's disease likelihood group or the International Working Group-2 prodromal Alzheimer's disease group could be considered.
279 citations
Authors
Showing all 14693 results
Name | H-index | Papers | Citations |
---|---|---|---|
P. Chang | 170 | 2154 | 151783 |
Yang Gao | 168 | 2047 | 146301 |
Bin Liu | 138 | 2181 | 87085 |
P. Sinervo | 138 | 1516 | 99215 |
Filipe Veloso | 128 | 887 | 75496 |
Panagiotis Kokkas | 128 | 1234 | 81051 |
Nuno Filipe Castro | 128 | 960 | 76945 |
Robert Gardner | 128 | 1015 | 77619 |
Francois Corriveau | 128 | 1022 | 75729 |
Peter Krieger | 128 | 1171 | 81368 |
João Carvalho | 126 | 1278 | 77017 |
Helmut Wolters | 126 | 851 | 75721 |
Nicola Venturi | 126 | 796 | 69518 |
Sai-Juan Chen | 121 | 1211 | 73991 |
Harinder Singh Bawa | 120 | 798 | 66120 |