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Institution

University of Coimbra

EducationCoimbra, Portugal
About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Mitochondrion. The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.


Papers
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Journal ArticleDOI
TL;DR: A positive selection of ciprofloxacin-resistant enterococci was indicated by a significant increase in resistance prevalence in treated wastewater compared with the raw wastewater, and no vancomycin resistance was observed among the enteringococci.

244 citations

Journal ArticleDOI
TL;DR: This is the first paper that highlights the novel and future therapeutic perspectives for the treatment of skin malignancies, new therapeutic agents and promising technological approaches, from nanotechnology to immunotherapy.

244 citations

Journal ArticleDOI
12 Aug 2016-Science
TL;DR: The deuteron is too small, too The radius of the proton has remained a point of debate ever since the spectroscopy of muonic hydrogen indicated a large discrepancy from the previously accepted value.
Abstract: The deuteron is the simplest compound nucleus, composed of one proton and one neutron. Deuteron properties such as the root-mean-square charge radius r d and the polarizability serve as important benchmarks for understanding the nuclear forces and structure. Muonic deuterium μd is the exotic atom formed by a deuteron and a negative muon μ – . We measured three 2S-2P transitions in μd and obtain r d = 2.12562 ( 78 ) fm, which is 2.7 times more accurate but 7.5σ smaller than the CODATA-2010 value r d = 2.1424 ( 21 ) fm. The μd value is also 3.5σ smaller than the r d value from electronic deuterium spectroscopy. The smaller r d , when combined with the electronic isotope shift, yields a “small” proton radius r p , similar to the one from muonic hydrogen, amplifying the proton radius puzzle.

244 citations

Journal ArticleDOI
06 Jan 2016-Neuron
TL;DR: In this paper, the authors characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia and found both shared and distinct synaptic and behavioral phenotypes, which may inform exploration of these relationships in human patients.

244 citations

Journal ArticleDOI
05 Jan 2018-Ndt Plus
TL;DR: The epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2016 within 36 countries was described, with the incidence and prevalence higher among men than women, and men had a higher rate of kidney transplantation compared with women.
Abstract: Background This article summarizes the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry's 2015 Annual Report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2015 within 36 countries. Methods In 2016 and 2017, the ERA-EDTA Registry received data on patients who were undergoing RRT for ESRD in 2015, from 52 national or regional renal registries. Thirty-two registries provided individual patient-level data and 20 provided aggregated-level data. The incidence, prevalence and survival probabilities of these patients were determined. Results In 2015, 81 373 individuals commenced RRT for ESRD, equating to an overall unadjusted incidence rate of 119 per million population (pmp). The incidence ranged by 10-fold, from 24 pmp in Ukraine to 232 pmp in the Czech Republic. Of the patients commencing RRT, almost two-thirds were men, over half were aged ≥65 years and a quarter had diabetes mellitus as their primary renal diagnosis. Treatment modality at the start of RRT was haemodialysis for 85% of the patients, peritoneal dialysis for 11% and a kidney transplant for 4%. By Day 91 of commencing RRT, 82% of patients were receiving haemodialysis, 13% peritoneal dialysis and 5% had a kidney transplant. On 31 December 2015, 546 783 individuals were receiving RRT for ESRD, corresponding to an unadjusted prevalence of 801 pmp. This ranged throughout Europe by more than 10-fold, from 178 pmp in Ukraine to 1824 pmp in Portugal. In 2015, 21 056 kidney transplantations were performed, equating to an overall unadjusted transplant rate of 31 pmp. This varied from 2 pmp in Ukraine to 94 pmp in the Spanish region of Cantabria. For patients commencing RRT during 2006-10, the 5-year unadjusted patient survival probabilities on all RRT modalities combined was 50.0% (95% confidence interval 49.9-50.1).

243 citations


Authors

Showing all 14693 results

NameH-indexPapersCitations
P. Chang1702154151783
Yang Gao1682047146301
Bin Liu138218187085
P. Sinervo138151699215
Filipe Veloso12888775496
Panagiotis Kokkas128123481051
Nuno Filipe Castro12896076945
Robert Gardner128101577619
Francois Corriveau128102275729
Peter Krieger128117181368
João Carvalho126127877017
Helmut Wolters12685175721
Nicola Venturi12679669518
Sai-Juan Chen121121173991
Harinder Singh Bawa12079866120
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023112
2022530
20213,237
20203,193
20193,090