University of Cologne

About: University of Cologne is a education organization based out in Cologne, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 32050 authors who have published 66350 publications receiving 2210092 citations. The organization is also known as: Universität zu Köln & Universitatis Coloniensis.

Nonstandard symmetry classes in mesoscopic normal-superconducting hybrid structures

Abstract: Normal-conducting mesoscopic systems in contact with a superconductor are classified by the symmetry operations of time reversal and rotation of the electron's spin. Four symmetry classes are identified, which correspond to Cartan's symmetric spaces of type C, CI, D, and DIII. A detailed study is made of the systems where the phase shift due to Andreev reflection averages to zero along a typical semiclassical single-electron trajectory. Such systems are particularly interesting because they do not have a genuine excitation gap but support quasiparticle states close to the chemical potential. Disorder or dynamically generated chaos mixes the states and produces forms of universal level statistics different from Wigner-Dyson. For two of the four universality classes, the n-level correlation functions are calculated by the mapping on a free one-dimensional Fermi gas with a boundary. The remaining two classes are related to the Laguerre orthogonal and symplectic random-matrix ensembles. For a quantum dot with a normal-metal--superconducting geometry, the weak-localization correction to the conductance is calculated as a function of sticking probability and two perturbations breaking time-reversal symmetry and spin-rotation invariance. The universal conductance fluctuations are computed from a maximum-entropy S-matrix ensemble. They are larger by a factor of 2 than what is naively expected from the analogy with normal-conducting systems. This enhancement is explained by the doubling of the number of slow modes: owing to the coupling of particles and holes by the proximity to the superconductor, every cooperon and diffusion mode in the advanced-retarded channel entails a corresponding mode in the advanced-advanced (or retarded-retarded) channel.

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Abstract: OF the various classes of antibodies that B lymphocytes can produce, class M (IgM) is the first to be expressed on the membrane of the developing cells. Pre-B cells, the precursors of B-lymphocytes, produce the heavy chain of IgM (μ chain), but not light chains1. Recent data suggest that pre-B cells express μ chains on the membrane together with the 'surrogate' light chains λ5 and VpreB (refs 2–7). This complex could control pre-B-cell differentiation, in particular the rearrangement of the light-chain genes8. We have now assessed the importance of the membrane form of the μ chain in B-cell development by generating mice lacking this chain. We disrupted one of the membrane exons of the gene encoding the μ-chain constant region by gene targeting9 in mouse embryonic stem cells10. From these cells we derived mice heterozygous or homozygous for the mutation. B-cell development in the heterozygous mice seemed to be normal, but in homozygous animals B cells were absent, their development already being arrested at the stage of pre-B-cell maturation.