Institution
University of Cologne
Education•Cologne, Germany•
About: University of Cologne is a education organization based out in Cologne, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 32050 authors who have published 66350 publications receiving 2210092 citations. The organization is also known as: Universität zu Köln & Universitatis Coloniensis.
Topics: Population, Transplantation, Gene, Star formation, Cancer
Papers published on a yearly basis
Papers
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TL;DR: Everyday morality science may benefit from a closer look at the antecedents, dynamics, and consequences of everyday moral experience, which revealed that people experience moral events frequently in daily life.
Abstract: The science of morality has drawn heavily on well-controlled but artificial laboratory settings. To study everyday morality, we repeatedly assessed moral or immoral acts and experiences in a large (N = 1252) sample using ecological momentary assessment. Moral experiences were surprisingly frequent and manifold. Liberals and conservatives emphasized somewhat different moral dimensions. Religious and nonreligious participants did not differ in the likelihood or quality of committed moral and immoral acts. Being the target of moral or immoral deeds had the strongest impact on happiness, whereas committing moral or immoral deeds had the strongest impact on sense of purpose. Analyses of daily dynamics revealed evidence for both moral contagion and moral licensing. In sum, morality science may benefit from a closer look at the antecedents, dynamics, and consequences of everyday moral experience.
382 citations
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TL;DR: CSD and PID are described in patients with malignant middle cerebral artery infarction detected by subdural electrocorticography (ECoG) and found to cause secondary neuronal damage and infarct expansion.
Abstract: Summary of Clinical Data Clinical data of the 16 patients (5 male and 11 femalepatients) are summarized in Table 1. Mean age was52.6 years ( 9.7). The left hemisphere was affected in6 and the right in 10 patients. Nine patients had ad-ditional infarction of either the ACA or the posteriorcerebral artery territory. Preoperative Glasgow ComaScale (full range, 3–15) was 10.3 ( 2.9), mean ex-tended Glasgow Outcome Scale (range, 1 [dead] to 8[full recovery to premorbid level]) after 6 months was2.9 ( 1.2). Mean time between stroke onset and op-eration was 34.1 ( 27.5) hours; mean time betweenstroke onset and start of monitoring was 39.8 ( 27.3)hours. Summary of Electrocorticographic Data ECoG data are summarized in Table 2. In the firstpatient, ECoG monitoring yielded continuous techni-cal artifacts; therefore, this patient was excluded fromECoG analysis. Monitoring was initiated soon aftersurgery and return of a patient to the intensive careunit. Aggregate duration of monitoring (all patients)was 1,638.1 hours; mean duration of monitoring perpatient was 109.2 hours ( 37.1). All patients re-mained sedated and ventilated throughout the mea-surement. In three patients, ECoG remained flatthroughout monitoring, and in two of these patients,no SPCs were observed. Seizure activity did not occurin any patient.In total, 127 episodes of CSD were detected in 8patients. In every CSD, a stereotyped SPC spreadingbetween adjacent channels was accompanied by a tran-sient depression of the ECoG activity, which recoveredover time (see Fig 1D). Because each channel displayedthe potential difference between its two active elec-trodes, the spread of the SPC from one electrode to thenext was seen from the phase reversal between twoneighboring channels sharing a common electrode (seeFig 1D, upper traces). In 8 patients, a total of 42 PIDswere observed. All PIDs were characterized by spreadof SPCs between neighboring channels, in the absenceof any pre-event background ECoG activity. Accord-ingly, such SPCs were not accompanied by a depres-sion of ECoG activity. PID therefore represents spread-ing depolarization in otherwise electrically silent tissue.In 4 patients, a total of 65 SPCs did not show clearspread of depolarizations. We kept analysis conservativeand did not include such simultaneous depolarizationsin the further analysis because the criteria for spreadingdepolarizations based on existing experimental andclinical studies specify spread of a depolarization as aprerequisite to score it as CSD or PID.Time delay between onset of monitoring and theDohmen et al: CSD and PID in Human Stroke
382 citations
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TL;DR: This discussion of “designing for comprehension” addresses the second type of task—reading a hyperdocument for learning—that is more adequate for tasks requiring deep understanding and learning.
Abstract: hypermedia, it is necessary to distinguish between two kinds of applications: “One encourages those who wish to wander through large clouds of information, gathering knowledge along the way. The other is more directly tied to specific problem-solving, and is quite structured and perhaps even constrained” [20, p. 119]. Applications of the first type appear as browsable databases—or hyperbases—that can be freely explored by a reader. In contrast, applications of the second type take the shape of electronic documents—or hyperdocuments—that intentionally guide readers through an information space, controlling their exploration along the lines of a predefined structure. Each type has its particular advantages and encourages different reading strategies. While the first one is better suited to support unconstrained search and information retrieval, the second one is more adequate for tasks requiring deep understanding and learning. As Hammond points out, it “may be fun and perhaps instructive, to open every door and peer inside, but there are many situations where learning is most effective when the freedom of the learner is restricted to a relevant and helpful subset of activities.” It is this second type of task—reading a hyperdocument for learning—that we address in our discussion of “designing for comprehension.”
382 citations
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TL;DR: The ring-like assembly of prohibitins and their sequence similarity with lipid raft-associated SPFH-family members suggests a scaffolding function of prohibitin, which may lead to functional compartmentalization in the inner membrane of mitochondria.
382 citations
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TL;DR: The aim of this investigation was to determine whether patients with olfactory loss would benefit from “Training” with odors in terms of an improvement of their general Olfactory function and to produce both an improved sensitivity towards the odors used in the Training process and an overall increase of o aroma function.
Abstract: Objectives:
Olfactory function is known to be modulated by repeated exposure to odors. The aim of this investigation was whether patients with olfactory loss would benefit from “Training” with odors in terms of an improvement of their general olfactory function. It was hypothesized that olfactory Training should produce both an improved sensitivity towards the odors used in the Training process and an overall increase of olfactory function.
Study Design:
The prospective study was performed in patients with olfactory dysfunction.
Methods:
One group of patients performed the Training (n = 40), whereas another part did not (n = 16). Exclusion criteria for patients were sinunasal disease. Olfactory training was performed over a period of 12 weeks. Patients exposed themselves twice daily to four intense odors (phenyl ethyl alcohol: rose, eucalyptol: eucalyptus, citronellal: lemon, and eugenol: cloves). Olfactory testing was performed before and after training using the “Sniffin' Sticks” (thresholds for phenyl ethyl alcohol, tests for odor discrimination and odor identification) in addition to threshold tests for the odors used in the training process.
Results:
Compared to baseline, training patients experienced an increase in their olfactory function, which was observed for the Sniffin' Sticks test score and for thresholds for the odors used in the training process. In contrast, olfactory function was unchanged in patients who did not perform olfactory training. The present results indicate that the structured, short-term exposure to selected odors may increase olfactory sensitivity. Laryngoscope, 119:496–499, 2009
382 citations
Authors
Showing all 32558 results
Name | H-index | Papers | Citations |
---|---|---|---|
Julie E. Buring | 186 | 950 | 132967 |
Stuart H. Orkin | 186 | 715 | 112182 |
Cornelia M. van Duijn | 183 | 1030 | 146009 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Frederick W. Alt | 171 | 577 | 95573 |
Donald E. Ingber | 164 | 610 | 100682 |
Klaus Müllen | 164 | 2125 | 140748 |
Klaus Rajewsky | 154 | 504 | 88793 |
Frederik Barkhof | 154 | 1449 | 104982 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Detlef Weigel | 142 | 516 | 84670 |
Hidde L. Ploegh | 135 | 674 | 67437 |
Luca Valenziano | 130 | 437 | 94728 |
Peter Walter | 126 | 841 | 71580 |
Peter G. Martin | 125 | 553 | 97257 |