University of Cologne

About: University of Cologne is a education organization based out in Cologne, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 32050 authors who have published 66350 publications receiving 2210092 citations. The organization is also known as: Universität zu Köln & Universitatis Coloniensis.

Tissue localization of phenolic compounds in plants by confocal laser scanning microscopy

Abstract: laser scanning microscopy, UV-screening pigments, Picea abies (L.) Karst., Vicia faba L., Secale cereale L., Equisetum Phenolic compounds are involved in many interactions arvense L. of plants with their biotic and abiotic environment. These substances accumulate in different plant tissues and cells during ontogenesis and under the influ- Introduction ence of various environmental stimuli, respectively. Studies on the tissue localization of phenolic com- Phenolic compounds play a major role in the interaction

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11.

Abstract: Rapid intracellular transport and secretion of cytotoxic granules through the immunological synapse requires a balanced interaction of several proteins. Disturbance of this highly regulated process underlies familial hemophagocytic lymphohistiocytosis (FHL), a genetically heterogeneous autosomal-recessive disorder characterized by a severe hyperinflammatory phenotype. Here, we have assigned FHL-5 to a 1 Mb region on chromosome 19p by using high-resolution SNP genotyping in eight unrelated FHL patients from consanguineous families. Subsequently, we found nine different mutations, either truncating or missense, in STXBP2 in twelve patients from Turkey, Saudi Arabia, and Central Europe. STXBP2 encodes syntaxin binding protein 2 (Munc18-2), involved in the regulation of vesicle transport to the plasma membrane. We have identified syntaxin 11, a SNARE protein mutated in FHL-4, as an interaction partner of STXBP2. This interaction is eliminated by the missense mutations found in our FHL-5 patients, which leads to a decreased stability of both proteins, as shown in patient lymphocytes. Activity of natural killer and cytotoxic T cells was markedly reduced or absent, as determined by CD107 degranulation. Our findings thus identify a key role for STXBP2 in lytic granule exocytosis.

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.

Abstract: Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

A photon dominated region code comparison study

Abstract: Aims. We present a comparison between independent computer codes, modeling the physics and chemistry of interstellar photon dominated regions (PDRs). Our goal was to understand the mutual differences in the PDR codes and their effects on the physical and chemical structure of the model clouds, and to converge the output of different codes to a common solution. Methods. A number of benchmark models have been created, covering low and high gas densities n = 10 3 , 10 5.5 cm −3 and far ultraviolet intensities χ = 10, 10 5 in units of the Draine field (FUV: 6 < h ν< 13.6 eV). The benchmark models were computed in two ways: one set assuming constant temperatures, thus testing the consistency of the chemical network and photo-processes, and a second set determining the temperature self consistently by solving the thermal balance, thus testing the modeling of the heating and cooling mechanisms accounting for the detailed energy balance throughout the clouds. Results. We investigated the impact of PDR geometry and agreed on the comparison of results from spherical and plane-parallel PDR models. We identified a number of key processes governing the chemical network which have been treated differently in the various codes such as the effect of PAHs on the electron density or the temperature dependence of the dissociation of CO by cosmic ray induced secondary photons, and defined a proper common treatment. We established a comprehensive set of reference models for ongoing and future PDR model bench-marking and were able to increase the agreement in model predictions for all benchmark models significantly. Nevertheless, the remaining spread in the computed observables such as the atomic fine-structure line intensities serves as a warning that there is still a considerable uncertainty when interpreting astronomical data with our models.

Adaptive urban governance: new challenges for the second generation of urban adaptation strategies to climate change

Abstract: The task of adapting cities to the impacts of climate change is of great importance—urban areas are hotspots of high risk given their concentrations of population and infrastructure; their key roles for larger economic, political and social processes; and their inherent instabilities and vulnerabilities. Yet, the discourse on urban climate change adaptation has only recently gained momentum in the political and scientific arena. This paper reviews the recent climate change adaptation strategies of nine selected cities and analyzes them in terms of overall vision and goals, baseline information used, direct and indirect impacts, proposed structural and non-structural measures, and involvement of formal and informal actors. Against this background, adaptation strategies and challenges in two Vietnamese cities are analyzed in detail, namely Ho Chi Minh City and Can Tho. The paper thereby combines a review of formalized city-scale adaptation strategies with an empirical analysis of actual adaptation measures and constraints at household level. By means of this interlinked and comparative analysis approach, the paper explores the achievements, as well as the shortcomings, in current adaptation approaches, and generates core issues and key questions for future initiatives in the four sub-categories of: (1) knowledge, perspectives, uncertainties and key threats; (2) characteristics of concrete adaptation measures and processes; (3) interactions and conflicts between different strategies and measures; (4) limits of adaptation and tipping points. In conclusion, the paper calls for new forms of adaptive urban governance that go beyond the conventional notions of urban (adaptation) planning. The proposed concept underlines the need for a paradigm shift to move from the dominant focus on the adjustment of physical structures towards the improvement of planning tools and governance processes and structures themselves. It addresses in particular the necessity to link different temporal and spatial scales in adaptation strategies, to acknowledge and to mediate between different types of knowledge (expert and local knowledge), and to achieve improved integration of different types of measures, tools and norm systems (in particular between formal and informal approaches).