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Institution

University of Cologne

EducationCologne, Germany
About: University of Cologne is a education organization based out in Cologne, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 32050 authors who have published 66350 publications receiving 2210092 citations. The organization is also known as: Universität zu Köln & Universitatis Coloniensis.


Papers
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Journal ArticleDOI
14 Jan 1994-Cell
TL;DR: The bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition, allowing development of epidermal progenitor cells.

319 citations

Journal ArticleDOI
TL;DR: In this article, experiments in straight corridors and T-junction are performed to study their effects on the fundamental diagram of pedestrian dynamics, including various self-organization phenomena, and it is shown that they have minor influences for {\rho} < 3.5 m-2.
Abstract: Many observations of pedestrian dynamics, including various self-organization phenomena, have been reproduced successfully by different models. But the empirical databases for quantitative calibration are still insufficient, e.g. the fundamental diagram as one of the most important relationships displays non-negligible differences among various studies. To improve this situation, experiments in straight corridors and T-junction are performed. Four different measurement methods are defined to study their effects on the fundamental diagram. It is shown that they have minor influences for {\rho} <3.5 m-2 but only the Voronoi method is able to resolve the fine-structure of the fundamental diagram. This enhanced measurement method permits to observe the occurrence of boundary-induced phase transition. For corridors of different widths we found that the specific flow concept works well for {\rho} <3.5 m-2. Moreover, we illustrate the discrepancies between the fundamental diagrams of a T-junction and a straight corridor.

318 citations

Journal ArticleDOI
05 Mar 2009-Nature
TL;DR: The trimeric architecture of BetP and the break in three-fold symmetry by the osmosensing C-terminal helices suggest a regulatory mechanism of Na+-coupled osmolyte transport to counteract osmotic stress.
Abstract: Osmoregulated transporters sense intracellular osmotic pressure and respond to hyperosmotic stress by accumulation of osmolytes to restore normal hydration levels. Here we report the determination of the X-ray structure of a member of the family of betaine/choline/carnitine transporters, the Na(+)-coupled symporter BetP from Corynebacterium glutamicum, which is a highly effective osmoregulated uptake system for glycine betaine. Glycine betaine is bound in a tryptophan box occluded from both sides of the membrane with aromatic side chains lining the transport pathway. BetP has the same overall fold as three unrelated Na(+)-coupled symporters. Whereas these are crystallized in either the outward-facing or the inward-facing conformation, the BetP structure reveals a unique intermediate conformation in the Na(+)-coupled transport cycle. The trimeric architecture of BetP and the break in three-fold symmetry by the osmosensing C-terminal helices suggest a regulatory mechanism of Na(+)-coupled osmolyte transport to counteract osmotic stress.

318 citations

Journal ArticleDOI
TL;DR: This review elaborates pedagogically on the fundamental concept, basic theory, expected properties, and materials realizations of topological superconductors.
Abstract: This review elaborates pedagogically on the fundamental concept, basic theory, expected properties, and materials realizations of topological superconductors. The relation between topological superconductivity and Majorana fermions are explained, and the difference between dispersive Majorana fermions and a localized Majorana zero mode is emphasized. A variety of routes to topological superconductivity are explained with an emphasis on the roles of spin-orbit coupling. Present experimental situations and possible signatures of topological superconductivity are summarized with an emphasis on intrinsic topological superconductors.

318 citations

Journal ArticleDOI
TL;DR: In this article, a critical analysis of the classical papers of H. Thirring and J. Lense on rotating masses in the relativistic theory of gravitation is presented.
Abstract: The purpose of this work is to provide a critical analysis of the classical papers of H. Thirring [Phys. Z.,19, 33 (1918);Phys. Z.,22, 29 (1921)] and J. Lense and H. Thirring [Phys. Z.,19, 156 (1918)] on rotating masses in the relativistic theory of gravitation and to render them accessible to a wider circle of scholars. An English translation of these papers is presented which follows the original German text as closely as possible. This is followed by a concise account of the significance of the results of these papers as well as the possibility of measuring the gravitational effects of rotating masses.

318 citations


Authors

Showing all 32558 results

NameH-indexPapersCitations
Julie E. Buring186950132967
Stuart H. Orkin186715112182
Cornelia M. van Duijn1831030146009
Dorret I. Boomsma1761507136353
Frederick W. Alt17157795573
Donald E. Ingber164610100682
Klaus Müllen1642125140748
Klaus Rajewsky15450488793
Frederik Barkhof1541449104982
Stefanie Dimmeler14757481658
Detlef Weigel14251684670
Hidde L. Ploegh13567467437
Luca Valenziano13043794728
Peter Walter12684171580
Peter G. Martin12555397257
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023324
2022634
20214,225
20204,051
20193,526
20183,078