University of Colorado Boulder

About: University of Colorado Boulder is a education organization based out in Boulder, Colorado, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 48794 authors who have published 115151 publications receiving 5387328 citations. The organization is also known as: CU Boulder & UCB.

The SDSS-IV extended baryon oscillation spectroscopic survey: Overview and early data

Abstract: In a six-year program started in 2014 July, the Extended Baryon Oscillation Spectroscopic Survey (eBOSS) will conduct novel cosmological observations using the BOSS spectrograph at Apache Point Observatory. These observations will be conducted simultaneously with the Time Domain Spectroscopic Survey (TDSS) designed for variability studies and the Spectroscopic Identification of eROSITA Sources (SPIDERS) program designed for studies of X-ray sources. In particular, eBOSS will measure with percent-level precision the distance-redshift relation with baryon acoustic oscillations (BAO) in the clustering of matter. eBOSS will use four different tracers of the underlying matter density field to vastly expand the volume covered by BOSS and map the large-scale-structures over the relatively unconstrained redshift range 0.6 0.6 sample of BOSS galaxies. With ~195,000 new emission line galaxy redshifts, we expect BAO measurements of d_A(z) to an accuracy of 3.1% and H(z) to 4.7% at an effective redshift of z = 0.87. A sample of more than 500,000 spectroscopically confirmed quasars will provide the first BAO distance measurements over the redshift range 0.9 2.1; these new data will enhance the precision of dA(z) and H(z) at z > 2.1 by a factor of 1.44 relative to BOSS. Furthermore, eBOSS will provide improved tests of General Relativity on cosmological scales through redshift-space distortion measurements, improved tests for non-Gaussianity in the primordial density field, and new constraints on the summed mass of all neutrino species. Here, we provide an overview of the cosmological goals, spectroscopic target sample, demonstration of spectral quality from early data, and projected cosmological constraints from eBOSS.

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

Abstract: Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes.

Atmospheric GCM Response to Extratropical SST Anomalies: Synthesis and Evaluation*

Abstract: The advances in our understanding of extratropical atmosphere‐ocean interaction over the past decade and a half are examined, focusing on the atmospheric response to sea surface temperature anomalies. The main goal of the paper is to assess what was learned from general circulation model (GCM) experiments over the recent two decades or so. Observational evidence regarding the nature of the interaction and dynamical theory of atmospheric anomalies forced by surface thermal anomalies is reviewed. Three types of GCM experiments used to address this problem are then examined: models with fixed climatological conditions and idealized, stationary SST anomalies; models with seasonally evolving climatology forced with realistic, time-varying SST anomalies; and models coupled to an interactive ocean. From representative recent studies, it is argued that the extratropical atmosphere does respond to changes in underlying SST although the response is small compared to internal (unforced) variability. Two types of interactions govern the response. One is an eddy-mediated process, in which a baroclinic response to thermal forcing induces and combines with changes in the position or strength of the storm tracks. This process can lead to an equivalent barotropic response that feeds back positively on the ocean mixed layer temperature. The other is a linear, thermodynamic interaction in which an equivalent-barotropic low-frequency atmospheric anomaly forces a change in SST and then experiences reduced surface thermal damping due to the SST adjustment. Both processes contribute to an increase in variance and persistence of low-frequency atmospheric anomalies and, in fact, may act together in the natural system.

GLIA: A novel drug discovery target for clinical pain

Abstract: In many clinical pain syndromes, painful sensations are greatly amplified so that normally innocuous sensations, such as light touch or warmth, are perceived as pain. Presently available drugs are ineffective in controlling such pain in most patients and abolish the pain in only few. Why do they fail? These drugs were developed to target neurons that transmit nociceptive ('pain') information. However, glia have recently been recognized as powerful modulators of nociception, and could hold the key to the control of clinical pain and present a new target for drug discovery. This review examines the evidence for glial regulation of nociception and pharmacological approaches that might successfully control glially driven clinical pain syndromes.