Institution
University of Colorado Boulder
Education•Boulder, Colorado, United States•
About: University of Colorado Boulder is a education organization based out in Boulder, Colorado, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 48794 authors who have published 115151 publications receiving 5387328 citations. The organization is also known as: CU Boulder & UCB.
Topics: Population, Galaxy, Context (language use), Poison control, Stars
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors present the complete oxygen isotope record for the Greenland Ice Sheet Project 2 (GISP2) core, drilled 28 km west of the GRIP core, and observe large, rapid climate fluctuations throughout the last glacial period.
Abstract: RECENT results1,2 from the Greenland Ice-core Project (GRIP) Summit ice core suggest that the climate in Greenland has been remarkably stable during the Holocene, but was extremely unstable for the time period represented by the rest of the core, spanning the last two glaciations and the intervening Eemian inter-glacial. Here we present the complete oxygen isotope record for the Greenland Ice Sheet Project 2 (GISP2) core, drilled 28 km west of the GRIP core. We observe large, rapid climate fluctuations throughout the last glacial period, which closely match those reported for the GRIP core. However, in the bottom 10% of the cores, spanning the Eemian interglacial and the previous glacia-tion, there are significant differences between the two records. It is possible that ice flow may have altered the chronological sequences of the stratigraphy for the bottom part of one or both of the cores. Considerable further work will be necessary to evaluate the likelihood of this, and the extent to which it will still be possible to extract meaningful climate information from the lowest sections of the cores.
1,885 citations
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TL;DR: It is shown, using two cognitive procedural learning tasks, that Parkinson's patients off medication are better at learning to avoid choices that lead to negative outcomes than they are at learning from positive outcomes.
Abstract: To what extent do we learn from the positive versus negative outcomes of our decisions? The neuromodulator dopamine plays a key role in these reinforcement learning processes. Patients with Parkinson's disease, who have depleted dopamine in the basal ganglia, are impaired in tasks that require learning from trial and error. Here, we show, using two cognitive procedural learning tasks, that Parkinson's patients off medication are better at learning to avoid choices that lead to negative outcomes than they are at learning from positive outcomes. Dopamine medication reverses this bias, making patients more sensitive to positive than negative outcomes. This pattern was predicted by our biologically based computational model of basal ganglia-dopamine interactions in cognition, which has separate pathways for "Go" and "NoGo" responses that are differentially modulated by positive and negative reinforcement.
1,877 citations
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TL;DR: The pathway of ncRNA research is described, where every established "rule" seems destined to be overturned.
1,875 citations
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TL;DR: The Community Earth System Model (CESM) community designed the CESM Large Ensemble with the explicit goal of enabling assessment of climate change in the presence of internal climate variability as discussed by the authors.
Abstract: While internal climate variability is known to affect climate projections, its influence is often underappreciated and confused with model error. Why? In general, modeling centers contribute a small number of realizations to international climate model assessments [e.g., phase 5 of the Coupled Model Intercomparison Project (CMIP5)]. As a result, model error and internal climate variability are difficult, and at times impossible, to disentangle. In response, the Community Earth System Model (CESM) community designed the CESM Large Ensemble (CESM-LE) with the explicit goal of enabling assessment of climate change in the presence of internal climate variability. All CESM-LE simulations use a single CMIP5 model (CESM with the Community Atmosphere Model, version 5). The core simulations replay the twenty to twenty-first century (1920–2100) 30 times under historical and representative concentration pathway 8.5 external forcing with small initial condition differences. Two companion 1000+-yr-long preindu...
1,869 citations
Authors
Showing all 49233 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
Rob Knight | 201 | 1061 | 253207 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Jie Zhang | 178 | 4857 | 221720 |
David Haussler | 172 | 488 | 224960 |
Bradley Cox | 169 | 2150 | 156200 |
Gang Chen | 167 | 3372 | 149819 |
Rodney S. Ruoff | 164 | 666 | 194902 |
Menachem Elimelech | 157 | 547 | 95285 |
Jay Hauser | 155 | 2145 | 132683 |
Robert E. W. Hancock | 152 | 775 | 88481 |
Robert Plomin | 151 | 1104 | 88588 |
Thomas E. Starzl | 150 | 1625 | 91704 |
Rajesh Kumar | 149 | 4439 | 140830 |