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Showing papers by "University of Colorado Colorado Springs published in 2000"


Journal ArticleDOI
TL;DR: In this article, a comparison of the strategies employed in management research in two periods, 1995-97 and 1985-87, was conducted through a content analysis of articles from the Academy of Management Journal.
Abstract: This study is a comparison of the strategies employed in management research in two periods, 1995–97 and 1985–87. Through a content analysis of articles from the Academy of Management Journal, Admi...

1,162 citations


Journal ArticleDOI
TL;DR: A configurational model for classifying mass customizer based on customer involvement in design and product modularity is developed and validated through an empirical analysis and classification of 126 mass customizers.

749 citations


Journal ArticleDOI
TL;DR: In this article, the authors developed a conceptual model of manufacturing strategy from the literature and tested the model using data from a sample of manufacturers in three industries in the United States and found that competitive strategy acts as a mediator between an organization's environment and its manufacturing strategy.

675 citations


Journal ArticleDOI
TL;DR: The Self-Determined Learning Model of Instruction as discussed by the authors ) is a model of teaching that incorporates principles of self-determination, which enables teachers to teach students to become causal agents in their own lives.
Abstract: Teachers seeking to promote the self-determination of their students must enable them to become self-regulated problem-solvers. This article introduces a model of teaching, The Self-Determined Learning Model of Instruction, incorporating principles of self-determination, which enables teachers to teach students to become causal agents in their own lives. This model was field-tested with students with disabilities. Students receiving instruction from teachers using the model attained educationally relevant goals, showed enhanced self-determination, and communicated their satisfaction with the process. Teachers implementing the model likewise indicated their satisfaction with the process and suggested that they would continue to use the model after the completion of the field test.

421 citations



Journal ArticleDOI
TL;DR: In this article, the authors examined the relationship between multiple sales force management practices and performance within each of Miles and Snow's (1978) strategy types and found substantial support for the general proposition that the different strategy types require individualized profiles of management practices for optimal effectiveness.
Abstract: The basic premise of the strategy implementation literature is that different business strategies require different configurations of organizational practices to achieve optimal performance. Sales force management is a key functional activity and should contribute to the successful implementation of business strategy. In this study, we examine the relationship between multiple sales force management practices and performance within each of Miles and Snow's (1978) strategy types. The explanatory power of the eight models tested is quite high (incremental adjusted R2 ≥ 0.25 for six of the eight models). Thus, we find substantial support for the general proposition that the different strategy types require individualized profiles of sales force management practices for optimal effectiveness and that sales force management is important to the successful implementation of business strategy. Copyright © 2000 John Wiley & Sons, Ltd.

388 citations


Journal ArticleDOI
TL;DR: The results of a study investigating the link between resistance reasons and system types and assessing managerial perceptions of the relative importance of various strategies for promoting acceptance in the context of those types suggest that decision support systems and transaction processing systems are resisted for different reasons.

300 citations


Journal ArticleDOI
TL;DR: The growth-suppressive effect of BDP remained consistent across all age and gender subgroups, and among subjects with and without a previous history of corticosteroid use, and in both analyses, overall growth rate was significantly slower in BDP- treated subjects than placebo-treated subjects.
Abstract: Objective. Intranasal beclomethasone dipropionate (BDP) has generally been considered to have no systemic activity at recommended doses, but the potential for long-term effects on growth has not previously been evaluated. This study was undertaken to assess the effects of 1 year of treatment with intranasal BDP on growth in children. Study Design. In this double-blind, randomized, parallel-group study, 100 prepubertal children 6 to 9 years old with perennial allergic rhinitis were treated with aqueous BDP 168 μg twice daily ( n = 51) or placebo ( n = 49) for 1 year. Subjects9 baseline heights were required to be between the 5th and 95th percentile, and skeletal age as determined by left wrist radiograph was required to be within 2 years of chronological age. Washout periods for medications known to affect growth, including other forms of corticosteroids, were established, and these medications were prohibited during the study. However, short courses of oral prednisolone lasting no more than 7 days, and short courses of dermatologic corticosteroids lasting no more than 10 days, were allowed. Height was measured with a stadiometer after 1, 2, 4, 6, 8, 10, and 12 months of treatment. The hypothalamic-pituitary-adrenocortical axis was assessed by measurements of 8 am basal cortisol concentrations and response to .25 mg cosyntropin stimulation. The primary safety parameter was the rate of change in standing height. Statistical analyses were based on all randomized subjects who received at least 1 dose of medication (intent-to-treat principle). The rate of change in standing height was analyzed for all subjects who entered the study and for those completing the full 12 months of treatment ( n = 80). The rate of change in standing height over the 1-year study was calculated as the slope of a linear regression line fitted to each subject9s height measurements over time. Because there was a statistically significant between-group difference in standing height at baseline, an analysis of covariance was performed for all analyses of standing height data. Results. Of the 100 subjects enrolled, 90 completed the study. The 2 treatment groups were generally comparable at baseline; however, at baseline, mean age and mean height were significantly greater in the BDP treatment group that the in placebo treatment group. In both analyses, overall growth rate was significantly slower in BDP-treated subjects than placebo-treated subjects. The mean change in standing height after 1 year was 5.0 cm in the BDP-treated subjects compared with 5.9 cm in the placebo-treated subjects. The difference in growth rates was evident as early as the 1-month treatment visit, suggesting that the effect on growth occurred initially. The growth-suppressive effect of BDP remained consistent across all age and gender subgroups, and among subjects with and without a previous history of corticosteroid use. Use of additional exogenous corticosteroids during the study was similar in both groups and did not affect the results. Because there was a baseline imbalance in height, a supplemental analysis of the differences in prestudy growth rates was performed. This analysis found no baseline imbalance in prestudy growth rates. To determine whether the difference in growth rates during the study could be attributed to preexisting growth rates, a z score analysis was performed. The heights of both groups were normalized at baseline and at the end of the study using the US National Center for Health Statistics data for mean and standard deviations of height. This analysis confirmed that the difference in growth rates between the 2 groups was primarily attributable to the treatment rather than to any preexisting difference in growth. Additional analyses confirmed that the results were not influenced by outlier values. No significant between-group difference were found in the hypothalamic-pituitary-adrenocortical axis assessments. No unusual adverse events were observed. No evidence of other systemic effects of BDP was found, including analysis for fluid and electrolyte imbalances; alterations in protein, lipid, or carbohydrate metabolism; alterations in formed elements in blood; and alterations in differential white blood cell counts, including eosinophils. Conclusions. Additional study is warranted to define the clinical relevance of these findings. This study suggests, however, that intranasal BDP may slow growth rate in children without suppressing basal 6 am cortisol concentrations or the response to cosyntropin stimulation, which are commonly used clinically to test for adrenal suppression. The effect on final height is unknown. Alterative explantations for the finding of drug-induced growth suppression, including the possibility that the results were affected by either differences in height and age at baseline between the 2 groups or by outlier values, were discounted upon additional analysis. The results of this study were considered by the Food and Drug Administration in the development of recently proposed new class labeling for all inhaled and intranasal corticosteroids, which states that these agents may cause a reduction in growth velocity in pediatric patients (see reference 21). However, both the Food and Drug Administration and several professional bodies in the United States concur that, depending on disease severity, the benefits of intranasal corticosteroid therapy may outweigh the risks (see reference 22). Because the effect, if any, on final height in not known, the height of children receiving long-term therapy should be monitored periodically during treatment, and should be plotted on a growth or growth-velocity chart to monitor for growth suppression. To minimize the risks of systemic corticosteroid exposure, including growth suppresson, dose-reduction strategies should be considered. For patients who concomitantly receive exogenous corticosteroids via other routes for other conditions, such as inhaled corticosteroids for asthma, clinicians should consider the total corticosteroid exposure and titrate each patient to the lowest effective dose. Clinicians should also consider each medication9s potential for systemic effects when selecting among the various available corticosteroids. beclomethasone dipropionate, intranasal corticosteroids, growth, allergic rhinitis, pediatric.

294 citations


Journal ArticleDOI
TL;DR: EIB is prevalent in several Olympic winter sports and affects nearly one of every four elite winter sport athletes; the winter sport with the highest incidence of EIB is cross-country skiing; in general, E IB is more prevalent in female versus male elite winterSport athletes; and athletes may compete successfully at the international level despite having EIB.
Abstract: WILBER, R. L., K. W. RUNDELL, L. SZMEDRA, D. M. JENKINSON, J. IM, and S. D. DRAKE. Incidence of exercise-induced bronchospasm in Olympic winter sport athletes. Med. Sci. Sports Exerc., Vol. 32, No. 4, pp. 732‐737, 2000. Purpose: The purpose of this project was to determine the incidence of exercise-induced bronchospasm (EIB) among U.S. Olympic winter sport athletes. Methods: Subjects included female and male members of the 1998 U.S. Winter Olympic Team from the following sports: biathlon, cross-country ski, figure skating, ice hockey, Nordic combined, long-track speedskating, and short-track speedskating. Assessment of EIB was conducted in conjunction with an “actual competition” (Olympic Trials, World Team Trials, World Cup Event, U.S. National Championships) or a “simulated competition” (time trial, game), which served as the exercise challenge. Standard spirometry tests were performed preexercise and at 5, 10, and 15 min postexercise. An athlete was considered EIB-positive based on a postexercise decrement in FEV1 $ 10%. Results: For the seven sports evaluated on the 1998 U.S. Winter Olympic Team, the overall incidence of EIB across all sports and genders was 23%. The highest incidence of EIB was found in cross-country skiers, where 50% of the athletes (female 5 57%; male 5 43%) were diagnosed with EIB. Across the seven sports evaluated, the prevalence of EIB among the female and male athletes was 26% and 18%, respectively. Among those individuals found to be EIB-positive were athletes who won a team gold medal, one individual silver medal, and one individual bronze medal at the Nagano Winter Olympics. Conclusions: These data suggest that: 1) EIB is prevalent in several Olympic winter sports and affects nearly one of every four elite winter sport athletes; 2) the winter sport with the highest incidence of EIB is cross-country skiing; 3) in general, EIB is more prevalent in female versus male elite winter sport

264 citations


Journal ArticleDOI
TL;DR: In this article, the authors tested the hypothesis that death-related thought first activates direct defenses to minimize the threat (proximal defense) and then later triggers symbolic cultural worldview defense (distal defense).
Abstract: The present study was designed to build on prior terror management research by testing the hypothesis that death-related thought first activates direct defenses to minimize the threat (proximal defense) and then later triggers symbolic cultural worldview defense (distal defense). After mortality salience, participants were either distracted from death-related thought or not and then completed either a measure of distal defense and then a measure of proximal defense or a proximal defense measure and then a distal defense measure. Results supported the authors’ predictions. Proximal defense in the form of vulnerability denial emerged only when participants had immediately before been thinking about death. In contrast, distal defense only emerged when participants were previously distracted from death-related thought. Discussion focuses on implications of these results for understanding the sequence of defenses initiated by mortality salience.

260 citations


Journal ArticleDOI
TL;DR: In this paper, the authors evaluated the life cycle energy, greenhouse gas emissions, and costs of a contemporary 2,450 sq ft (228 m3) U.S. residential home (the standard home, or SH) and found that the use phase accounted for 91% of the total life-cycle energy consumption over a 50-year home life.
Abstract: Summary The life-cycle energy, greenhouse gas emissions, and costs of a contemporary 2,450 sq ft (228 m3) U.S. residential home (the standard home, or SH) were evaluated to study opportunities for conserving energy throughout pre-use (materials production and construction), use (including maintenance and improvement), and demolition phases. Home construction and maintenance materials and appliances were inventoried totaling 306 metric tons. The use phase accounted for 91% of the total life-cycle energy consumption over a 50-year home life. A functionally equivalent energy-efficient house (EEH) was modeled that incorporated 11 energy efficiency strategies. These strategies led to a dramatic reduction in the EEH total life-cycle energy; 6,400 GJ for the EEH compared to 16,000 GJ for the SH. For energy-efficient homes, embodied energy of materials is important; pre-use energy accounted for 26% of life-cycle energy. The discounted (4%) life-cycle cost, consisting of mortgage, energy, maintenance, and improvement payments varied between 426,700 and 454,300 for a SH using four energy price forecast scenarios. In the case of the EEH, energy cost savings were offset by higher mortgage costs, resulting in total life-cycle cost between 434,100 and 443,200. Life-cycle greenhouse gas emissions were 1,010 metric tons CO2 equivalent for an SH and 370 metric tons for an EEH.

Journal ArticleDOI
TL;DR: It is shown that partial hepatectomy, which triggers the immediate onset of liver regeneration, protected mice against the lethal effects of Fas-specific antibodies and prevented hepatocyte apoptosis in response to Fas engagement in vivo.
Abstract: Fas (CD95) is a receptor involved in induction of apoptotic cell death of Fas-bearing cells, including hepatocytes and T cells. Injection of Fas-specific antibodies into mice leads to fulminant hepatic failure and death. Fas also transduces growth-promoting signals in proliferating T cells, fibroblasts and some tumor cells. Here we show that partial hepatectomy, which triggers the immediate onset of liver regeneration, protected mice against the lethal effects of Fas-specific antibodies and prevented hepatocyte apoptosis in response to Fas engagement in vivo. Furthermore, Fas engagement accelerated liver regeneration after partial hepatectomy. Liver regeneration kinetics were delayed in mutant mice with decreased cell surface Fas expression (lpr mice). In contrast, regeneration was not delayed in lpr-cg mutant mice, which have a Fas mutation that prevents Fas-induced death but not Fas-dependent proliferative stimulation. Our results indicate that Fas engagement on cells in regenerating or healing tissues may promote cell growth.

Journal ArticleDOI
TL;DR: The results of a survey of 86 project managers indicate common aspects of project effectiveness are generally under control, but are most effected by lack of expertise on the project team, and lack of clear role definition and conflicts on the team are also elevated risks.

Journal ArticleDOI
TL;DR: The human body is problematic because it serves as a perpetual reminder of the inevitability of death as discussed by the authors, and the psychological impetus for distancing from other animals and the need to regulate behaviors that remind us of our physical nature.
Abstract: From the perspective of terror management theory, the human body is problematic because it serves as a perpetual reminder of the inevitability of death. Human beings confront this problem through the development of cultural worldviews that imbue reality-and the body as part of that reality-with abstract symbolic meaning. This fanciful flight from death is in turn the psychological impetus for distancing from other animals and the need to regulate behaviors that remind us of our physical nature. This analysis is applied to questions concerning why people are embarrassed and disgusted by their bodies' functions; why sex is such a common source of problems, difficulties, regulations, and ritualizations; why sex tends to be associated with romantic love; and why cultures value physical attractiveness and objectify women. This article then briefly considers implications of this analysis for understanding psychological problems related to the physical body and cultural variations in the need to separate oneself...

Journal ArticleDOI
TL;DR: The hypothesis derived from terror management theory that reminding people of their mortality increases self-esteem striving in the form of identification with one's body, interest in sex, and appearance monitoring is tested.
Abstract: The present research investigated the role of the physical body as a source of self-esteem and tested the hypothesis derived from terror management theory that reminding people of their mortality increases self-esteem striving in the form of identification with one's body, interest in sex, and appearance monitoring. The results revealed that individuals high in body esteem responded to mortality salience manipulations with increased identification with their physical bodies in Study 1 and with increased interest in sex in Study 2. Study 3 showed that reminders of death led to decreased appearance monitoring among appearance-oriented participants who were low in body esteem. These findings provide insight into why people often go to extreme lengths to meet cultural standards for the body and its appearance.

Journal ArticleDOI
TL;DR: Today's information system function includes a large service component and the SERVQUAL instrument can serve as a useful indicator for information system managers attempting to identify areas of needed service improvement and to researchers seeking a success measure of information system services.
Abstract: Today's information system function includes a large service component. Recent research has examined the SERVQUAL instrument as a possible measure to assist managers and researchers in evaluating service quality. To further examine the appropriateness of the SERVQUAL measure, a large industry sample serves to verify the anticipated structure of the instrument. In addition, a high correlation with a common measure of user satisfaction indicates that the SERVQUAL metric may indeed represent accurate views of user perception. As such, the SERVQUAL instrument can serve as a useful indicator for information system managers attempting to identify areas of needed service improvement and to researchers seeking a success measure of information system services.

Journal ArticleDOI
TL;DR: It is concluded that asthma appeared to have been more common in athletes who participated in the 1998 Winter Games than in athleteswho participated in either the 1996 or 1984 Summer Games, and the environment in which exercise is performed is important in leading to a decrease in the amount of exercise required to trigger asthma.
Abstract: Background: About one of every 5 athletes who participated in the 1996 Summer Olympic Games in Atlanta had a past history of asthma, had symptoms that suggested asthma, or took asthma medications. No previous study has determined the prevalence of asthma in all US athletes who participated in an Olympic Winter Games. Objectives: We sought to determine how many US athletes who participated in the 1998 Olympic Winter Games had a past history of asthma, had symptoms that suggested asthma, or indicated taking a medication used to treat asthma. Methods: We evaluated responses to questions that asked about allergic and respiratory diseases in the United States Olympic Committee Medical History Questionnaire that was completed by all 196 athletes who represented the United States at the 1998 Olympic Winter Games in Nagano, Japan. Results: Forty-three (21.9%) of the 196 athletes had a previous diagnosis of asthma, and 36 (18.4%) recorded use of an asthma medication at some time in the past. Forty-four (22.4%) reported use of an asthma medication, a diagnosis of asthma, or both (our basis for the diagnosis of asthma). Thirty-four (17.4%) of the athletes were currently taking an asthma medication at the time that they completed the questionnaire or indicated that they took these medications on a permanent or semipermanent basis and were considered to have active asthma. Athletes who participated in Nordic combined, cross-country, and short track events had the highest prevalence of having been told that they had asthma or had taken an asthma medication in the past (60.7%) in contrast with only one (2.8%) of the 36 athletes who participated in bobsled, biathlon, luge, and ski jumping. Eighteen (24%) of 75 athletes who participated in alpine, long track, figure skating, snow boarding, and curling had a previous diagnosis of asthma or recorded use of an asthma medication. Conclusions: We conclude that asthma appeared to have been more common in athletes who participated in the 1998 Winter Games than in athletes who participated in either the 1996 or 1984 Summer Games. Clearly, asthma rates vary widely among sports. This suggests that the environment in which exercise is performed is important in leading to a decrease in the amount of exercise required to trigger asthma and perhaps in causing injury to the airways. (J Allergy Clin Immunol 2000;106:267-71.)

Journal ArticleDOI
TL;DR: Arthroscopic debridement is a reasonable approach for treating early glenohumeral osteoarthritis that has failed to respond to nonoperative treatment, in which the humeral head and glenoid remain concentric, and where there is still a visible joint space on an axillary radiograph.
Abstract: Twenty-five patients underwent arthroscopic debridement to treat early glenohumeral osteoarthritis. The group consisted of 19 men and 6 women with an average age of 46 years (range, 27 to 72 years.) The operative procedure consisted of lavage of the glenohumeral joint, debridement of labral tears and chondral lesions, loose body removal, and partial synovectomy and subacromial bursectomy. Follow-up averaged 34 months, with a range of 12 to 63 months. Overall, results were rated as excellent in 2 patients (8%), good in 19 patients (72%), and unsatisfactory in 5 (20%). Two patients had complete relief of pain, 18 patients had only occasional mild pain, and 5 had moderate to severe pain postoperatively. Of the 12 patients with marked preoperative stiffness, 10 (83%) had improvement in range of motion postoperatively. Arthroscopic debridement is a reasonable approach for treating early glenohumeral osteoarthritis that has failed to respond to nonoperative treatment, in which the humeral head and glenoid remain concentric, and where there is still a visible joint space on an axillary radiograph. The procedure is not recommended when there is severe joint incongruity or large osteophytes.

Journal ArticleDOI
TL;DR: In this paper, the authors report an initial attempt to operationalize perceived teacher confirmation in behavioral terms and explore relationships among perceived teacher confirmations, cognitive learning, and affective learning.
Abstract: This article reports an initial attempt to operationalize perceived teacher confirmation in behavioral terms and to explore relationships among perceived teacher confirmation, cognitive learning, and affective learning. Results for 2 samples (N = 446; N = 303) indicate that the final 16-item version of the Teacher Confirmation scale (TCS) is valid and reliable. Confirmatory factor analysis revealed that teacher confirmation is best represented by a 3-factor solution: (a) teachers’ response to students’ questions-comments, (b) demonstrated interest in students and in their learning, and (c) teaching style. Results also indicate that teacher confirmation plays a significant role in college students’ cognitive and affective learning. For Sample 1, confirmation uniquely explained 18% of the variance in cognitive learning and 30% of the variance in affective learning, after controlling for demographic variables and relevance of assignments. For Sample 2, confirmation uniquely explained 17.6% of the variance in cognitive learning and 31% of the variance in affective learning, after controlling for the same variables. Structural equation modeling revealed strong, significant paths between confirmation and affective learning and between affective and cognitive learning. The study revealed a large, significant, indirect effect of teacher confirmation on cognitive learning, suggesting that affective learning serves as a mediating variable between teacher confirmation and cognitive learning. A multiple groups comparison demonstrated that the structural model was invariant for the 2 samples.

Journal ArticleDOI
TL;DR: Standardized use of sanctions and privileges for deceptive and nondeceptive polygraph results, respectively, are proposed as a way of eliciting full disclosure of offending histories for these offenders.
Abstract: Sexual offenders are extremely reluctant to disclose their offending histories for a variety of psychosocial and legal reasons. The polygraph has shown promise as a intervention for eliciting admissions of past sexual offending behaviors. For 60 adult male sexual offender (35 inmates and 25 parolees), the number of victims and offenses were recorded from the Presentence Investigative Report, Sexual History Disclosure form, and 2 consecutive polygraph examination reports. Dramatic increases in the number of admitted victims and offenses were found for inmates, but not for parolees, across each source. However, there was a substantial decline in the number of victim and offense admissions by the second polygraph examination for both groups, even though 80% of the examination results reveled deception about sexual offending behaviors. Standardized use of sanctions and privileges for deceptive and nondeceptive polygraph results, respectively, are proposed as a way of eliciting full disclosure of offending histories for these offenders.


Journal ArticleDOI
TL;DR: In this paper, the authors argue that the mere existence of people with different beliefs threatens our primary basis of psychological security; we therefore respond by derogation, assimilation efforts, or annihilation.
Abstract: Terror management theory posits that awareness of mortality engenders a potential for paralyzing terror, which is assuaged by cultural worldviews: humanly created, shared beliefs that provide individuals with the sense they are valuable members of an enduring, meaningful universe (self-esteem), and hence are qualified for safety and continuance beyond death. Thus, self-esteem serves the fundamental psychological function of buffering anxiety. In support of this view, studies have shown that bolstering selfesteem reduces anxiety and that reminders of mortality intensify striving for self-esteem; this research suggests that self-esteem is critical for psychological equanimity. Cultural worldviews serve the fundamental psychological function of providing the basis for death transcendence. To the extent this is true, reminders of mortality should stimulate bolstering of one’s worldview. More than 80 studies have supported this idea, most commonly by demonstrating that making death momentarily salient increases liking for people who support one’s worldview and hostility toward those with alternative worldviews. This work helps explain human beings’ dreadful history of intergroup prejudice and violence: The mere existence of people with different beliefs threatens our primary basis of psychological security; we therefore respond by derogation, assimilation efforts, or annihilation.

Journal ArticleDOI
TL;DR: The results of the multivariate twin analyses suggest that ADHD shares most of its genetic liability with CD, ODD, and EF deficits, and argue for a common biological risk underlying these commonly comorbid externalizing behavior problems and cognitive deficits.
Abstract: The heritability and comorbidity of attention deficit hyperactivity disorder (ADHD) with conduct disorder (CD), oppositional defiant disorder (ODD), and executive function (EF) deficits were examined in 224 child twins (140 monozygotic and 84 dizygotic). The Coolidge Personality and Neuropsychological Inventory for Children (Coolidge, 1998), a standardized, 200-item, Diagnostic and Statistical Manual of Mental Disorders (4th ed.; American Psychiatric Association, 1994) aligned, parent-as-respondent inventory, assessed psychopathology. Structural equation model fitting revealed that the individual scale heritabilities were substantial: .82 for ADHD, .74 for CD, .61 for ODD, and .77 for EF deficits. The results of the multivariate twin analyses suggest that ADHD shares most of its genetic liability with CD, ODD, and EF deficits. Thus, the findings argue for a common biological risk underlying these commonly comorbid externalizing behavior problems and cognitive deficits. The residual genetic variance provides preliminary support for additional genetic influences underlying CD, ODD, and EF that are independent of ADHD.

Journal ArticleDOI
TL;DR: Flow cytometry revealed a difference in the γδ cell subsets in the two strains, with Vγ1 dominating in C57BL/6 mice, and Vγ4 predominating Bl.Tg.Eα mice, suggesting that these two Vγ-defined subsets might have different functions.
Abstract: Coxsackievirus B3 infections of C57BL/6 mice, which express the MHC class II IA but not IE Ag, results in virus replication in the heart but minimal myocarditis. In contrast, Bl.Tg.Ealpha mice, which are C57BL/6 mice transgenically induced to express IE Ag, develop significant myocarditis upon Coxsackievirus B3 infection. Despite this difference in inflammatory damage, cardiac virus titers are similar between C57BL/6 and Bl.Tg.Ealpha mice. Removing gammadelta T cells from either strain by genetic manipulation (gammadelta knockout(ko)) changes the disease phenotype. C57BL/6 gammadelta ko mice show increased myocarditis. In contrast, Bl.Tg.Ealpha gammadelta ko mice show decreased cardiac inflammation. Flow cytometry revealed a difference in the gammadelta cell subsets in the two strains, with Vgamma1 dominating in C57BL/6 mice, and Vgamma4 predominating Bl.Tg.Ealpha mice. This suggests that these two Vgamma-defined subsets might have different functions. To test this possibility, we used mAb injection to deplete each subset. Mice depleted of Vgamma1 cells showed enhanced myocarditis, whereas those depleted of Vgamma4 cells suppressed myocarditis. Adoptively transfusing enriched Vgamma4(+) cells to the C57BL/6 and Bl.Tg. Ealpha gammadelta ko strains confirmed that the Vgamma4 subset promoted myocarditis. Th subset analysis suggests that Vgamma1(+) cells biased the CD4(+) T cells to a dominant Th2 cell response, whereas Vgamma4(+) cells biased CD4(+) T cells toward a dominant Th1 cell response.

Journal ArticleDOI
TL;DR: Examination of the interrelationships among anxiety, personality disorders, and coping strategies in anxious older adults indicated that the prevalence of generalized anxiety states was relatively low and similar in both older and younger groups and dependent on measurement scale and criterion.

Journal ArticleDOI
TL;DR: This paper explored the rural origins of the militia movement, its social composition, ideology, and organization, and its articulation with other white supremacist groups, arguing that their vision of masculinity, particularly a self-reliant, self-made masculinity endemic to American history, is the theme unifying both the ideology and the organization of rural militias with the militant right-wing continuum of which they are only a part.
Abstract: The appearance of right-wing militias was a much-discussed phenomenon during the past decade. Commentators rightly pointed out their rural origins, their lower-middle-class and middle-class composition, and their ideology rooted in racism, sexism, anti-Semitism, and homophobia, but few, if any, have commented on the most salient aspect of all: that these are movements of men, who use narratives about masculinity as an analytic prism through which to understand their own situation and to problematize the identities of "others," and as a rhetorical strategy to recruit and sustain their own membership. In this paper we undertake this analysis, exploring the rural origins of the militia movement, its social composition, ideology, and organization, and its articulation with other white supremacist groups. We argue that their vision of masculinity, particularly a self-reliant, self-made masculinity endemic to American history, is the theme unifying both the ideology and the organization of rural militias with the militant right-wing continuum of which they are only a part. Language: en

Journal ArticleDOI
TL;DR: This paper found that judgments of coping self-efficacy taken 2 months after the bombing added significantly to the explanation of general and trauma-related distress after controlling for income, social support, threat of death, and loss of resources.
Abstract: Findings from a study of 27 victims of the Oklahoma City bombing are reported. This research focused on the importance of subjective appraisals of coping self-efficacy in predicting psychological distress following this tragedy. Results supported the hypothesis that judgments of coping self-eficacy taken 2 months after the bombing added significantly to the explanation of general and trauma-related distress after controlling for income, social support, threat of death, and loss of resources. Coping self-eficacy judgments taken I year later were also important in explaining psychological distress after controlling for loss of resources and social-support perceptions. Although coping self-efficacy perceptions taken at 2 months were related to distress levels 1 year later, they did not remain significant in a regression analysis controlling for loss of resources and income. Implications of these findings for post-terrorist bombing interventions are discussed.

Journal ArticleDOI
TL;DR: The problem of word spotting in handwritten archives is approached by matching global shape features by using a set of visual templates to define the keyword class of interest, and initiate a search for words exhibiting high shape similarity to the model set.
Abstract: The problem of word spotting in handwritten archives is approached by matching global shape features. A set of visual templates is used to define the keyword class of interest, and initiate a search for words exhibiting high shape similarity to the model set. Major problems of segmenting cursive script into individual words are avoided by applying line-oriented processing to the document pages. The use of profile-oriented features facilitates the application of dynamic programming techniques to pattern matching, and allows us to achieve high levels of recognition performance. Results of experiments with old Spanish manuscripts show a high recognition rate of the proposed approach.

Journal ArticleDOI
TL;DR: Differences in soft tissue injury frequency among athletes of differing DSOs suggest that the competitive use of adaptive or assistive devices, in combination with sport-specific stressors and the athletes' disabilities, is related to the development of predictablesoft tissue injury patterns.

Proceedings ArticleDOI
10 Dec 2000
TL;DR: This paper presents an overview of the concept and features of the CORSim traffic simulation program and the TSIS package that provides an integrated, user-friendly interface and environment for executing CORSIM.
Abstract: This paper presents an overview of the concept and features of the CORSIM traffic simulation program and the TSIS package that provides an integrated, user-friendly interface and environment for executing CORSIM. The new functions and feature of CORSIM and TSIS in the most recent release are highlighted. Several successful TSIS/CORSIM applications are used to demonstrate that CORSIM is a very effective tool for performing traffic operations analysis and to evaluate new ITS technologies.