University of Colorado Colorado Springs

About: University of Colorado Colorado Springs is a education organization based out in Colorado Springs, Colorado, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 6664 authors who have published 10872 publications receiving 323416 citations. The organization is also known as: UCCS & University of Colorado at Colorado Springs.

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Abstract: People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication fatigue that might lead to suboptimal treatment adherence and the emergence of drug-resistant viral variants, thereby limiting future treatment options1–3. As such, there is strong interest in long-acting antiretroviral (ARV) agents that can be administered less frequently4. Herein, we report GS-CA1, a new archetypal small-molecule HIV capsid inhibitor with exceptional potency against HIV-2 and all major HIV-1 types, including viral variants resistant to the ARVs currently in clinical use. Mechanism-of-action studies indicate that GS-CA1 binds directly to the HIV-1 capsid and interferes with capsid-mediated nuclear import of viral DNA, HIV particle production and ordered capsid assembly. GS-CA1 selects in vitro for unfit GS-CA1-resistant capsid variants that remain fully susceptible to other classes of ARVs. Its high metabolic stability and low solubility enabled sustained drug release in mice following a single subcutaneous dosing. GS-CA1 showed high antiviral efficacy as a long-acting injectable monotherapy in a humanized mouse model of HIV-1 infection, outperforming long-acting rilpivirine. Collectively, these results demonstrate the potential of ultrapotent capsid inhibitors as new long-acting agents for the treatment of HIV-1 infection. A new compound that inhibits HIV capsid assembly and nuclear transport functions offers potential as a long-acting antiretroviral.

Redundancy scheme for a dynamic ram

Abstract: A redundancy scheme for a dynamic memory is arranged to replace defective main memory cells with spare memory cells. The memory array is divided into first and second sectors (L, R), the first sector (L) containing a portion (184) of each main memory column and one or more spare columns (186), and the second sector (R) containing the remaining portion (188) of each main memory column and one or more spare columns (190). Means (192, 194, 196, 198) are provided for accessing the main memory columns and the spare memory columns such that, when a portion (184) of an addressed main column in said first sector (L) is defective and its remaining portion (188) in said second sector (R) is not defective, the non-defective portion (188) of said addressed column is accessed and a spare replacement column (186, 190) in one of said sectors (L, R) is accessed in place of the defective portion of the addressed column. Means (218, 220, 222) are provided for coupling the data associated with the accessed portion of the addressed column and the replacement spare column to a data output (200).

New insight in the preparation of alumina supported hydrotreatment oxidic precursors: A molecular approach

Abstract: The science on the preparation of the hydrodesulfurization oxidic precursors is coming of age, but the chemistry governing their preparation is not yet clearly understood. In this paper, the chemistry of alumina supported oxomolybdate preparation is revisited taking into account the dissolution/precipitation concept recently developed. Classical preparations with the ammonium heptamolybdate and Co nitrate salts will firstly be discussed. Then the use of new starting materials for the preparation of the impregnating solutions will be considered, showing that at high Mo loading the dispersion is strongly dependant on the nature of the starting salts. The use of phosphomolybdate cobalt salts will also be considered. Lastly we will discuss the improvement of the Co promoting effect using molybdocobaltate heteropolyanions as starting materials and complexing agents. This study shows that the maturation step is the determining step for the improvement of preparation of these alumina based oxidic precursor.